Therapeutic Application of Musically Modulated Electromagnetic Fields in the Treatment of Musculoskeletal Disorders

Different studies have demonstrated the efficacy of extremely low frequency electromagnetic fields (ELF EMFs) in the treatment of pain. In particular, the positive effects of ELF EMFs seems to depend on their respective codes, such as frequency, intensity and waveform, even if the exact mechanism of interaction is still debated. The most commonly used for extremely low frequency magnetotherapy is a 100Hz sinusoidal field (ELF) with a mean of induction of few Gauss. This article reviews the therapeutic application of a musically modulated electromagnetic field (TAMMEF), a new-generation of electromagnetic field used for extremely low frequency magnetotherapy characterized by variable frequencies, intensities and waveforms. Both clinical and experimental studies, performed by authors of the present review, have demonstrated the efficacy of ELF and the new TAMMEF systems in several musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, carpal tunnel syndrome, shoulder periarthritis and cervical spondylosis. Moreover, it has been demonstrated that ELF and TAMMEF systems are not only effective, but also safe, from clinical and experimental point of view. In fact, clinical trials did not reported any undesired side effect, while in vitro studies showed that ELF EMFs did not induce uncontrolled cell proliferation, did not affect cell viability and did not induce apoptosis. With their efficacy and safety, ELF and even more the new TAMMEF systems represent a valid complementary or alternative treatment to standard pharmacological therapies in reducing both pain and inflammation of patients affected by musculoskeletal disorders.

[1]  D. Haverkamp,et al.  Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee , 2012, BioDrugs.

[2]  D. Casper,et al.  Attenuation of interleukin-1beta by pulsed electromagnetic fields after traumatic brain injury , 2012, Neuroscience Letters.

[3]  A. Fioravanti,et al.  In vitro exposure of human osteoarthritic chondrocytes to ELF fields and new therapeutic application of musically modulated electromagnetic fields: biological evidence. , 2012, Journal of biological regulators and homeostatic agents.

[4]  F. Blanco,et al.  The role of mitochondria in osteoarthritis , 2011, Nature Reviews Rheumatology.

[5]  C. Ganellin Personal reflections on Sir James Black (1924–2010) and histamine , 2010, Inflammation Research.

[6]  Kim Henriksen,et al.  Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis? , 2010, Rheumatology International.

[7]  A. Albanese,et al.  Alterations in Adenylate Kinase Activity in Human PBMCs after In Vitro Exposure to Electromagnetic Field: Comparison between Extremely Low Frequency Electromagnetic Field (ELF) and Therapeutic Application of a Musically Modulated Electromagnetic Field (TAMMEF) , 2009, Journal of biomedicine & biotechnology.

[8]  Jianguo Song,et al.  Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition. , 2009, Cancer research.

[9]  R. Iwakiri [NSAIDs and its gastrointestinal side effects: relation of NSAIDs variety and influence of concomitant medicine]. , 2007, Nihon rinsho. Japanese journal of clinical medicine.

[10]  Xiaojun Zhang,et al.  Effects of Different Extremely Low-Frequency Electromagnetic Fields on Osteoblasts , 2007, Electromagnetic biology and medicine.

[11]  F. Blanco,et al.  Mitochondrial proteomic characterization of human normal articular chondrocytes. , 2006, Osteoarthritis and cartilage.

[12]  R. Loeser Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. , 2006, Arthritis and rheumatism.

[13]  G. Verbruggen Chondroprotective drugs in degenerative joint diseases. , 2006, Rheumatology.

[14]  R. Dubner Peripheral and central mechanisms of pain , 2006, AGE.

[15]  A. Fioravanti,et al.  Effect of continuous high hydrostatic pressure on the morphology and cytoskeleton of normal and osteoarthritic human chondrocytes cultivated in alginate gels. , 2005, Clinical and experimental rheumatology.

[16]  A. Boninsegna,et al.  50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism. , 2005, Biochimica et biophysica acta.

[17]  B. Gregori,et al.  Neurophysiological classification of carpal tunnel syndrome: assessment of 600 symptomatic hands , 1997, The Italian Journal of Neurological Sciences.

[18]  É. Molnár,et al.  Therapy with pulsed electromagnetic fields in aseptic loosening of total hip protheses: A prospective study , 1996, Clinical Rheumatology.

[19]  A. Scribano,et al.  Efficacy and safety of a musically modulated electromagnetic field (TAMMEF) in patients affected by knee osteoarthritis. , 2004, Clinical and experimental rheumatology.

