A mega-analysis of genome-wide association studies for major depressive disorder

[1]  Jean-Baptiste Cazier,et al.  Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 , 2010, Nature Genetics.

[2]  D. Lin,et al.  Analysis of untyped SNPs: maximum likelihood and imputation methods , 2010, Genetic epidemiology.

[3]  Tariq Ahmad,et al.  Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci , 2010, Nature Genetics.

[4]  P. Holmans,et al.  Genetics of recurrent early‐onset depression (GenRED): Design and preliminary clinical characteristics of a repository sample for genetic linkage studies , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[5]  U. John,et al.  Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design , 2005, Sozial- und Präventivmedizin.

[6]  J. Kaprio,et al.  Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. , 2000, The New England journal of medicine.

[7]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[8]  H. Wittchen,et al.  Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies , 2005, European Neuropsychopharmacology.

[9]  A. Janssens,et al.  Meta-analyses of genetic studies on major depressive disorder , 2008, Molecular Psychiatry.

[10]  M. Weissman,et al.  Cross-national epidemiology of major depression and bipolar disorder. , 1996, JAMA.

[11]  M. Daly,et al.  Estimation of the multiple testing burden for genomewide association studies of nearly all common variants , 2008, Genetic epidemiology.

[12]  Deborah Hughes,et al.  Genome-wide association study identifies five new breast cancer susceptibility loci , 2010, Nature Genetics.

[13]  Lefkos Middleton,et al.  The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors , 2009, BMC psychiatry.

[14]  P. Visscher,et al.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.

[15]  Ayellet V. Segrè,et al.  Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.

[16]  Robert C. Thompson,et al.  Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry , 2009, Proceedings of the National Academy of Sciences.

[17]  W. Rathmann,et al.  Cohort profile: the study of health in Pomerania. , 2011, International journal of epidemiology.

[18]  Zhaohui S. Qin,et al.  A second generation human haplotype map of over 3.1 million SNPs , 2007, Nature.

[19]  S. Cichon,et al.  Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression , 2010, Biological Psychiatry.

[20]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[21]  N. Wray,et al.  Genomewide Association for Major Depressive Disorder: A possible role for the presynaptic protein Piccolo , 2008, Molecular Psychiatry.

[22]  W. Rushlow,et al.  The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling , 2011, Neuroscience.

[23]  Johanna M Seddon,et al.  The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. , 2005, Archives of ophthalmology.

[24]  L. Hawkley,et al.  Social regulation of gene expression in human leukocytes , 2007, Genome Biology.

[25]  Ayellet V. Segrè,et al.  Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.

[26]  P. McGuffin,et al.  A hospital-based twin register of the heritability of DSM-IV unipolar depression. , 1996, Archives of general psychiatry.

[27]  A. Hofman,et al.  The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression , 2011, Neuron.

[28]  J. Os,et al.  The size and burden of mental disorders and other disorders of the brain in Europe 2010 , 2011, European Neuropsychopharmacology.

[29]  P. Donnelly,et al.  Replicating genotype–phenotype associations , 2007, Nature.

[30]  K. Shedden,et al.  The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. , 2011, Archives of general psychiatry.

[31]  P. Muglia,et al.  Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts , 2010, Molecular Psychiatry.

[32]  Olga V. Demler,et al.  The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). , 2003, JAMA.

[33]  Henrik,et al.  Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index , 2012 .

[34]  D. Ye,et al.  Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China , 2007, Archives of Dermatological Research.

[35]  B. Grant,et al.  Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. , 2005, Archives of general psychiatry.

[36]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[37]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[38]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[39]  P. Poulsen,et al.  Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance – a population-based twin study , 1999, Diabetologia.

[40]  Juni Palmgren,et al.  The Swedish Twin Registry in the Third Millennium: An Update , 2006, Twin Research and Human Genetics.

[41]  P. Visscher,et al.  Common SNPs explain a large proportion of heritability for human height , 2011 .

[42]  H Völzke,et al.  Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden , 2005, Molecular Psychiatry.

