Structural analysis of CYP2R1 in complex with vitamin D3.

[1]  P. D. de Montellano,et al.  Mycobacterium tuberculosis CYP130 , 2008, Journal of Biological Chemistry.

[2]  P. Beaune,et al.  Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues , 2007, Pharmacogenetics and genomics.

[3]  D. Trump,et al.  Vitamin D signalling pathways in cancer: potential for anticancer therapeutics , 2007, Nature Reviews Cancer.

[4]  L. Delattre,et al.  Study of the relationship between lipid binding properties of cyclodextrins and their effect on the integrity of liposomes. , 2007, International journal of pharmaceutics.

[5]  Glenville Jones,et al.  Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies. , 2007, Archives of biochemistry and biophysics.

[6]  R. Serda,et al.  Hybrid homology modeling and mutational analysis of cytochrome P450C24A1 (CYP24A1) of the Vitamin D pathway: insights into substrate specificity and membrane bound structure-function. , 2007, Archives of biochemistry and biophysics.

[7]  D. Moras,et al.  Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol. , 2007, Archives of biochemistry and biophysics.

[8]  Rebecca C Wade,et al.  The ins and outs of cytochrome P450s. , 2007, Biochimica et biophysica acta.

[9]  Andreas Engel,et al.  Controlled 2D crystallization of membrane proteins using methyl-β-cyclodextrin , 2007 .

[10]  R. Mehta,et al.  Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs. , 2006, Anticancer research.

[11]  K. Inouye,et al.  Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats , 2006, Molecular Pharmacology.

[12]  Z. Jia,et al.  Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation. , 2006, Biophysical journal.

[13]  M. Waterman,et al.  CYP51 from Trypanosoma cruzi , 2006, Journal of Biological Chemistry.

[14]  C David Stout,et al.  Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases. , 2005, Biochemical and biophysical research communications.

[15]  L. Waskell,et al.  Role of cytochrome b5 in catalysis by cytochrome P450 2B4. , 2005, Biochemical and biophysical research communications.

[16]  Rajeswari Challa,et al.  Cyclodextrins in drug delivery: An updated review , 2005, AAPS PharmSciTech.

[17]  N. Kagawa,et al.  Identification of the Amino Acid Residue of CYP27B1 Responsible for Binding of 25-Hydroxyvitamin D3 Whose Mutation Causes Vitamin D-dependent Rickets Type 1* , 2005, Journal of Biological Chemistry.

[18]  I. Pikuleva,et al.  A simple and rapid method to measure cholesterol binding to P450s and other proteins Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.D500008-JLR200 , 2005, Journal of Lipid Research.

[19]  J. Schenkman,et al.  Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. , 2005, Archives of biochemistry and biophysics.

[20]  Glenville Jones,et al.  Enzymes involved in the activation and inactivation of vitamin D. , 2004, Trends in biochemical sciences.

[21]  K. Inouye,et al.  Metabolism of vitamin D by human microsomal CYP2R1. , 2004, Biochemical and biophysical research communications.

[22]  E. Dalmasso,et al.  Estriol Bound and Ligand-free Structures of Sterol 14α-Demethylase , 2004 .

[23]  Y. Ohyama,et al.  Eight cytochrome P450s catalyze vitamin D metabolism. , 2004, Frontiers in bioscience : a journal and virtual library.

[24]  Eric F. Johnson,et al.  The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution* , 2004, Journal of Biological Chemistry.

[25]  M. Waterman,et al.  CYP51 from Trypanosoma brucei is obtusifoliol-specific. , 2004, Biochemistry.

[26]  T. Poulos,et al.  Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. , 2004, Biochemistry.

[27]  David C. Richardson,et al.  MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes , 2004, Nucleic Acids Res..

[28]  Jeffrey B. Cheng,et al.  Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Chiu,et al.  Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity. , 2004, Archives of biochemistry and biophysics.

[30]  H. DeLuca,et al.  Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide. , 2004, Biochemistry.

[31]  C David Stout,et al.  Structure of Human Microsomal Cytochrome P450 2C8 , 2004, Journal of Biological Chemistry.

[32]  T. Yamazaki,et al.  Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry. , 2003, Biochemistry.

[33]  W. Miller,et al.  Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase. , 2003, Molecular genetics and metabolism.

