Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

[1]  M. Daly,et al.  Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses , 2023, Nature Medicine.

[2]  H. Kasai,et al.  Mechanical transmission at spine synapses: Short-term potentiation and working memory , 2023, Current Opinion in Neurobiology.

[3]  Tao Li,et al.  New “drugs and targets” in the GWAS era of bipolar disorder , 2023, Bipolar disorders.

[4]  Chunting Zhou,et al.  Contribution of Nischarin/IRAS in CNS development, injury and diseases. , 2023, Journal of advanced research.

[5]  Zhongchun Liu,et al.  Genetic evidence for the “dopamine hypothesis of bipolar disorder” , 2022, Molecular Psychiatry.

[6]  Michael F. Green,et al.  Mapping genomic loci implicates genes and synaptic biology in schizophrenia , 2022, Nature.

[7]  Tao Li,et al.  Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings , 2022, Molecular Psychiatry.

[8]  M. Daly,et al.  Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains , 2022, European Neuropsychopharmacology.

[9]  Emily E. Burke,et al.  Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal down-regulated neuroimmune and synaptic pathways , 2022, Nature Neuroscience.

[10]  S. Okpechi,et al.  Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer , 2022, Oncogene.

[11]  David R. Liu,et al.  Programmable deletion, replacement, integration, and inversion of large DNA sequences with twin prime editing , 2021, Nature Biotechnology.

[12]  A. Soltanian,et al.  Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance - Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase. , 2021, Journal of psychiatric research.

[13]  Ming Li,et al.  Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution , 2021, Molecular Psychiatry.

[14]  T. Toyoizumi,et al.  Spine dynamics in the brain, mental disorders and artificial neural networks , 2021, Nature Reviews Neuroscience.

[15]  Zachary F. Gerring,et al.  Symptom-level modelling unravels the shared genetic architecture of anxiety and depression , 2021, Nature Human Behaviour.

[16]  Dan J Stein,et al.  Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology , 2021, Nature Genetics.

[17]  P. Penzes,et al.  Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome , 2021, Molecular Psychiatry.

[18]  Yong-Gang Yao,et al.  Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus , 2020, Biological Psychiatry.

[19]  P. Pariwatcharakul,et al.  Clonidine and Tizanidine for Management of Bipolar Disorder Due to Dengue Encephalopathy: A Case Report. , 2020, Psychosomatics.

[20]  S. Edwards,et al.  The Role of Noncoding Variants in Heritable Disease. , 2020, Trends in genetics : TIG.

[21]  Ming Li,et al.  A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density. , 2020, Schizophrenia bulletin.

[22]  Tao Li,et al.  Translational genomics and beyond in bipolar disorder , 2020, Molecular Psychiatry.

[23]  Y. Fang,et al.  Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci , 2020, Neuropsychopharmacology.

[24]  Ming Li,et al.  The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine , 2019, Molecular Psychiatry.

[25]  B. Glenthøj,et al.  Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication , 2019, Neuropsychopharmacology.

[26]  G. Lewis,et al.  Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness , 2019, JAMA psychiatry.

[27]  Annie W Shieh,et al.  Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder , 2018, Science.

[28]  Xiong Guo,et al.  A large-scale integrative analysis of GWAS and common meQTLs across whole life course identifies genes, pathways and tissue/cell types for three major psychiatric disorders , 2018, Neuroscience & Biobehavioral Reviews.

[29]  Christian Gieger,et al.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits , 2018, Nature Genetics.

[30]  P. Andersen,et al.  New drug candidates for depression – a nationwide population‐based study , 2018, Acta psychiatrica Scandinavica.

[31]  Jonathan P. Beauchamp,et al.  Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals , 2018, Nature Genetics.

[32]  Tyrone D. Cannon,et al.  Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence , 2018, Nature Genetics.

[33]  D. Kingsley,et al.  Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia , 2018, bioRxiv.

[34]  P. Penzes,et al.  Dendritic structural plasticity and neuropsychiatric disease , 2018, Nature Reviews Neuroscience.

[35]  Eun Ji Song,et al.  Intrahippocampal injection of a lentiviral vector expressing neurogranin enhances cognitive function in 5XFAD mice , 2018, Experimental & Molecular Medicine.

[36]  Yong-Gang Yao,et al.  Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes , 2018, Nature Communications.

[37]  Alex H. Wagner,et al.  DGIdb 3.0: a redesign and expansion of the drug–gene interaction database , 2017, bioRxiv.

[38]  David S. Wishart,et al.  DrugBank 5.0: a major update to the DrugBank database for 2018 , 2017, Nucleic Acids Res..

[39]  Byungwook Lee,et al.  3DIV: A 3D-genome Interaction Viewer and database , 2017, Nucleic Acids Res..

[40]  Elly Nedivi,et al.  Spine Dynamics: Are They All the Same? , 2017, Neuron.

[41]  K. Rawlik,et al.  An atlas of genetic associations in UK Biobank , 2017, bioRxiv.

[42]  M. Hill,et al.  Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure , 2017, Biological Psychiatry.

[43]  D. Rujescu,et al.  Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory , 2017, Neuropsychopharmacology.

[44]  Jef D. Boeke,et al.  Structural variants caused by Alu insertions are associated with risks for many human diseases , 2017, Proceedings of the National Academy of Sciences.

[45]  A. Sampson,et al.  Selective Loss of Smaller Spines in Schizophrenia. , 2017, The American journal of psychiatry.

[46]  Ting Wang,et al.  The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions , 2017, Genome Biology.

