Avascular Necrosis of Head of Femur in a Patient with Acute Promyelocytic Leukemia

Avascular necrosis (AVN) of head of the femur is associated with various pathological conditions and treatment modalities. We present a case of acute promyelocytic leukemia who was treated with all-transretinoic acid (ATRA), daunomycin, cytarabine and a short course of dex-amethasone. He developed AVN of bone after 2 years of treatment. Whether this is related to ATRA is dealt with in the discussion.

[1]  P. Wiernik,et al.  Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L‐asparaginase, and dexamethasone (MOAD) , 1996, American journal of hematology.

[2]  Freeman Hj,et al.  Non-Corticosteroid-Associated Osteonecrosis of the Femoral Heads in Two Patients with Inflammatory Bowel Disease , 1993 .

[3]  J. Arlet,et al.  Nontraumatic avascular necrosis of the femoral head. Past, present, and future. , 1992, Clinical orthopaedics and related research.

[4]  G. Bentley,et al.  The role of computerised tomography in intervertebral disc prolapse. , 1986, The Journal of bone and joint surgery. British volume.

[5]  J. D. Spencer,et al.  Early avascular necrosis of the femoral head. Report of a case and review of the literature. , 1986, The Journal of bone and joint surgery. British volume.

[6]  S. Advani,et al.  Avascular necrosis following combination chemotherapy. , 1985, Indian Journal of Cancer.

[7]  V. Devita,et al.  Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids) , 1975, Cancer.

[8]  S. Pai,et al.  Avascular necrosis of bone--a complication of aggressive therapy for acute lymphoblastic leukemia. , 1998, Acta oncologica.

[9]  C. Pui,et al.  Avascular femoral head necrosis in pediatric cancer patients. , 1993, Medical and pediatric oncology.

[10]  S. Pai,et al.  Avascular Necrosis of Bone in Acute Lymphoblastic Leukemia , 1987, The American journal of pediatric hematology/oncology.