Mesolimbic Dopamine Reward System Hypersensitivity in Individuals with Psychopathic Traits

Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [18F]fallypride positron emission tomography and blood oxygen level–dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy.

[1]  G. Walters.  Predicting Institutional Adjustment and Recidivism with the Psychopathy Checklist Factor Scores: A Meta-Analysis , 2003, Law and human behavior.

[2]  R. Blair,et al.  The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[3]  David A. Anderson,et al.  The Aggregate Burden of Crime , 1999 .

[4]  H. Heinze,et al.  Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release , 2008, The Journal of Neuroscience.

[5]  R. Mailman,et al.  Social Reactivity and D1 Dopamine Receptors: Studies in Mice Selectively Bred for High and Low Levels of Aggression , 1994, Neuropsychopharmacology.

[6]  C. Patrick,et al.  A prospective comparison of two measures of psychopathy in the prediction of institutional misconduct. , 2008, Behavioral sciences & the law.

[7]  T. Robbins,et al.  Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[8]  C. Kennedy,et al.  The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice , 2008, Psychopharmacology.

[9]  R. Rodriguiz,et al.  Aberrant responses in social interaction of dopamine transporter knockout mice , 2004, Behavioural Brain Research.

[10]  Jennifer L. Skeem,et al.  Psychopathy and community violence among civil psychiatric patients: results from the MacArthur Violence Risk Assessment Study. , 2001, Journal of consulting and clinical psychology.

[11]  B. Pitt.  Psychopharmacology , 1968, Mental Health.

[12]  K. Miczek,et al.  ß Federation of European Neuroscience Societies Accumbal dopamine and serotonin in anticipation of the next aggressive episode in rats , 2022 .

[13]  R. Hare,et al.  Psychopathic traits in a large community sample: links to violence, alcohol use, and intelligence. , 2008, Journal of consulting and clinical psychology.

[14]  R. Hare.  Psychopathy: a clinical and forensic overview. , 2006, The Psychiatric clinics of North America.

[15]  Alcohol and drug abuse-dependence disorders in psychopathic and nonpsychopathic criminal offenders. , 1990 .

[16]  Christopher J Patrick,et al.  Factor structure of the psychopathic personality inventory: validity and implications for clinical assessment. , 2003, Psychological assessment.