Tetrahydroxy stilbene glycoside (TSG) antagonizes Aβ-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway.

[1]  C. Parsons,et al.  Preclinical to phase II amyloid beta (Aβ) peptide modulators under investigation for Alzheimer’s disease , 2017, Expert opinion on investigational drugs.

[2]  Wenhua Zheng,et al.  Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway , 2017, Redox biology.

[3]  Rui Liu,et al.  HO-1 Is Essential for Tetrahydroxystilbene Glucoside Mediated Mitochondrial Biogenesis and Anti-Inflammation Process in LPS-Treated RAW264.7 Macrophages , 2017, Oxidative medicine and cellular longevity.

[4]  Zhuo Yang,et al.  Resveratrol Attenuates Aβ-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels , 2017, Neurotoxicity Research.

[5]  Ru-yi Zhang,et al.  Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP. , 2017, Canadian journal of physiology and pharmacology.

[6]  Qian Yang,et al.  2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress , 2017, Acta Pharmacologica Sinica.

[7]  Marcos Roberto Oliveira,et al.  Pinocembrin Suppresses H2O2-Induced Mitochondrial Dysfunction by a Mechanism Dependent on the Nrf2/HO-1 Axis in SH-SY5Y Cells , 2017, Molecular Neurobiology.

[8]  Qian Yang,et al.  2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Attenuates Ischemia/Reperfusion-Induced Brain Injury in Rats by Promoting Angiogenesis , 2016, Planta Medica.

[9]  Wei Zhang,et al.  2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside exerted protective effects on diabetic nephropathy in mice with hyperglycemia induced by streptozotocin. , 2016, Food & function.

[10]  G. Chao,et al.  Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells , 2016, Neuroscience Letters.

[11]  M. Chiang,et al.  Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction. , 2016, Experimental cell research.

[12]  G. Jeong,et al.  Butein provides neuroprotective and anti‐neuroinflammatory effects through Nrf2/ARE‐dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway , 2016, British journal of pharmacology.

[13]  J. Jeng,et al.  2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside suppresses human colorectal cancer cell metastasis through inhibiting NF-κB activation. , 2016, International journal of oncology.

[14]  M. Won,et al.  Arginase Inhibitor 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function , 2016, Planta Medica.

[15]  K. Anand,et al.  Hippocampal volumes among older Indian adults: Comparison with Alzheimer's disease and mild cognitive impairment , 2016, Annals of Indian Academy of Neurology.

[16]  Zheng Jiang,et al.  Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons , 2016, Neurochemical Research.

[17]  C. Jang,et al.  Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25–35 neurotoxicity , 2015, Neuroscience.

[18]  M. Filip,et al.  Oxidative Stress in Neurodegenerative Diseases , 2015, Molecular Neurobiology.

[19]  P. Proksch,et al.  TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans , 2015, Oxidative medicine and cellular longevity.

[20]  L. Tan,et al.  The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease , 2015, Molecular Neurobiology.

[21]  M. Kim,et al.  Protective effects of Anthocyanins against Amyloid beta-induced neurotoxicity in vivo and in vitro , 2015, Neurochemistry International.

[22]  Ru-yi Zhang,et al.  Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice. , 2015, Restorative neurology and neuroscience.

[23]  Long-chuan Yu,et al.  Potential protection of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons , 2014, Neuroscience Letters.

[24]  Linhong Huang,et al.  Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease. , 2013, Toxicology letters.

[25]  Shiping Ma,et al.  [Peoniflorin activates Nrf2/ARE pathway to alleviate the Abeta(1-42)-induced hippocampal neuron injury in rats]. , 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

[26]  Y. Liu,et al.  Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway , 2013, Free radical research.

[27]  Xiaoping Du,et al.  Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(₁₋₄₂)-injected rats and may be connected to synaptic changes in the hippocampus. , 2012, Canadian journal of physiology and pharmacology.

[28]  S. Chakrabarti,et al.  Aging promotes amyloid-β peptide induced mitochondrial dysfunctions in rat brain: a molecular link between aging and Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[29]  G. McKhann,et al.  Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease , 2008, Nature Medicine.