Major bone lesions in acute lymphoblastic leukaemia.

The records of 1471 patients with ALL entered into UKALL trials II-V (1972-1977) were studied, and major bone lesions at diagnosis were recorded in 47 (3.2%). These were found predominantly in young patients (median age 5 years), equally in both sexes, and were seen to be associated with a low blood leucocyte count and prolonged remissions.