Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

[1]  M. Rogers,et al.  Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice , 2018, Molecular Neurobiology.

[2]  M. Chao,et al.  p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis , 2018, Journal of neurochemistry.

[3]  D. Stokes,et al.  The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor , 2017, The Journal of Biological Chemistry.

[4]  S. Limborska,et al.  Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere , 2016, Molecular Biology.

[5]  A. Pitkänen,et al.  Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets , 2016, Scientific Reports.

[6]  Adam R Ferguson,et al.  A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury , 2016, Brain : a journal of neurology.

[7]  J. Alder,et al.  Genetic and pharmacological intervention of the p75NTR pathway alters morphological and behavioural recovery following traumatic brain injury in mice , 2016, Brain injury.

[8]  C. Ibáñez,et al.  Structural basis of death domain signaling in the p75 neurotrophin receptor , 2015, eLife.

[9]  YingChun Liu,et al.  All-trans-retinoic Acid Reduces BACE1 Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling* , 2015, The Journal of Biological Chemistry.

[10]  Kimberly S. Williams,et al.  The p75 neurotrophin receptor: at the crossroad of neural repair and death , 2015, Neural regeneration research.

[11]  H. Scharfman,et al.  p75NTR, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice , 2014, ASN neuro.

[12]  C. Iadecola,et al.  MiR-592 Regulates the Induction and Cell Death-Promoting Activity of p75NTR in Neuronal Ischemic Injury , 2014, The Journal of Neuroscience.

[13]  G. Gibney,et al.  p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells* , 2014, The Journal of Biological Chemistry.

[14]  L. McMahon,et al.  Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. , 2013, Journal of Alzheimer's disease : JAD.

[15]  R. Yan,et al.  BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway. , 2013, Cell reports.

[16]  D. Nicholson,et al.  The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques , 2013, Acta Neuropathologica.

[17]  Jing Jing Li,et al.  Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons. , 2013, Cell metabolism.

[18]  E. Eckman,et al.  Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes* , 2013, The Journal of Biological Chemistry.

[19]  B. de Strooper,et al.  The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. , 2012, The Journal of Biological Chemistry.

[20]  Sean M. Riordan,et al.  β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects*♦ , 2012, The Journal of Biological Chemistry.

[21]  Yong Shen,et al.  Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1 , 2012, The Journal of Neuroscience.

[22]  Carlos F. Ibáñez,et al.  p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity , 2012, Trends in Neurosciences.

[23]  C. Atkins,et al.  STAT3 signaling after traumatic brain injury , 2012, Journal of neurochemistry.

[24]  Y. Tone,et al.  Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. , 2012, The international journal of neuropsychopharmacology.

[25]  T. Bozza,et al.  The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb , 2011, Molecular Neurodegeneration.

[26]  C. Hang,et al.  Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats , 2011, Neuroscience Letters.

[27]  Doo Yeon Kim,et al.  Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit , 2010, Molecular Neurodegeneration.

[28]  Douglas H. Smith,et al.  Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? , 2010, Nature Reviews Neuroscience.

[29]  Z. Korade,et al.  p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17* , 2010, The Journal of Biological Chemistry.

[30]  P. Mathews,et al.  Age‐dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model , 2009, Journal of neurochemistry.

[31]  N. Berman,et al.  Impaired expression of neuroprotective molecules in the HIF-1alpha pathway following traumatic brain injury in aged mice. , 2009, Journal of neurotrauma.

[32]  W. Friedman,et al.  Inflammatory cytokines IL-1β and TNF-α regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms , 2009, ASN neuro.

[33]  P. Bastiaens,et al.  Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers , 2009, Neuron.

[34]  Y. Matsuoka,et al.  Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury , 2009, Nature Medicine.

[35]  B. Trapp,et al.  Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  D. Price,et al.  Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice , 2008, Proceedings of the National Academy of Sciences.

[37]  D. Graham,et al.  Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans , 2007, Experimental Neurology.

[38]  R. Vassar,et al.  The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer’s Disease , 2007, Current genomics.

[39]  V. Lee,et al.  BACE1 regulates voltage-gated sodium channels and neuronal activity , 2007, Nature Cell Biology.

