Cross‐Talk between Aging and Cancer
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[1] J. Issa,et al. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. , 2003, Gastroenterology.
[2] C. Epstein,et al. Werner syndrome: entering the helicase era. , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.
[3] M. Oshimura,et al. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. , 2003, Biochemical and biophysical research communications.
[4] I. Saira Mian,et al. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease , 1998, Nature Genetics.
[5] A. Shimamoto,et al. Impaired nuclear localization of defective DNA helicases in Werner's syndrome , 1997, Nature Genetics.
[6] P. Distefano,et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. , 2005, Journal of medicinal chemistry.
[7] M. McVey,et al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.
[8] L. Aaltonen,et al. Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. , 2001, Cancer research.
[9] G. Schellenberg,et al. Positional Cloning of the Werner's Syndrome Gene , 1996, Science.
[10] G. Martin. Genetic syndromes in man with potential relevance to the pathobiology of aging. , 1978, Birth defects original article series.
[11] Issa Jp. CpG-island methylation in aging and cancer. , 2000 .
[12] F. Dick,et al. The Retinoblastoma Protein Regulates Pericentric Heterochromatin , 2006, Molecular and Cellular Biology.
[13] V. Bohr,et al. Roles of the Werner syndrome protein in pathways required for maintenance of genome stability , 2002, Experimental Gerontology.
[14] V. L. Wilson,et al. DNA methylation decreases in aging but not in immortal cells. , 1983, Science.
[15] S. Wang,et al. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity , 2007, Journal of cellular physiology.
[16] N. Pattabiraman,et al. Hormonal Control of Androgen Receptor Function through SIRT1 , 2006, Molecular and Cellular Biology.
[17] Steven P. Gygi,et al. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase , 2004, Science.
[18] J. Denu,et al. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. , 2003, Molecular cell.
[19] F. Alt,et al. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. , 2006, Genes & development.
[20] T. Jenuwein,et al. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases , 2004, Nature Genetics.
[21] T. Ludwig,et al. Involvement of Human MOF in ATM Function , 2005, Molecular and Cellular Biology.
[22] N. Ellis,et al. Molecular genetics of Bloom's syndrome. , 1996, Human molecular genetics.
[23] C. Bradbury,et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors , 2005, Leukemia.
[24] Kelly M. McGarvey,et al. Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation , 2006, PLoS genetics.
[25] D. Shore,et al. Characterization of two genes required for the position‐effect control of yeast mating‐type genes. , 1984, The EMBO journal.
[26] T. Tollefsbol,et al. Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts , 2003, Molecular and Cellular Biochemistry.
[27] J. Issa,et al. Age-related epigenetic changes and the immune system. , 2003, Clinical immunology.
[28] W. Gu,et al. SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1* , 2005, Journal of Biological Chemistry.
[29] J. Oshima. The Werner syndrome protein: an update , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.
[30] M. Esteller. Relevance of DNA methylation in the management of cancer. , 2003, The Lancet. Oncology.
[31] C. Wolberger,et al. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. , 2005, Molecular cell.
[32] K. McManus,et al. Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development. , 2004, Developmental biology.
[33] M. Oshimura,et al. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress , 2007, Oncogene.
[34] B. Turner,et al. Specific antibodies reveal ordered and cell-cycle-related use of histone-H4 acetylation sites in mammalian cells. , 1989, European journal of biochemistry.
[35] J. Murnane,et al. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. , 1999, Gene.
[36] V. P. Collins,et al. Differential expression of selected histone modifier genes in human solid cancers , 2006, BMC Genomics.
[37] William Arbuthnot Sir Lane,et al. A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16 , 2005, Molecular and Cellular Biology.
[38] M. Mayo,et al. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.
[39] Manel Esteller,et al. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin , 2005, Nature Cell Biology.
[40] L. Donehower,et al. ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse , 2006, Cell cycle.
[41] M. Fraga,et al. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[42] C. Vigouroux,et al. LMNA mutations in atypical Werner's syndrome , 2003, The Lancet.
[43] Florence Hediger,et al. The function of nuclear architecture: a genetic approach. , 2004, Annual review of genetics.
[44] Delin Chen,et al. Negative Control of p53 by Sir2α Promotes Cell Survival under Stress , 2001, Cell.
[45] T. Spector,et al. Epigenetic differences arise during the lifetime of monozygotic twins. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[46] Giacomo Finocchiaro,et al. Lap2α Expression is Controlled by E2F and Deregulated in Various Human Tumors , 2006 .
[47] D. E. Olins,et al. Granulocyte heterochromatin: defining the epigenome , 2005, BMC Cell Biology.
[48] V. Bohr,et al. Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. , 2003, Carcinogenesis.
[49] R. DePinho,et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. , 2006, Cancer research.
