Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis

[1]  Natalie E. Roese,et al.  Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice , 2022, Alzheimer's Research & Therapy.

[2]  Natalie E. Roese,et al.  Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice , 2022, Alzheimer's research & therapy.

[3]  B. Ertl-Wagner,et al.  Decreased Craniocervical CSF Flow in Patients with Normal Pressure Hydrocephalus: A Pilot Study , 2022, American Journal of Neuroradiology.

[4]  Georgios A. Keliris,et al.  An in-vivo digital atlas of the spatially reliable cerebral vasculature in mice , 2021, bioRxiv.

[5]  A. Mentis,et al.  APOE4-mediated Alzheimer disease and “Vascular”—“Meningeal Lymphatic” components: towards a novel therapeutic era? , 2021, Molecular Psychiatry.

[6]  Benjamin A. Logsdon,et al.  Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study , 2021, Frontiers in Aging Neuroscience.

[7]  Yuan Luo,et al.  Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease , 2021, Acta neuropathologica communications.

[8]  Feng Qi Han,et al.  Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology , 2021, PLoS biology.

[9]  D. Holtzman,et al.  Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy , 2021, Nature.

[10]  C. Harrington,et al.  The Neurovascular Unit Dysfunction in Alzheimer’s Disease , 2021, International journal of molecular sciences.

[11]  Y. Jeong,et al.  Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model , 2020, Acta neuropathologica communications.

[12]  H. Benveniste,et al.  In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage , 2020, Scientific Reports.

[13]  Ian F. Harrison,et al.  Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model , 2020, Brain : a journal of neurology.

[14]  B. Mattsson,et al.  Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system , 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  M. Nedergaard,et al.  The Brain’s Glymphatic System: Current Controversies , 2020, Trends in Neurosciences.

[16]  G. Chrousos,et al.  Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework , 2020, Molecular Psychiatry.

[17]  A. Lloret,et al.  Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker , 2020, International journal of molecular sciences.

[18]  Z. Pei,et al.  Glutamate and γ-aminobutyric acid differentially modulate glymphatic clearance of amyloid β through pulsation- and aquaporin-4 dependent mechanisms , 2020, bioRxiv.

[19]  Youngsun Lee,et al.  Improvement of glymphatic–lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer’s disease model , 2020, Scientific Reports.

[20]  Q. Jiang,et al.  Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human , 2020, Annals of neurology.

[21]  Junying Gao,et al.  Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance , 2019, Alzheimer's research & therapy.

[22]  Bruce R. Rosen,et al.  Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep , 2019, Science.

[23]  M. Weller,et al.  Lymphatic outflow of cerebrospinal fluid is reduced in glioma , 2019, Scientific Reports.

[24]  D. Holtzman,et al.  Alzheimer Disease: An Update on Pathobiology and Treatment Strategies , 2019, Cell.

[25]  A. Konnerth,et al.  A vicious cycle of β amyloid–dependent neuronal hyperactivation , 2019, Science.

[26]  Georgios A. Keliris,et al.  Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis , 2019, Acta Neuropathologica Communications.

[27]  G. Koh,et al.  Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid , 2019, Nature.

[28]  V. Perry,et al.  Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease , 2019, Acta neuropathologica communications.

[29]  Maiken Nedergaard,et al.  Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia , 2019, Science Advances.

[30]  Denis Gris,et al.  Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release , 2019, Cells.

[31]  P. Eide,et al.  Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study , 2019, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[32]  H. Hirase,et al.  Aquaporin-4-dependent glymphatic solute transport in the rodent brain , 2018, eLife.

[33]  Weiguo Peng,et al.  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension , 2018, Nature Communications.

[34]  S. Hladky,et al.  Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier , 2018, Fluids and Barriers of the CNS.

[35]  Anders M. Dale,et al.  Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. , 2018, JCI insight.

[36]  Joanna Wardlaw,et al.  The Glymphatic System and Waste Clearance with Brain Aging: A Review , 2018, Gerontology.

[37]  Scott T. Acton,et al.  Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease , 2018, Nature.

[38]  Nanhong Lou,et al.  Cannula Implantation into the Cisterna Magna of Rodents. , 2018, Journal of visualized experiments : JoVE.

[39]  S. Hilsenbeck,et al.  Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice , 2018, The Journal of experimental medicine.

[40]  Maxime Gauberti,et al.  General Anesthesia Inhibits the Activity of the “Glymphatic System” , 2018, Theranostics.

[41]  Hui Zheng,et al.  Practical considerations for choosing a mouse model of Alzheimer’s disease , 2017, Molecular Neurodegeneration.

[42]  M. Detmar,et al.  Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice , 2017, Nature Communications.