[20]  S. N. Young,et al.  Effects of Electromagnetic Fields on the Levels of Biogenic Amine Metabolites, Quinolinic Acid, and β-Endorphin in the Cerebrospinal Fluid of Dairy Cows , 1998, Neurochemical Research.

[21]  P. Richette,et al.  Structure-modifying agents for osteoarthritis: an update. , 2004, Joint, bone, spine : revue du rhumatisme.

[22]  P. Volpe Interactions of zero-frequency and oscillating magnetic fields with biostructures and biosystems , 2003, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[23]  P. Bellavite,et al.  Biological Effects of Electromagnetic Fields , 2002 .

[24]  E. Battisti,et al.  Comparison between the analgesic and therapeutic effects of a musically modulated electromagnetic field (TAMMEF) and those of a 100 Hz electromagnetic field: blind experiment on patients suffering from cervical spondylosis or shoulder periarthritis , 2002, Journal of medical engineering & technology.

[25]  J. Jacobson,et al.  Low-amplitude, extremely low frequency magnetic fields for the treatment of osteoarthritic knees: a double-blind clinical study. , 2001, Alternative therapies in health and medicine.

[26]  Nicola Giordano,et al.  Effect of Electromagnetic Fields on Bone Mineral Density and Biochemical Markers of Bone Turnover in Osteoporosis: A Single-Blind, Randomized Pilot Study , 2001 .

[27]  D. Woolley,et al.  Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. , 2001, Arthritis and rheumatism.

[28]  B. Lucani,et al.  Analgesic-antiinflammatory effect of a 100 Hz variable magnetic field in RA. , 2000, Clinical and experimental rheumatology.

[29]  D. Trock Electromagnetic fields and magnets. Investigational treatment for musculoskeletal disorders. , 2000, Rheumatic diseases clinics of North America.

[30]  V. Fialka-Moser,et al.  [Clinical effectiveness of magnetic field therapy--a review of the literature]. , 2000, Acta medica Austriaca.

[31]  M. Schäfer [Physiology and pathophysiology of pain]. , 1999, Therapeutische Umschau. Revue therapeutique.

[32]  H. Berg,et al.  Problems of weak electromagnetic field effects in cell biology. , 1999, Bioelectrochemistry and bioenergetics.

[33]  Bonnie F. Sloane,et al.  Intracellular accumulation of the amyloidogenic L68Q variant of human cystatin C in NIH/3T3 cells. , 1998, Molecular pathology : MP.

[34]  J. Walleczek,et al.  Magnetic field perturbations as a tool for controlling enzyme-regulated and oscillatory biochemical reactions. , 1998, Biophysical chemistry.

[35]  A. Parola,et al.  Effect of sinusoidally varying magnetic fields on cell proliferation and adenosine deaminase specific activity. , 1998, Bioelectromagnetics.

[36]  J. Shelhamer,et al.  p11, a Unique Member of the S100 Family of Calcium-binding Proteins, Interacts with and Inhibits the Activity of the 85-kDa Cytosolic Phospholipase A2 * , 1997, The Journal of Biological Chemistry.

[37]  H. Madsen,et al.  Influence of magnetic field on the precipitation of some inorganic salts , 1995 .

[38]  Nigel Paneth,et al.  Neurobehavioral effects of power-frequency electromagnetic fields , 1993 .

[39]  N. Paneth,et al.  Neurobehavioral effects of power-frequency electromagnetic fields. , 1993, Environmental health perspectives.

[40]  M. Grandolfo Extremely low frequency electromagnetic fields: Environmental exposure levels, epidemiological studies and risk assessment , 1993 .

[41]  J. Walleczek,et al.  Electromagnetic field effects on cells of the immune system: the role of calcium signaling 1 , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[42]  W. R. Adey,et al.  The effects of low-energy 60-Hz environmental electromagnetic fields upon the growth-related enzyme ornithine decarboxylase. , 1987, Carcinogenesis.

[43]  H. Mankin,et al.  Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules. , 1981, The Journal of bone and joint surgery. American volume.

[44]  B. Lipinski Biological significance of piezoelectricity in relation to acupuncture, Hatha Yoga, osteopathic medicine and action of air ions. , 1977, Medical hypotheses.

[45]  E. C. Huskisson,et al.  Graphic representation of pain , 1976, Pain.

[46]  R. J. Pawluk,et al.  ACCELERATION OF FRACTURE REPAIR BY ELECTROMAGNETIC FIELDS. A SURGICALLY NONINVASIVE METHOD , 1974, Annals of the New York Academy of Sciences.