Effects of Ginseng on Fertility

Ginseng is a representative, traditional Eastern Asian herb used as a tonic for slowing down the aging process. It has become one of the most popular dietary supplements throughout the world. The major active ingredient of ginseng is the ginseng saponin, which is composed of various ginsenosides. Currently, approximately 30 ginsenosides have been identified. Few research studies have attempted to identify the exact effects exerted by each type and constituent of ginseng. Interestingly, the induction of apoptosis of cancer cell lines has been reported in several malignancies, and effects on dopamine release pathways in the brain have been shown. In addition to the traditional medicinal property of ginseng, which has been thought to be a tonic, a few studies have been conducted to identify whether it can improve fertility. However, whether ginseng affects fertility or not remains experimental since most of the studies have been performed in vitro. The aim of this present study was to review relevant studies on the effect of ginseng on male and female reproduction, especially infertility.

[1]  S. Shokri,et al.  Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats , 2017, Andrologia.

[2]  M. Karimfar,et al.  Efficacy of Compound Therapy by Ginseng and Ciprofloxacin on Bacterial Prostatitis , 2016, Cell journal.

[3]  Eryun Zhang,et al.  Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/mTOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mice , 2016, The Journal of Pharmacology and Experimental Therapeutics.

[4]  S. Choe,et al.  Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study , 2016, Chinese Journal of Integrative Medicine.

[5]  C. Yuan,et al.  The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: a randomized, double-blind, placebo-controlled multicenter clinical trial. , 2015, Journal of ethnopharmacology.

[6]  H. Kuang,et al.  American Ginseng Regulates Gene Expression to Protect against Premature Ovarian Failure in Rats , 2015, BioMed research international.

[7]  D. Rahelić,et al.  Ethanol extraction preparation of American ginseng (Panax quinquefolius L) and Korean red ginseng (Panax ginseng C.A. Meyer): differential effects on postprandial insulinemia in healthy individuals. , 2015, Journal of ethnopharmacology.

[8]  H. Kuang,et al.  Preventive Effect of American Ginseng Against Premature Ovarian Failure in a Rat Model , 2014, Drug development research.

[9]  K. Leung,et al.  Ginseng and male reproductive function , 2013, Spermatogenesis.

[10]  I. Khan,et al.  Modulation of ethanol toxicity by Asian ginseng (Panax ginseng) in Japanese ricefish (Oryzias latipes) embryogenesis. , 2013, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[11]  Wen-jie Zhao,et al.  Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats , 2012, Acta Pharmacologica Sinica.

[12]  Min-Ji Bak,et al.  Red Ginseng Marc Oil Inhibits iNOS and COX-2 via NFκB and p38 Pathways in LPS-Stimulated RAW 264.7 Macrophages , 2012, Molecules.

[13]  S. Kim,et al.  Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial , 2012, Menopause.

[14]  S. Nah,et al.  Therapeutic Effect of Korean Red Ginseng Extract on Infertility Caused by Polycystic Ovaries , 2011, Journal of ginseng research.

[15]  L. Xiong,et al.  Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats , 2011, Neurochemistry International.

[16]  Hyung‐Min Kim,et al.  Effects of Panax ginseng on glial cell‐derived neurotrophic factor (GDNF) expression and spermatogenesis in rats , 2011, Phytotherapy research : PTR.

[17]  S. Nam,et al.  Black ginseng inhibits ethanol-induced teratogenesis in cultured mouse embryos through its effects on antioxidant activity. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[18]  E. Ellinwood,et al.  Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens , 2009, Brain Research.

[19]  E. Ernst,et al.  Red ginseng for treating erectile dysfunction: a systematic review. , 2008, British journal of clinical pharmacology.

[20]  Qiu-Ye Lin,et al.  Inhibition of inducible nitric oxide synthase by Acanthopanax senticosus extract in RAW264.7 macrophages. , 2008, Journal of ethnopharmacology.

[21]  Lihui Hou,et al.  [Effects of ginseng total saponins on nerve growth factor expression in rat with estradiol valerate-induced polycystic ovaries]. , 2008, Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.

[22]  S. Nam,et al.  Effects of ginsenosides on organogenesis and expression of glutathione peroxidase genes in cultured rat embryos. , 2008, The Journal of reproduction and development.

[23]  H. Nordeng,et al.  Use of herbal drugs during early pregnancy in relation to maternal characteristics and pregnancy outcome , 2008, Pharmacoepidemiology and drug safety.

[24]  M. Chang,et al.  Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM). , 2007, Fertility and sterility.

[25]  Kee Yoeup Paek,et al.  The therapeutic effect of tissue cultured root of wildPanax ginseng C.A. Mayer on spermatogenetic disorder , 2006, Archives of pharmacal research.

[26]  S. Nah,et al.  Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries. , 2005, Fertility and sterility.

[27]  H. Li,et al.  Effects of several Chinese herbal aqueous extracts on human sperm motility in vitro , 2004, Andrologia.

[28]  Dong-Hyun Kim,et al.  Transformation of ginseng saponins to ginsenoside rh2 by acids and human intestinal bacteria and biological activities of their transformants , 2004, Archives of pharmacal research.

[29]  H. Suh,et al.  The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice , 2003, Neuroscience Letters.

[30]  J. Lindstrom,et al.  In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins. , 2003, Biochemical pharmacology.

[31]  Deok-Chun Yang,et al.  Modulating effects of Korean ginseng saponins on ovarian function in immature rats. , 2003, Biological & pharmaceutical bulletin.

[32]  J. Hong,et al.  A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. , 2002, The Journal of urology.

[33]  L. Murphy,et al.  Ginseng, Sex Behavior, and Nitric Oxide , 2002, Annals of the New York Academy of Sciences.

[34]  I. Wiklund,et al.  Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group. , 1999, International journal of clinical pharmacology research.

[35]  C. Yuan,et al.  Modulation of American ginseng on brainstem GABAergic effects in rats. , 1998, Journal of ethnopharmacology.

[36]  L. Marcellini,et al.  Effects of Panax Ginseng C.A. Meyer saponins on male fertility. , 1996, Panminerva medica.

[37]  Xiu Chen,et al.  Ginsenosides‐induced nitric oxide‐mediated relaxation of the rabbit corpus cavernosum , 1995, British journal of pharmacology.

[38]  Y. Zheng,et al.  [Ginseng saponin treatment for intrauterine growth retardation]. , 1994, Zhonghua yi xue za zhi.

[39]  K. Oh,et al.  Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. , 1994, General pharmacology.

[40]  C. Benishin Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings , 1992, Neurochemistry International.

[41]  G. Koren,et al.  Maternal ginseng use associated with neonatal androgenization. , 1990, JAMA.

[42]  B. Rim Ultrastructural studies on the effects of Korean Panax ginseng on the theca interna of rat ovary. , 1979, The American journal of Chinese medicine.