论文信息 - A synthesis of imidazo- and pyrimido[1,2-g][1,6]naphthyridinones

A synthesis of imidazo- and pyrimido[1,2-g][1,6]naphthyridinones

Arylmethylimidazolines and (3-chlorophenyl)methyl-1,4,5,6-tetrahydropyrimidine amidated 2-chloro-3-pyridinecarbonyl chloride and potassium t-butoxide cyclized the products to linearly fused, tricyclic imidazo-and pyrimido[1,2-g][1,6]naphthyridinones. Condensation of ethyl 2-chloro-3-pyridinecarboxylate with 2-(phenylmethyl)imidazoline in the presence of sodium methoxide directly formed the isomeric, angularly fused 8,9-dihydro-6-phenylimidazo[1,2-a][1,8]naphthyridin--5(7H)-one.

F. Villani | J. Schwerdt | V. Seidl | R. Friary

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