[47]  Rajarshi Guha,et al.  Pharos: Collating protein information to shed light on the druggable genome , 2016, Nucleic Acids Res..

[48]  Anthony D. Schmitt,et al.  A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome. , 2016, Cell reports.

[49]  John P. Overington,et al.  The druggable genome and support for target identification and validation in drug development , 2016, Science Translational Medicine.

[50]  J. Joly,et al.  Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR , 2016, Genome Biology.

[51]  P. Allen,et al.  Working Memory in Unaffected Relatives of Patients With Schizophrenia: A Meta-Analysis of Functional Magnetic Resonance Imaging Studies. , 2016, Schizophrenia bulletin.

[52]  Ming Li,et al.  A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus , 2016, Nature Medicine.

[53]  P. Worley,et al.  Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene , 2016, Synapse.

[54]  Yuying Li,et al.  Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity , 2015, PloS one.

[55]  G. Lubec,et al.  Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines , 2015, PloS one.

[56]  S. Mccarroll,et al.  Characterization of Bipolar Disorder Patient-Specific Induced Pluripotent Stem Cells from a Family Reveals Neurodevelopmental and mRNA Expression Abnormalities , 2014, Molecular Psychiatry.

[57]  J. Coyle,et al.  Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. , 2014, JAMA psychiatry.

[58]  B. Schürmann,et al.  Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses , 2014, Neuron.

[59]  B. Glenthøj,et al.  Clonidine normalizes levels of P50 gating in patients with schizophrenia on stable medication. , 2014, Schizophrenia bulletin.

[60]  M. Gill,et al.  Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway. , 2014, JAMA psychiatry.

[61]  B. Levine,et al.  Treating Working Memory Deficits in Schizophrenia: A Review of the Neurobiology , 2014, Biological Psychiatry.

[62]  A. Dunning,et al.  Beyond GWASs: illuminating the dark road from association to function. , 2013, American journal of human genetics.

[63]  Godfrey D Pearlson,et al.  Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. , 2013, The American journal of psychiatry.

[64]  B. Glenthøj,et al.  Clonidine normalizes sensorimotor gating deficits in patients with schizophrenia on stable medication. , 2013, Schizophrenia bulletin.

[65]  Q. Xia,et al.  Nischarin Is Differentially Expressed in Rat Brain and Regulates Neuronal Migration , 2013, PloS one.

[66]  E. Rolls,et al.  Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy , 2012, Nature Reviews Drug Discovery.

[67]  Qi Dong,et al.  The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder , 2012, Neuropsychopharmacology.

[68]  P. Deininger.  Alu elements: know the SINEs , 2011, Genome Biology.

[69]  Fabio Sambataro,et al.  Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. , 2011, Archives of general psychiatry.

[70]  D. Srivastava,et al.  Analysis of dendritic spine morphology in cultured CNS neurons. , 2011, Journal of visualized experiments : JoVE.

[71]  P. Penzes,et al.  Dendritic spine pathology in neuropsychiatric disorders , 2011, Nature Neuroscience.

[72]  Jun Noguchi,et al.  Structural dynamics of dendritic spines in memory and cognition , 2010, Trends in Neurosciences.

[73]  H. Nicolini,et al.  Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. , 2010, Archives of general psychiatry.

[74]  Thomas W. Mühleisen,et al.  Meta-analysis of genome-wide association data detects a risk locus for major mood disorders on chromosome 3p21.1 , 2009, Nature Genetics.

[75]  Li-Huei Tsai,et al.  Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling , 2009, Cell.

[76]  F. Verbeek,et al.  Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression , 2009, BMC Neuroscience.

[77]  Douglas B. Ehlenberger,et al.  Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images , 2008, PloS one.

[78]  S. Alahari,et al.  Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion , 2008, Molecular and Cellular Biology.

[79]  Leonardo Fazio,et al.  Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory , 2007, Proceedings of the National Academy of Sciences.

[80]  J. Os,et al.  Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives , 2007, Psychological Medicine.

[81]  J. Bourne,et al.  Do thin spines learn to be mushroom spines that remember? , 2007, Current Opinion in Neurobiology.

[82]  J. Häsler,et al.  Alu elements as regulators of gene expression , 2006, Nucleic acids research.

[83]  Dong Xu,et al.  Regulation of p21-activated Kinase-independent Rac1 Signal Transduction by Nischarin* , 2005, Journal of Biological Chemistry.

[84]  G. Ellis‐Davies,et al.  Structural basis of long-term potentiation in single dendritic spines , 2004, Nature.

[85]  M. Sheng,et al.  Dentritic spines : structure, dynamics and regulation , 2001, Nature Reviews Neuroscience.

[86]  Y. Lecrubier,et al.  Efficacy of clonidine in 24 patients with acute mania. , 1986, The American journal of psychiatry.

[87]  S. Stringer,et al.  Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence , 2019 .

[88]  Z. Bashir,et al.  Z. (2015). Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission: NMDARs control hippocampal-PFC synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America, 112(25), 11096–11101. 10.1073/pnas.1512064112 , 2016 .

[89]  J. Stockman,et al.  Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study , 2010 .

[90]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[91]  K. Svoboda,et al.  Structure and function of dendritic spines. , 2002, Annual review of physiology.

[92]  R. Yuste,et al.  Morphological changes in dendritic spines associated with long-term synaptic plasticity. , 2001, Annual review of neuroscience.

[93]  D. Lewis,et al.  Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. , 2000, Archives of general psychiatry.