[34]  R. Estabrook,et al.  A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1) , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[35]  T. Poulos.  Cytochrome P450 flexibility , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[36]  M. Wilce,et al.  The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane. , 2003, Biochimica et biophysica acta.

[37]  Jeffrey B. Cheng,et al.  De-orphanization of Cytochrome P450 2R1 , 2003, Journal of Biological Chemistry.

[38]  Y. Inoue,et al.  NMR and quantum chemical study on the OH...pi and CH...O interactions between trehalose and unsaturated fatty acids: implication for the mechanism of antioxidant function of trehalose. , 2003, Journal of the American Chemical Society.

[39]  D. Lewis,et al.  Functional interaction of cytochrome P450 with its redox partners: a critical assessment and update of the topology of predicted contact regions. , 2003, Journal of inorganic biochemistry.

[40]  Jose Cosme,et al.  Crystal structure of human cytochrome P450 2C9 with bound warfarin , 2003, Nature.

[41]  H. Deng,et al.  Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase. , 2003, Biochemistry.

[42]  C David Stout,et al.  Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes. , 2003, Biochemistry.

[43]  J. Engel,et al.  Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled‐coil domain in complex with vitamin D3 , 2002, The EMBO journal.

[44]  R. Estabrook,et al.  Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling. , 2002, Biochemistry.

[45]  R. Bouillon,et al.  A structural basis for the unique binding features of the human vitamin D-binding protein , 2002, Nature Structural Biology.

[46]  I. Björkhem,et al.  Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1. , 2001, Biochemistry.

[47]  D. Moras,et al.  Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[48]  R. Estabrook,et al.  Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions. , 2001, Biochemistry.

[49]  A. Norman,et al.  Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein , 2001, The Journal of Steroid Biochemistry and Molecular Biology.

[50]  K. Wikvall.  Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review). , 2001, International journal of molecular medicine.

[51]  H. DeLuca,et al.  Current understanding of the molecular actions of vitamin D. , 1998, Physiological reviews.

[52]  W. Miller,et al.  Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. , 1997, Molecular endocrinology.

[53]  A. Vagin,et al.  MOLREP: an Automated Program for Molecular Replacement , 1997 .

[54]  F. Glorieux,et al.  The 25‐Hydroxyvitamin D 1‐Alpha‐Hydroxylase Gene Maps to the Pseudovitamin D‐Deficiency Rickets (PDDR) Disease Locus , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[55]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[56]  T. Richardson,et al.  Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modification of its N-terminus. , 1997, Archives of biochemistry and biophysics.

[57]  C. Vial,et al.  Refolding of SDS- and thermally denatured MM-creatine kinase using cyclodextrins. , 1996, Biochemical and biophysical research communications.

[58]  J. Pitha,et al.  Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin* , 1996, The Journal of Biological Chemistry.

[59]  S. Gellman,et al.  Artificial Chaperone-assisted Refolding of Carbonic Anhydrase B , 1996, The Journal of Biological Chemistry.

[60]  R. Bouillon,et al.  Structure-function relationships in the vitamin D endocrine system. , 1995, Endocrine reviews.

[61]  G J Kleywegt,et al.  Detection, delineation, measurement and display of cavities in macromolecular structures. , 1994, Acta crystallographica. Section D, Biological crystallography.

[62]  G. Jones,et al.  Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[63]  B. Hollis,et al.  Human plasma transport of vitamin D after its endogenous synthesis. , 1993, The Journal of clinical investigation.

[64]  O. Gotoh,et al.  Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. , 1992, The Journal of biological chemistry.

[65]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[66]  H Koga,et al.  Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[67]  J. Compston.  Hepatic osteodystrophy: vitamin D metabolism in patients with liver disease. , 1986, Gut.

[68]  B C Finzel,et al.  The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450. , 1985, The Journal of biological chemistry.

[69]  H. DeLuca,et al.  Metabolites of vitamin D3 and their biologic activity. , 1969, The Journal of nutrition.

[70]  T. Omura,et al.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. , 1964, The Journal of biological chemistry.

[71]  D E McRee,et al.  Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity. , 2000, Molecular cell.

[72]  D. Moras,et al.  The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. , 2000, Molecular cell.

[73]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.