Blood-brain barrier permeation in the rat during exposure to low-power 1.7-GHz microwave radiation.

The permeability of the blood-brain barrier to high-and low-molecular-weight compounds has been measured as a function of continuous-wave (CW) and pulsed-microwave radiation. Adult rats, anesthetized with pentobarbital and injected intravenously with a mixture of [14C] sucrose and [3H] inulin, were exposed for 30 min at a specific absorption rate of 0.1 W/kg to 1.7-GHz CW and pulsed (0.5-microseconds pulse width, 1,000 pps) microwaves. After exposure, the brain was perfused and sectioned into nine regions, and the radioactivity in each region was counted. During identical exposure conditions, temperatures of rats were measured in eight of the brain regions by a thermistor probe that did not perturb the field. No change in uptake of either tracer was found in any of the eight regions as compared with those of sham-exposed animals.

[1]  J. Innes,et al.  Craigie's Neuroanatomy of the rat. , 1963 .

[2]  L. Iversen,et al.  REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I , 1966, Journal of neurochemistry.

[3]  Thomas S. Reese,et al.  FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE , 1967, The Journal of cell biology.

[4]  T. Reese,et al.  JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN , 1969, The Journal of cell biology.

[5]  W H Oldendorf,et al.  Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. , 1970, Brain research.

[6]  A. H. Frey,et al.  NEURAL FUNCTION AND BEHAVIOR: DEFINING THE RELATIONSHIP , 1975, Annals of the New York Academy of Sciences.

[7]  W. Oldendorf,et al.  PEKMEABILITY CHANGES IN THE BLOOD-BRAIN BARRIER: CAUSES AND CONSEQUENCES* , 1975 .

[8]  H. Davson Review lecture. The blood‐brain barrier. , 1976, The Journal of physiology.

[9]  K. J. Oscar,et al.  Microwave alteration of the blood-brain barrier system of rats , 1977, Brain Research.

[10]  J. W. Allis,et al.  Measurement of microwave radiation absorbed by biological systems: 1. Analysis of heating and cooling data , 1977 .

[11]  K. Pettigrew,et al.  Regional cerebrovascular permeability to [14C]sucrose after osmotic opening of the blood-brain barrier , 1978, Brain Research.

[12]  J. H. Merritt,et al.  Studies on blood-brain barrier permeability after microwave-radiation , 1978, Radiation and environmental biophysics.

[13]  J. Viner Introduction by the Editors , 1978 .

[14]  E. Preston,et al.  Permeability of the blood-brain barrier to mannitol in the rat following 2450 MHz microwave irradiation , 1979, Brain Research.

[15]  K. Pettigrew,et al.  A quantitative method for measuring altered cerebrovascular permeability , 1979 .

[16]  Discussion: The blood‐brain barrier, cerebral circulation, and mathematical modeling , 1979 .

[17]  C. Sutton,et al.  Effects of microwave‐induced hyperthermia on the blood‐brain barrier of the rat , 1979 .

[18]  E. Albert Reversibility of microwave‐induced blood‐brain‐barrier permeability , 1979 .

[19]  K.,et al.  Cardiac contractile proteins. Adenosine triphosphatase activity and physiological function. , 1979, Circulation research.

[20]  J. Fleiss,et al.  Some Statistical Methods Useful in Circulation Research , 1980, Circulation research.

[21]  J. C. Lin,et al.  Studies on microwave and blood-brain barrier interaction. , 1980, Bioelectromagnetics.

[22]  C F Starmer,et al.  Clinical Judgment and Statistics: Lessons from a Simulated Randomized Trial in Coronary Artery Disease , 1980, Circulation.

[23]  Y. Isobe,et al.  Diurnal variation of thermal resistance in rats. , 1980, Canadian journal of physiology and pharmacology.

[24]  E. Preston,et al.  Cerebrovascular permeability to sucrose in the rat exposed to 2,450-MHz microwaves. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[25]  E. Albert,et al.  Reversible microwave effects on the blood-brain barrier , 1981, Brain Research.

[26]  S. Rapoport,et al.  Local cerebral blood flow after microwave exposure , 1981, Brain Research.

[27]  W. Joines,et al.  The effect of microwave radiation (1.0 GHz) on the blood‐brain barrier in dogs , 1982 .

[28]  R. Magin,et al.  Microwaves and the Blood-Brain Barrier: A Review , 1982 .

[29]  J. Elder,et al.  Measurement of blood-brain barrier permeation in rats during exposure to 2450-MHz microwaves. , 1982, Bioelectromagnetics.

[30]  J. C. Lin,et al.  Microwave hyperthermia-induced blood-brain barrier alterations. , 1982, Radiation research.

[31]  S. Rapoport,et al.  Absence of microwave effect on blood-brain barrier permeability to [14C]sucrose in the conscious rat , 1982, Experimental Neurology.

[32]  A. H. Frey,et al.  Dopamine Receptors and Microwave Energy Exposure , 1983 .