Complex Dynamics of an SIR Epidemic Model with Saturated Incidence Rate and Treatment

This paper describes a traditional SIR type epidemic model with saturated infection rate and treatment function. The dynamics of the model is studied from the point of view of stability and bifurcation. Basic reproduction number is obtained and it is shown that the model system may possess a backward bifurcation. The global asymptotic stability of the endemic equilibrium is studied with the help of a geometric approach. Optimal control problem is formulated and solved. Some numerical simulation works are carried out to validate our analytical results.

[1]  Wendi Wang Backward bifurcation of an epidemic model with treatment. , 2006, Mathematical biosciences.

[2]  G. Serio,et al.  A generalization of the Kermack-McKendrick deterministic epidemic model☆ , 1978 .

[3]  Khalid Hattaf,et al.  Optimal Control of a Delayed SIRS Epidemic Model with Vaccination and Treatment , 2015, Acta biotheoretica.

[4]  Soovoojeet Jana,et al.  Application of three controls optimally in a vector-borne disease - a mathematical study , 2013, Commun. Nonlinear Sci. Numer. Simul..

[5]  S. C. Mpeshe,et al.  Optimal Control and Sensitivity Analysis of an Influenza Model with Treatment and Vaccination , 2011, Acta biotheoretica.

[6]  N. G. Parke,et al.  Ordinary Differential Equations. , 1958 .

[7]  J. Watmough,et al.  Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. , 2002, Mathematical biosciences.

[8]  Zhilan Feng,et al.  Homoclinic Bifurcation in an SIQR Model for Childhood Diseases , 2000 .

[9]  Oluwole Daniel Makinde,et al.  Adomian decomposition approach to a SIR epidemic model with constant vaccination strategy , 2007, Appl. Math. Comput..

[10]  James S. Muldowney,et al.  A Geometric Approach to Global-Stability Problems , 1996 .

[11]  Deborah Lacitignola,et al.  On the backward bifurcation of a vaccination model with nonlinear incidence , 2011 .

[12]  Xianning Liu,et al.  Backward bifurcation of an epidemic model with saturated treatment function , 2008 .

[13]  Soovoojeet Jana,et al.  Complex dynamics of an epidemic model with vaccination and treatment controls , 2016 .

[14]  Zhipeng Qiu,et al.  Transmission Dynamics of an Influenza Model with Vaccination and Antiviral Treatment , 2010, Bulletin of mathematical biology.

[15]  W. O. Kermack,et al.  A contribution to the mathematical theory of epidemics , 1927 .

[16]  Zhen Jin,et al.  Bifurcation analysis of a delayed epidemic model , 2010, Appl. Math. Comput..

[17]  Joydip Dhar,et al.  Analysis of an SVEIS epidemic model with partial temporary immunity and saturation incidence rate , 2012 .

[18]  Zhenqing Li,et al.  Complex dynamics of a reaction–diffusion epidemic model , 2012 .

[19]  Bilal Ilyas,et al.  TRAVELING WAVES FOR A SIMPLE DIFFUSIVE EPIDEMIC MODEL , 1995 .

[20]  H. Thieme,et al.  Recurrent outbreaks of childhood diseases revisited: the impact of isolation. , 1995, Mathematical biosciences.

[21]  Shigui Ruan,et al.  Analysis of SIR epidemic models with nonlinear incidence rate and treatment. , 2012, Mathematical biosciences.

[22]  Kai Zhou,et al.  Optimal Vaccination Policies for an SIR Model with Limited Resources , 2014, Acta biotheoretica.

[23]  Julien Arino,et al.  An epidemiology model that includes a leaky vaccine with a general waning function , 2004 .

[24]  L. S. Pontryagin,et al.  Mathematical Theory of Optimal Processes , 1962 .

[25]  Meng Fan,et al.  Dynamics of an SIR epidemic model with limited medical resources revisited , 2012 .

[26]  Robert H. Martin Logarithmic norms and projections applied to linear differential systems , 1974 .

[27]  Seyed M. Moghadas,et al.  A qualitative study of a vaccination model with non-linear incidence , 2003, Appl. Math. Comput..

[28]  Soovoojeet Jana,et al.  A mathematical study of a prey–predator model in relevance to pest control , 2013 .

[29]  Kazeem O. Okosun,et al.  Optimal control analysis of a malaria disease transmission model that includes treatment and vaccination with waning immunity , 2011, Biosyst..

[30]  W. Eckalbar,et al.  Dynamics of an epidemic model with quadratic treatment , 2011 .

[31]  Soovoojeet Jana,et al.  A theoretical study on mathematical modelling of an infectious disease with application of optimal control , 2013, Biosyst..

[32]  Maia Martcheva,et al.  SEROTYPE REPLACEMENT OF VERTICALLY TRANSMITTED DISEASES THROUGH PERFECT VACCINATION , 2008 .

[33]  Jia Li,et al.  Modeling the Effectiveness of Isolation Strategies in Preventing STD Epidemics , 1998, SIAM J. Appl. Math..

[34]  Deborah Lacitignola,et al.  Global stability of an SIR epidemic model with information dependent vaccination. , 2008, Mathematical biosciences.