[40]  R. Berry,et al.  β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis , 2007, The Journal of Neuroscience.

[41]  P. Saftig,et al.  Control of Peripheral Nerve Myelination by the ß-Secretase BACE1 , 2006, Science.

[42]  L. Reichardt,et al.  Neurotrophin-regulated signalling pathways , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[43]  M. Sastre,et al.  Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease , 2006, Progress in Neurobiology.

[44]  H. Cai,et al.  BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions , 2005, The Journal of Neuroscience.

[45]  Petti T. Pang,et al.  The yin and yang of neurotrophin action , 2005, Nature Reviews Neuroscience.

[46]  W. Gan,et al.  ATP mediates rapid microglial response to local brain injury in vivo , 2005, Nature Neuroscience.

[47]  M. Chao,et al.  Cleavage of p75 Neurotrophin Receptor by α-Secretase and γ-Secretase Requires Specific Receptor Domains* , 2005, Journal of Biological Chemistry.

[48]  Wanpin Chang,et al.  GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)* , 2005, Journal of Biological Chemistry.

[49]  F. Miller,et al.  Activity Regulates Positive and Negative Neurotrophin-Derived Signals to Determine Axon Competition , 2005, Neuron.

[50]  H. Qing,et al.  Oxidative stress potentiates BACE1 gene expression and Aβ generation , 2005, Journal of Neural Transmission.

[51]  J. Simpkins,et al.  Increased β-secretase activity and expression in rats following transient cerebral ischemia , 2004, Brain Research.

[52]  Barbara L. Hempstead,et al.  Sortilin is essential for proNGF-induced neuronal cell death , 2004, Nature.

[53]  G. Weskamp,et al.  Evidence for a Critical Role of the Tumor Necrosis Factor α Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75NTR)* , 2004, Journal of Biological Chemistry.

[54]  G. Ransmayr,et al.  Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer’s disease β-secretase (BACE-1) , 2004, Journal of Neural Transmission.

[55]  J. Dickenson,et al.  Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death. , 2004, European journal of pharmacology.

[56]  F. Gaunitz,et al.  Cloning and expression of the rat BACE1 promoter , 2003, Journal of neuroscience research.

[57]  T. Jovin,et al.  Ligand-Induced Internalization of the p75 Neurotrophin Receptor: A Slow Route to the Signaling Endosome , 2003, The Journal of Neuroscience.

[58]  T. Kilpatrick,et al.  Schwann Cell Apoptosis in the Postnatal Axotomized Sciatic Nerve Is Mediated Via NGF through the Low‐Affinity Neurotrophin Receptor , 2003, Journal of neuropathology and experimental neurology.

[59]  V. Bigl,et al.  Astrocytic expression of the Alzheimer's disease β‐secretase (BACE1) is stimulus‐dependent , 2003, Glia.

[60]  N. Kasthuri,et al.  Long-term dendritic spine stability in the adult cortex , 2002, Nature.

[61]  R. Segal,et al.  p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp , 2002, Nature.

[62]  Y. Barde,et al.  The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system , 2002, Nature Neuroscience.

[63]  J. Kim,et al.  ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury , 2002, Neuron.

[64]  B. Hyman,et al.  Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. , 2002, Archives of neurology.

[65]  G. Perry,et al.  Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons , 2002, Neurobiology of Disease.

[66]  B. Hempstead.  The many faces of p75NTR , 2002, Current Opinion in Neurobiology.

[67]  L. Acarín,et al.  NF‐κB and IκBα expression following traumatic brain injury to the immature rat brain , 2002, Journal of neuroscience research.

[68]  J. Kim,et al.  Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis , 2002, The Journal of Neuroscience.

[69]  V. Bigl,et al.  Neuronal and glial β‐secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology , 2001, Journal of neuroscience research.

[70]  F. Lee,et al.  The uniqueness of being a neurotrophin receptor , 2001, Current Opinion in Neurobiology.

[71]  M. Meyer,et al.  Endogenous Brain-Derived Neurotrophic Factor and Neurotrophin-3 Antagonistically Regulate Survival of Axotomized Corticospinal Neurons In Vivo , 2001, The Journal of Neuroscience.

