Depletion layer formation in suspensions of elastic capsules in Newtonian and viscoelastic fluids

Motivated by observations of the effects of drag-reducing polymer additives on various aspects of blood flow, suspensions of fluid-filled elastic capsules in Newtonian fluids and dilute solutions of high molecular weight (drag-reducing) polymers are investigated during plane Couette flow in a slit geometry. A simple model is presented to describe the cross-stream distribution of capsules as a balance of shear-induced diffusion and wall-induced migration due to capsule deformability. The model provides a theoretical prediction of the dependence of capsule-depleted layer thickness on the capillary number. A computational approach is then used to directly study the motion of elastic capsules in a Newtonian fluid and in polymer solutions. Capsule membranes are modeled using a neo-Hookean constitutive model and polymer molecules are modeled as bead-spring chains with finitely extensible nonlinearly elastic springs, with parameters chosen to loosely approximate 4000 kDa poly(ethylene oxide). Simulations are per...

[1]  S. D. Hudson,et al.  Wall migration and shear-induced diffusion of fluid droplets in emulsions , 2003 .

[2]  Measurement of shear-induced dispersion in a dilute emulsion , 2001 .

[3]  D. Barthès-Biesel,et al.  Pairwise interaction of capsules in simple shear flow: Three-dimensional effects , 2008 .

[4]  J. Pacella,et al.  A novel hydrodynamic approach to the treatment of coronary artery disease. , 2006, European heart journal.

[5]  Hong Zhao,et al.  A spectral boundary integral method for flowing blood cells , 2010, J. Comput. Phys..

[6]  Petia M. Vlahovska,et al.  Vesicles in Poiseuille flow. , 2008, Physical review letters.

[7]  Hans Christian Öttinger,et al.  Stochastic Processes in Polymeric Fluids , 1996 .

[8]  Xiaofan Li,et al.  Wall-bounded shear flow and channel flow of suspensions of liquid drops , 2000 .

[9]  John Tsamopoulos,et al.  Spherical capsules in three-dimensional unbounded Stokes flows: effect of the membrane constitutive law and onset of buckling , 2004, Journal of Fluid Mechanics.

[10]  S. Lalka,et al.  Improvement of flow through arterial stenoses by drag reducing agents. , 1992, The Journal of surgical research.

[11]  Pier Luca Maffettone,et al.  Viscoelasticity-induced migration of a rigid sphere in confined shear flow , 2010 .

[12]  Dominique Barthès-Biesel,et al.  Hydrodynamic interaction between two identical capsules in simple shear flow , 2007, Journal of Fluid Mechanics.

[13]  Cyrus K Aidun,et al.  Cluster size distribution and scaling for spherical particles and red blood cells in pressure-driven flows at small Reynolds number. , 2006, Physical review letters.

[14]  M. Graham,et al.  Segregation by membrane rigidity in flowing binary suspensions of elastic capsules. , 2011, Physical review. E, Statistical, nonlinear, and soft matter physics.

[15]  Benjamin W. Zweifach,et al.  Microcirculation: Mechanics of Blood Flow in Capillaries , 1971 .

[16]  M. Dupin,et al.  Modeling the flow of dense suspensions of deformable particles in three dimensions. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[17]  J. Freund Leukocyte Margination in a Model Microvessel , 2006 .

[18]  C. Pozrikidis,et al.  Numerical Simulation of the Flow-Induced Deformation of Red Blood Cells , 2003, Annals of Biomedical Engineering.

[19]  Juan J de Pablo,et al.  Fast computation of many-particle hydrodynamic and electrostatic interactions in a confined geometry. , 2007, Physical review letters.

[20]  H Schmid-Schönbein,et al.  The stress-free shape of the red blood cell membrane. , 1981, Biophysical journal.

[21]  D. Leighton,et al.  A constitutive equation for droplet distribution in unidirectional flows of dilute emulsions for low capillary numbers , 2010 .

[22]  N. Antonova,et al.  Hemorheological and hemodynamic effects of high molecular weight polyethylene oxide solutions. , 2004, Clinical hemorheology and microcirculation.

[23]  C. Pozrikidis,et al.  Finite deformation of liquid capsules enclosed by elastic membranes in simple shear flow , 1995, Journal of Fluid Mechanics.

[24]  M. Zurita-Gotor,et al.  Layering instability in a confined suspension flow. , 2011, Physical review letters.

[25]  C. Peskin Numerical analysis of blood flow in the heart , 1977 .

[26]  Zhongjun J. Wu,et al.  Drag reducing polymers improve tissue perfusion via modification of the RBC traffic in microvessels. , 2009, Biorheology.

[27]  L. G. Leal,et al.  Particle Motions in a Viscous Fluid , 1980 .

[28]  J. Brady,et al.  Pressure-driven flow of suspensions: simulation and theory , 1994, Journal of Fluid Mechanics.

[29]  L. G. Leal,et al.  Inertial migration of rigid spheres in two-dimensional unidirectional flows , 1974, Journal of Fluid Mechanics.

