Distribution in allele frequencies of predisposition‐to‐atopy genotypes in Chinese children

Asthma is one of the most common chronic diseases in childhood; it is caused by a complex interaction between genetic factors and exposure to environmental allergens and irritants. Previous studies using the candidate gene approach showed that asthma was linked to a number of susceptibility genetic loci in Caucasian subjects. There are, however, only a few studies on asthma predisposition genes in the Chinese population. We studied the distribution of allele frequencies of I50V for the interleukin‐4 receptor, two polymorphisms in intron 2 and exon 7 for the high‐affinity IgE receptor (FcεRI‐β), R16G and E27Q for the β2‐adrenoceptor ,and R275Q (824G/A) for CC chemokine receptor 3 in Chinese children.

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