[43]  M. Weissman,et al.  Children with prepubertal-onset major depressive disorder and anxiety grown up. , 1999, Archives of general psychiatry.

[44]  P. McGuffin,et al.  The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update , 2010, Molecular Psychiatry.

[45]  D Y Lin,et al.  Meta‐analysis of genome‐wide association studies: no efficiency gain in using individual participant data , 2009, Genetic epidemiology.

[46]  Susanne Walitza,et al.  Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.

[47]  E. Nestler,et al.  A Novel Role of the WNT-Dishevelled-GSK3β Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression , 2011, The Journal of Neuroscience.

[48]  Manuel A. R. Ferreira,et al.  Practical aspects of imputation-driven meta-analysis of genome-wide association studies. , 2008, Human molecular genetics.

[49]  P. Visscher,et al.  Comparing apples and oranges: equating the power of case‐control and quantitative trait association studies , 2009, Genetic epidemiology.

[50]  S. Faraone,et al.  The genetics of mood disorders , 1990 .

[51]  Vincent Mooser,et al.  The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome , 2008, BMC cardiovascular disorders.

[52]  W. Coryell,et al.  Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. , 1999, The American journal of psychiatry.

[53]  J. Smoller,et al.  Family, twin, and adoption studies of bipolar disorder , 2003, American journal of medical genetics. Part C, Seminars in medical genetics.

[54]  M. Goodell,et al.  Genome-wide association study of recurrent early-onset major depressive disorder , 2010, Molecular Psychiatry.

[55]  T. Peters,et al.  Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial , 2011, British Journal of Psychiatry.

[56]  D. Levinson.  The Genetics of Depression: A Review , 2006, Biological Psychiatry.

[57]  E. Vassos,et al.  Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression , 2010, Nature Genetics.

[58]  Alan D. Lopez,et al.  Evidence-Based Health Policy--Lessons from the Global Burden of Disease Study , 1996, Science.

[59]  J. Os,et al.  Cost of disorders of the brain in Europe 2010 , 2011, European Neuropsychopharmacology.

[60]  P. Muglia,et al.  Genome-wide association study of major recurrent depression in the U.K. population. , 2010, The American journal of psychiatry.

[61]  Manuel A. R. Ferreira,et al.  Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 , 2011, Nature Genetics.

[62]  R. Yolken,et al.  Meta-analysis of 12 genomic studies in bipolar disorder , 2007, Journal of Molecular Neuroscience.

[63]  N. Rajakumar,et al.  Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled‐3 , 2007, Journal of neurochemistry.

[64]  H. Stassen,et al.  Mortality of patients with mood disorders: follow-up over 34-38 years. , 2002, Journal of affective disorders.

[65]  N. Pedersen,et al.  Heritability of Parkinson disease in Swedish twins: a longitudinal study , 2011, Neurobiology of Aging.

[66]  Sharon R Grossman,et al.  Integrating common and rare genetic variation in diverse human populations , 2010, Nature.

[67]  N. Risch,et al.  Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. , 2009, JAMA.

[68]  Stephan Ripke,et al.  A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. , 2009, Archives of general psychiatry.

[69]  C. Hawkes,et al.  Twin studies and the heritability of MS: a conclusion , 2009, Multiple sclerosis.

[70]  M. Munafo,et al.  Gene × Environment Interactions at the Serotonin Transporter Locus , 2009, Biological Psychiatry.

[71]  Thomas W. Mühleisen,et al.  Meta-analysis of genome-wide association data detects a risk locus for major mood disorders on chromosome 3p21.1 , 2009, Nature Genetics.

[72]  P. Sullivan,et al.  Latent class analysis of lifetime depressive symptoms in the national comorbidity survey. , 1998, The American journal of psychiatry.

[73]  Allison L Miller,et al.  Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study , 2011, British Journal of Psychiatry.

[74]  L. Judd.  The clinical course of unipolar major depressive disorders. , 1997, Archives of general psychiatry.

[75]  B. Browning,et al.  A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. , 2009, American journal of human genetics.

[76]  N. Wray,et al.  Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned , 2010, Molecular Psychiatry.