An ultrasensitive nucleic acid biosensor based on the catalytic oxidation of guanine by a novel redox threading intercalator.

An ultrasensitive nucleic acid biosensor for the direct detection of attomoles nucleic acid in 1.0-5.0 [corrected] microl droplets is described which can be used for detection of cancer marker genes in mRNA extracted from human breast tissues without a RT-PCR step.

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