Pupillometric Study of the Dysregulation of the Autonomous Nervous System by SVM Networks

Pupil is controlled by the autonomous nervous system. Patients with temporomandibular disorders (TMD) and with obstructive sleep apnea syndrome (OSAS) are affected by a dysregulation of the autonomous system. Pupillometry is here used to investigate the state of the autonomous system in 3 groups: control, TMD and OSAS. Different indexes are extracted from the pupillogram to characterize pupil dynamics investigated in rest and under stationary stimulations. All possible sets of 3 and 4 indexes are used as features to train support vector machines (SVM) to identify the correct groups. The indexes providing optimal classification are identified.

[1]  M. Villa,et al.  Autonomic cardiovascular tests in children with obstructive sleep apnea syndrome. , 2010, Sleep.

[2]  Giovanni Calcagnini,et al.  Coupling patterns between spontaneous rhythms and respiration in cardiovascular variability signals , 2002, Comput. Methods Programs Biomed..

[3]  P. Quartana,et al.  Nocturnal heart rate variability is lower in temporomandibular disorder patients than in healthy, pain-free individuals. , 2011, Journal of orofacial pain.

[4]  Corinna Cortes,et al.  Support-Vector Networks , 1995, Machine Learning.

[5]  H. Lüdtke,et al.  Daytime variations in central nervous system activation measured by a pupillographic sleepiness test , 2001, Journal of sleep research.

[6]  B. Wallin,et al.  Daytime sympathetic hyperactivity in OSAS is related to excessive daytime sleepiness , 2007, Journal of sleep research.

[7]  L. Mesin,et al.  Investigation of Nonlinear Pupil Dynamics by Recurrence Quantification Analysis , 2013, BioMed research international.

[8]  D. Eckberg Sympathovagal balance: a critical appraisal. , 1997, Circulation.

[9]  M. Javorka,et al.  The effect of orthostasis on recurrence quantification analysis of heart rate and blood pressure dynamics , 2009, Physiological measurement.

[10]  Andreas Voss,et al.  Correlations between the autonomic modulation of heart rate, blood pressure and the pupillary light reflex in healthy subjects , 2009, Journal of the Neurological Sciences.

[11]  Jürgen Kurths,et al.  Recurrence plots for the analysis of complex systems , 2009 .

[12]  W. Pickworth,et al.  Pupillometry in the detection of concomitant drug use in opioid-maintained patients. , 2004, Methods and findings in experimental and clinical pharmacology.

[13]  A. Karlovasitou,et al.  Evaluation of autonomic imbalance in patients with heart failure: a preliminary study of pupillomotor function. , 2010, Cardiology journal.

[14]  L. Cao Practical method for determining the minimum embedding dimension of a scalar time series , 1997 .

[15]  W. Maixner,et al.  Genetic basis for individual variations in pain perception and the development of a chronic pain condition. , 2005, Human molecular genetics.

[16]  P. Borgdorff,et al.  Respiratory fluctuations in pupil size. , 1975, The American journal of physiology.

[17]  Patrick Y Lee,et al.  Autonomic dysregulation as a basis of cardiovascular, endocrine, and inflammatory disturbances associated with obstructive sleep apnea and other conditions of chronic hypoxia, hypercapnia, and acidosis. , 2004, Medical hypotheses.

[18]  Jürgen Kurths,et al.  Identifying complex periodic windows in continuous-time dynamical systems using recurrence-based methods. , 2010, Chaos.

[19]  H. Kantz,et al.  Nonlinear time series analysis , 1997 .

[20]  Bidyut Baran Chaudhuri,et al.  Optimum circular fit to weighted data in multi-dimensional space , 1993, Pattern Recognit. Lett..

[21]  N. Hayashi,et al.  Effect of intensity of dynamic exercise on pupil diameter in humans. , 2010, Journal of physiological anthropology.

[22]  Christian Guilleminault,et al.  Heart rate variability, sympathetic and vagal balance and EEG arousals in upper airway resistance and mild obstructive sleep apnea syndromes. , 2005, Sleep medicine.

[23]  W. Maixner,et al.  Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. , 2009, The journal of pain : official journal of the American Pain Society.

[24]  L. Mesin,et al.  Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study , 2012, PloS one.