Impact of Partial Volume Correction on Kinetic Parameters: Preliminary Experience in Patient Studies

Two radioligands specific for the dopamine system were used to study the influence of correction for partial volume effects on quantitative binding data obtained from positron emission tomography from various brain regions. [11C]Raclopride binds to the dopamine D2 and D3 receptors, and [11C]WIN 35,428 binds to the dopamine transporter. Both are highly concentrated in the basal ganglia but not in the cerebellum. Normal subjects and patients with Lesch-Nyhan syndrome, a disease in which brain atrophy occurs, were studied before and after correction for the partial volume effect. A dramatic elevation in rate constants, especially the k3/k4 ratio, was observed after correction in both normal subjects and patients. The patients, who initially had a decrease in [11C]WIN 35,428 binding at the dopamine transporter site compared to normal subjects, retained this separation after the correction algorithm was applied.

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