[50] Y. Gruenbaum,et al. The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy. , 2006, Journal of structural biology.
[51] Manel Esteller,et al. DNA methylation and cancer therapy: new developments and expectations , 2005, Current opinion in oncology.
[52] S. Horvath,et al. Global histone modification patterns predict risk of prostate cancer recurrence , 2005, Nature.
[53] S. Baylin,et al. Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses , 2005, Cell.
[54] M. Esteller. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future , 2002, Oncogene.
[55] G. Fink,et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration , 2002, Nature.
[56] Markus Schuelke,et al. The spectrum of WRN mutations in Werner syndrome patients , 2006, Human mutation.
[57] O. Kovalchuk,et al. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. , 2005, Carcinogenesis.
[58] J. Broers,et al. Nuclear lamins: laminopathies and their role in premature ageing. , 2006, Physiological reviews.
[59] A. Giordano,et al. RB and cell cycle progression , 2006, Oncogene.
[60] M. Pazin,et al. Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions , 2006, Science.
[61] L. Guarente,et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. , 2001, Cell.
[62] Giacomo Finocchiaro,et al. Lap2alpha expression is controlled by E2F and deregulated in various human tumors. , 2006, Cell cycle.
[63] M. Kuo,et al. Nickel compounds are novel inhibitors of histone H4 acetylation. , 2000, Cancer research.
[64] D. Gottschling,et al. Identification of a small molecule inhibitor of Sir2p , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[65] M. Gray,et al. The Werner syndrome protein is a DNA helicase , 1997, Nature Genetics.
[66] M. Oshimura,et al. Telomere lengths are characteristic in each human individual , 2002, Experimental Gerontology.
[67] R. Weinberg,et al. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase , 2001, Cell.
[68] M. Fraga,et al. Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[69] R. Frye,et al. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. , 1999, Biochemical and biophysical research communications.
[70] L. Guarente,et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.
[71] W. Gu,et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage , 2006, Nature Cell Biology.
[72] L. Guarente,et al. Sir2 links chromatin silencing, metabolism, and aging. , 2000, Genes & development.
[73] Manel Esteller,et al. Towards the Human Cancer Epigenome: A First Draft of Histone Modifications , 2005, Cell cycle.
[74] O. Kovalchuk,et al. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins , 2006, Cancer biology & therapy.
[75] M. Fraga,et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer , 2005, Nature Genetics.
[76] P. Lichter,et al. hMOF Histone Acetyltransferase Is Required for Histone H4 Lysine 16 Acetylation in Mammalian Cells , 2005, Molecular and Cellular Biology.
[77] Delin Chen,et al. Mammalian SIRT1 Represses Forkhead Transcription Factors , 2004, Cell.
[78] D. Sinclair,et al. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1* , 2002, The Journal of Biological Chemistry.
[79] Michael A. Tainsky,et al. Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle , 2003, Molecular and Cellular Biology.
[80] H. Scrable,et al. Progressive loss of SIRT1 with cell cycle withdrawal , 2006, Aging cell.
[81] C. Epstein,et al. A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process , 1966 .
[82] T. Tollefsbol,et al. Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts , 2002, Journal of cellular biochemistry.
[83] Y. Ouchi,et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells , 2006, Oncogene.
[84] J. Issa,et al. CpG-island methylation in aging and cancer. , 2000, Current topics in microbiology and immunology.
[85] C. Plass,et al. Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[86] J. Rine,et al. The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases , 2005, PLoS genetics.
[87] D. Reinberg,et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. , 2004, Molecular cell.
[88] É. Khandjian,et al. Repression of nuclear lamin A and C gene expression in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells. , 1990, Leukemia research.
[89] M. Blasco. Telomeres and human disease: ageing, cancer and beyond , 2005, Nature Reviews Genetics.
[90] A. Shimamoto,et al. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. , 1998, Genomics.
[91] A. Feinberg,et al. Hypomethylation of DNA from benign and malignant human colon neoplasms. , 1985, Science.
[92] B. Sarg,et al. Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging* , 2002, The Journal of Biological Chemistry.
[93] L. Poirier,et al. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. , 2006, Carcinogenesis.
[94] P. Bertolucci,et al. Quantitative evaluation of the rRNA in Alzheimer's disease , 2000, Mechanisms of Ageing and Development.
[95] K. Kasprzak,et al. Inhibition of core histones acetylation by carcinogenic nickel(II) , 2005, Molecular and Cellular Biochemistry.
[96] V. Wilson,et al. Genomic 5-methyldeoxycytidine decreases with age. , 1987, The Journal of biological chemistry.
[97] H. Worman,et al. A-type lamins: Guardians of the soma? , 2004, Nature Cell Biology.
[98] Myriam Gorospe,et al. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase , 2004, Science.
[99] D. Reinberg,et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.