[72]  H. Cai,et al.  BACE1 is the major β-secretase for generation of Aβ peptides by neurons , 2001, Nature Neuroscience.

[73]  Kuo-Fen Lee,et al.  p75 Is Important for Axon Growth and Schwann Cell Migration during Development , 2000, The Journal of Neuroscience.

[74]  B. Strooper,et al.  Proteolytic processing and cell biological functions of the amyloid precursor protein. , 2000, Journal of cell science.

[75]  L. Butcher,et al.  Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain , 2000, Brain Research.

[76]  R. Barbour,et al.  Purification and cloning of amyloid precursor protein β-secretase from human brain , 1999, Nature.

[77]  P. Casaccia‐Bonnefil,et al.  Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques , 1999, Neurology.

[78]  J. Treanor,et al.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.

[79]  Philippe P Roux,et al.  p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure , 1999, The Journal of Neuroscience.

[80]  F. Miller,et al.  Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation , 1999, The Journal of Neuroscience.

[81]  A. Davies,et al.  p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor , 1999, Molecular and Cellular Neuroscience.

[82]  Y. Barde,et al.  Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR , 1999, The EMBO journal.

[83]  O. Lindvall,et al.  Focal cerebral ischemia in rats induces expression of p75 neurotrophin receptor in resistant striatal cholinergic neurons , 1998, Neuroscience.

[84]  D. Hinkle,et al.  GFAP and S100beta expression in the cortex and hippocampus in response to mild cortical contusion. , 1997, Journal of neurotrauma.

[85]  G. Otting,et al.  NMR structure of the death domain of the p75 neurotrophin receptor , 1997, The EMBO journal.

[86]  R. Rush,et al.  Differential Expression of the p75 Nerve Growth Factor Receptor in Glia and Neurons of the Rat Dorsal Root Ganglia after Peripheral Nerve Transection , 1996, The Journal of Neuroscience.

[87]  L. Murray,et al.  Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[88]  L. Butcher,et al.  Induction of apoptosis by the low-affinity NGF receptor. , 1993, Science.

[89]  M. Nieto‐Sampedro,et al.  Lesion-induced expression of low-affinity nerve growth factor receptor-immunoreactive protein in Purkinje cells of the adult rat , 1993, Neuroscience.

[90]  R. Jaenisch,et al.  Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system , 1992, Cell.

[91]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[92]  T. Crawford,et al.  Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons , 1991, Brain Research.

[93]  D. Kaplan,et al.  High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor , 1991, Nature.

[94]  D. Selkoe.  The molecular pathology of Alzheimer's disease , 1991, Neuron.

[95]  R. Loy,et al.  Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[96]  L. Olson,et al.  Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons , 1989, Neuron.

[97]  H. Clark,et al.  Induction of nerve growth factor receptor in Schwann cells after axotomy. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[98]  A. Ross,et al.  Gene transfer and molecular cloning of the human NGF receptor. , 1986, Science.

[99]  J. Treanor,et al.  Title beta-secretase cleavage of Alzheimer ' s amyloid precursor protein by the transmembrane aspartic protease , 2015 .

[100]  Jun Wu,et al.  Luteolin Reduces BACE1 Expression through NF-κB and through Estrogen Receptor Mediated Pathways in HEK293 and SH-SY5Y Cells. , 2015, Journal of Alzheimer's disease : JAD.

[101]  B. Hempstead.  Deciphering proneurotrophin actions. , 2014, Handbook of experimental pharmacology.

[102]  M. Tabaton,et al.  Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway. , 2011, Journal of Alzheimer's disease : JAD.

[103]  E. Coulson,et al.  The p75 neurotrophin receptor. , 2008, The international journal of biochemistry & cell biology.

[104]  M. Chao,et al.  Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. , 2005, The Journal of biological chemistry.

[105]  P. Wong,et al.  Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease , 2003, Nature Medicine.

[106]  M. Chao,et al.  Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. , 1995, Developmental biology.

[107]  M. Tohyama,et al.  Effects of nerve crush and transection on mRNA levels for nerve growth factor receptor in the rat facial motoneurons. , 1991, Brain research. Molecular brain research.