[43]  Maiken Nedergaard,et al.  Perivascular spaces, glymphatic dysfunction, and small vessel disease. , 2017, Clinical science.

[44]  M. Nedergaard,et al.  Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. , 2017, The Journal of clinical investigation.

[45]  Pierre Bellec,et al.  Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis , 2017, Alzheimer's & dementia.

[46]  M. Walker,et al.  Sleep and Human Aging , 2017, Neuron.

[47]  R. Wong,et al.  Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade , 2017, Front. Aging Neurosci..

[48]  H. Rusinek,et al.  Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET , 2017, The Journal of Nuclear Medicine.

[49]  M. Nedergaard,et al.  Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts , 2017, The Journal of Neuroscience.

[50]  J. Kaye,et al.  Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains , 2017, JAMA neurology.

[51]  J. F. Alonso,et al.  Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly. , 2016, Sleep.

[52]  Sean Regan,et al.  Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease , 2016, Neurobiology of Disease.

[53]  Annemie Van der Linden,et al.  Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition , 2016, Alzheimer's & Dementia.

[54]  Joanes Grandjean,et al.  Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison , 2016, NeuroImage.

[55]  Jürgen Hennig,et al.  Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms? , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[56]  Ankit Parekh,et al.  Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation , 2016, Neurobiology of Aging.

[57]  C. Jack,et al.  Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria , 2016, Alzheimer's & Dementia.

[58]  Harald Sontheimer,et al.  Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease. , 2015, Brain : a journal of neurology.

[59]  G. Hu,et al.  Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits , 2015, Molecular Neurodegeneration.

[60]  Thomas Wisniewski,et al.  Clearance systems in the brain—implications for Alzheimer disease , 2015, Nature Reviews Neurology.

[61]  Michael Detmar,et al.  A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules , 2015 .

[62]  Maiken Nedergaard,et al.  The Glymphatic System: A Beginner’s Guide , 2015, Neurochemical Research.

[63]  Maiken Nedergaard,et al.  Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury , 2014, The Journal of Neuroscience.

[64]  Maiken Nedergaard,et al.  Impairment of paravascular clearance pathways in the aging brain , 2014, Annals of neurology.

[65]  Maxime Gauberti,et al.  Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI: A New Target for Fibrinolysis? , 2014, Stroke.

[66]  Marleen Verhoye,et al.  Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis , 2013, PloS one.

[67]  Maiken Nedergaard,et al.  Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain , 2013, The Journal of Neuroscience.

[68]  Daniel J. R. Christensen,et al.  Sleep Drives Metabolite Clearance from the Adult Brain , 2013, Science.

[69]  Chengjie Xiong,et al.  Sleep quality and preclinical Alzheimer disease. , 2013, JAMA neurology.

[70]  Tian Feng,et al.  Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. , 2013, The Journal of clinical investigation.

[71]  G. E. Vates,et al.  A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β , 2012, Science Translational Medicine.

[72]  J. Jankowsky,et al.  Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult , 2012, Molecular Neurodegeneration.

[73]  Bert Sakmann,et al.  Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease , 2012, Proceedings of the National Academy of Sciences.

[74]  B. Zlokovic.  Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders , 2011, Nature Reviews Neuroscience.

[75]  T. Golde,et al.  Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy , 2011, The Journal of Neuroscience.

[76]  Jee Hoon Roh,et al.  Neuronal activity regulates the regional vulnerability to amyloid-β deposition , 2011, Nature Neuroscience.

[77]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[78]  L. Lannfelt,et al.  Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[79]  Muhammad Ali Amer,et al.  Genome-wide association study of 107 phenotypes in a common set of Arabidopsis thaliana inbred lines , 2010, Nature.

[80]  Shaomin Li,et al.  Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake , 2009, Neuron.

[81]  T. Golde.  Alzheimer's Research & Therapy , 2009 .

[82]  R. Carare,et al.  Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. , 2008, Brain pathology.

[83]  C. Iadecola,et al.  Glial regulation of the cerebral microvasculature , 2007, Nature Neuroscience.

[84]  Hartwig Wolburg,et al.  Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology , 2006, EMBO reports.

[85]  H. Lester,et al.  Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease , 2005, PLoS medicine.

[86]  M. Greicius,et al.  Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI , 2004, Proc. Natl. Acad. Sci. USA.

[87]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[88]  D. Holtzman,et al.  Clearance of amyloid β-peptide from brain: transport or metabolism? , 2000, Nature Medicine.

[89]  D. Holtzman,et al.  Clearance of amyloid beta-peptide from brain: transport or metabolism? , 2000, Nature medicine.

[90]  J. Kaye,et al.  Cerebrospinal fluid production is reduced in healthy aging , 1990, Neurology.