Detection of epileptic seizures from single lead ECG by means of phase rectified signal averaging

Epileptic seizures have a clear effect on the regulatory mechanisms of the autonomic nervous system, especially on the cardiac and respiratory controls. Changes in heart rate and respiration are well known to occur around the onset of the seizure. This paper studies the ECG signals recorded from patients suffering from epilepsy, whose ages ranged from 3 to 48 years. Both focal and generalized seizures are considered. Changes in cardiorespiratory control and coupling, are assessed using phase rectified signal averaging (PRSA), wich is a technique that finds quasi-periodicities in noisy and non-stationary signals. A positive predictive value (PPV) of 86.21% with sensitivity of 100% was obtained for focal seizures, and a PPV of 84.3% with 93.1% sensitivity for generalized seizures.

[1]  Sabine Van Huffel,et al.  Detection of epileptic seizures by means of morphological changes in the ECG , 2013, Computing in Cardiology 2013.

[2]  Johan A. K. Suykens,et al.  Multiway Spectral Clustering with Out-of-Sample Extensions through Weighted Kernel PCA , 2010, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[3]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[4]  C. Baumgartner,et al.  Electrocardiographic Changes at the Onset of Epileptic Seizures , 2003, Epilepsia.

[5]  Georg Schmidt,et al.  Bivariate phase-rectified signal averaging--a novel technique for cross-correlation analysis in noisy nonstationary signals. , 2009, Journal of electrocardiology.

[7]  Marek Malik,et al.  Phase-rectified signal averaging for the detection of quasi-periodicities and the prediction of cardiovascular risk. , 2007, Chaos.

[8]  M. O'Regan,et al.  Abnormalities in cardiac and respiratory function observed during seizures in childhood. , 2005 .

[9]  G Schmidt,et al.  New computerized fetal heart rate analysis for surveillance of intrauterine growth restriction , 2011, Prenatal diagnosis.

[10]  Sabine Van Huffel,et al.  Ictal and interictal respiratory changes in temporal lobe and absence epilepsy in childhood , 2013, Epilepsy Research.

[11]  M. Malik,et al.  Phase-rectified signal averaging detects quasi-periodicities in non-stationary data , 2006 .

[12]  Jan W. Kantelhardt,et al.  Bivariate phase-rectified signal averaging , 2008, 0804.2798.

[13]  Sabine Van Huffel,et al.  Application of Kernel Principal Component Analysis for Single-Lead-ECG-Derived Respiration , 2012, IEEE Transactions on Biomedical Engineering.

[14]  Jeffrey M. Hausdorff,et al.  Postictal heart rate oscillations in partial epilepsy. , 1999, Neurology.