ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes. Here, Boxer et al. characterized ZNF750 as a transcription factor that binds both the progenitor and differentiation genes that it controls at a CCNNAGGC DNA motif. ZNF750 controls differentiation in concert with RCOR1 and CTBP1/2 by acting with either KDM1A to repress progenitor genes or KLF4 to induce differentiation genes.

[1]  Li Shang,et al.  Genomic and molecular characterization of esophageal squamous cell carcinoma , 2014, Nature Genetics.

[2]  Amber L. Couzens,et al.  The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data , 2013, Nature Methods.

[3]  G. Crabtree,et al.  ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. , 2013, Cell stem cell.

[4]  Greg Donahue,et al.  Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome , 2012, Cell.

[5]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[6]  Michael D. Zeller,et al.  GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program , 2012, PLoS genetics.

[7]  S. Grossman,et al.  CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1. , 2012, Genes & cancer.

[8]  Z. Siprashvili,et al.  ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. , 2012, Developmental cell.

[9]  Howard Y. Chang,et al.  Suppression of progenitor differentiation requires the long noncoding RNA ANCR. , 2012, Genes & development.

[10]  P. Kwok,et al.  Association analysis identifies ZNF750 regulatory variants in psoriasis , 2011, BMC Medical Genetics.

[11]  J. Zeitlinger,et al.  A computational pipeline for comparative ChIP-seq analyses , 2011, Nature Protocols.

[12]  J. Rinn,et al.  To repress or not to repress: this is the guardian's question. , 2011, Trends in cell biology.

[13]  Hyungwon Choi,et al.  SAINT: Probabilistic Scoring of Affinity Purification - Mass Spectrometry Data , 2010, Nature Methods.

[14]  A. Bergman,et al.  Corepressor for element-1–silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions , 2010, Proceedings of the National Academy of Sciences.

[15]  Chenfang Dong,et al.  The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1 , 2010, EMBO Journal.

[16]  Mei Han,et al.  Krüppel-like Factor 4 Promotes Differentiation by Transforming Growth Factor-β Receptor-mediated Smad and p38 MAPK Signaling in Vascular Smooth Muscle Cells* , 2010, The Journal of Biological Chemistry.

[17]  Hai Zheng,et al.  C‐terminal binding proteins (CtBPs) attenuate KLF4‐mediated transcriptional activation , 2009, FEBS letters.

[18]  F. Boisvert,et al.  Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes , 2008, The Journal of cell biology.

[19]  Howard Y. Chang,et al.  Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. , 2008, Genes & development.

[20]  Y. Chien,et al.  A promoter sequence variant of ZNF750 is linked with familial psoriasis. , 2008, The Journal of investigative dermatology.

[21]  N. D. Clarke,et al.  Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells , 2008, Cell.

[22]  Sheng Zhong,et al.  A core Klf circuitry regulates self-renewal of embryonic stem cells , 2008, Nature Cell Biology.

[23]  X. Chen,et al.  Krüppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation* , 2007, Journal of Biological Chemistry.

[24]  K. Kaestner,et al.  The Kruppel‐like factor KLF4 is a critical regulator of monocyte differentiation , 2007, The EMBO journal.

[25]  W. Jin,et al.  Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells. , 2007, Biochemical pharmacology.

[26]  J. Segre,et al.  Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition , 2006, Proceedings of the National Academy of Sciences.

[27]  Zhengquan Yu,et al.  The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. , 2006, Developmental biology.

[28]  M. Nardini,et al.  Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins , 2006, Molecular and Cellular Biology.

[29]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[30]  T. Blauwkamp,et al.  C‐terminal‐binding protein directly activates and represses Wnt transcriptional targets in Drosophila , 2006, The EMBO journal.

[31]  D. Geiger,et al.  Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein , 2006, Nature Genetics.

[32]  P. Chambon,et al.  Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation , 2005, Development.

[33]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[34]  Min Gyu Lee,et al.  An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation , 2005, Nature.

[35]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[36]  Yang Shi,et al.  Coordinated histone modifications mediated by a CtBP co-repressor complex , 2003, Nature.

[37]  Nathalie Perreault,et al.  The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. , 2002, Development.

[38]  S. Schreiber,et al.  CoREST is an integral component of the CoREST- human histone deacetylase complex. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[39]  D. Geiman,et al.  Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. , 2000, Nucleic acids research.

[40]  Elaine Fuchs,et al.  Klf4 is a transcription factor required for establishing the barrier function of the skin , 1999, Nature Genetics.

[41]  D. Dean,et al.  ZEB represses transcription through interaction with the corepressor CtBP. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Segre,et al.  Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. , 2007, Biochimica et biophysica acta.