Ethosuximide-induced lupus-scleroderma syndrome with disease-specific autoantibodies

Scleroderma is a multisystem autoimmune, vascular, and fibrotic disorder, occurring in genetically predisposed individuals exposed to an unknown set of environmental factors [1]. However, a lupus-like syndrome develops in clear association with drug exposure, including anticonvulsants [2, 3]. Scleroderma relevant to environmental influences, such as occupational scleroderma, is generally self-sustaining even after ceasing exposure to potential triggers [4, 5], while drug-induced lupus erythematosus [...]