[30]  Aaron L. Fogelson,et al.  Analysis of mechanisms for platelet near-wall excess under arterial blood flow conditions , 2011, Journal of Fluid Mechanics.

[31]  A. Pries,et al.  Corrections and Retraction , 2004 .

[32]  Charles S. Peskin,et al.  Validation of a simple method for representing spheres and slender bodies in an immersed boundary method for Stokes flow on an unbounded domain , 2008, J. Comput. Phys..

[33]  J. R. Smart,et al.  Measurement of the drift of a droplet due to the presence of a plane , 1991 .

[34]  W. Wood,et al.  Studies on the pathogenesis of acute inflammation. II. The action of cortisone on the inflammatory response to thermal injury. , 1955 .

[35]  P. S. Virk Drag reduction fundamentals , 1975 .

[36]  A. Sawchuk,et al.  Drag reducing polymers may decrease atherosclerosis by increasing shear in areas normally exposed to low shear stress. , 1999, Journal of vascular surgery.

[37]  S. Hénon,et al.  A new determination of the shear modulus of the human erythrocyte membrane using optical tweezers. , 1999, Biophysical journal.

[38]  J. R. Abbott,et al.  A constitutive equation for concentrated suspensions that accounts for shear‐induced particle migration , 1992 .

[39]  P. Polimeni,et al.  Effects of a Drag‐Reducing Polyelectrolyte of Microscopic Linear Dimension (Separan AP‐273) on Rat Hemodynamics , 1987, Circulation research.

[40]  J. Antaki,et al.  Drag-reducing polymers diminish near-wall concentration of platelets in microchannel blood flow. , 2010, Biorheology.

[41]  J. Clausen,et al.  Simulating deformable particle suspensions using a coupled lattice-Boltzmann and finite-element method , 2009, Journal of Fluid Mechanics.

[42]  Dominique Barthès-Biesel,et al.  Effect of constitutive laws for two-dimensional membranes on flow-induced capsule deformation , 2002, Journal of Fluid Mechanics.

[43]  J. Williamson,et al.  Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas. , 1961, The American journal of pathology.

[44]  Sai K. Doddi,et al.  Lateral migration of a capsule in a plane Poiseuille flow in a channel , 2008 .

[45]  P. Gaehtgens,et al.  Blood viscosity in small tubes: effect of shear rate, aggregation, and sedimentation. , 1987, The American journal of physiology.

[46]  Saroja Ramanujan,et al.  Deformation of liquid capsules enclosed by elastic membranes in simple shear flow: large deformations and the effect of fluid viscosities , 1998, Journal of Fluid Mechanics.

[47]  C. Pozrikidis,et al.  Effect of membrane bending stiffness on the deformation of capsules in simple shear flow , 2001, Journal of Fluid Mechanics.

[48]  Michael D. Graham,et al.  Theory of shear-induced migration in dilute polymer solutions near solid boundaries , 2005 .

[49]  R M Hochmuth,et al.  Erythrocyte membrane elasticity and viscosity. , 1987, Annual review of physiology.

[50]  L. G. Leal,et al.  The motion of a deformable drop in a second-order fluid , 1979, Journal of Fluid Mechanics.

[51]  B. Griffith,et al.  Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments. , 2004, Biorheology.

[52]  P. Dimitrakopoulos,et al.  Spindles, cusps, and bifurcation for capsules in Stokes flow. , 2008, Physical review letters.

[53]  Dominique Barthès-Biesel,et al.  Deformation of a capsule in simple shear flow: Effect of membrane prestress , 2005 .

[54]  H. L. Greene,et al.  Effects of drag reducing polymers on initiation of atherosclerosis , 1980 .

[55]  Dominique Barthès-Biesel,et al.  The time-dependent deformation of a capsule freely suspended in a linear shear flow , 1981, Journal of Fluid Mechanics.

[56]  M. Graham,et al.  Pair collisions of fluid-filled elastic capsules in shear flow: Effects of membrane properties and polymer additives , 2010 .

[57]  C. Pozrikidis,et al.  Numerical Simulation of Blood Flow Through Microvascular Capillary Networks , 2009, Bulletin of mathematical biology.

[58]  S Chien,et al.  In vivo measurements of "apparent viscosity" and microvessel hematocrit in the mesentery of the cat. , 1980, Microvascular research.

[59]  P. Polimeni,et al.  Hemodynamic Effects of a Poly(Ethylene Oxide) Drag‐Reducing Polymer, Poly ox WSR N‐60K, in the Open‐Chest Rat , 1989, Journal of cardiovascular pharmacology.

[60]  Cyrus K. Aidun,et al.  Capsule dynamics and rheology in shear flow: Particle pressure and normal stress , 2010 .

[61]  Marina V Kameneva,et al.  SURVIVAL IN A RAT MODEL OF LETHAL HEMORRHAGIC SHOCK IS PROLONGED FOLLOWING RESUSCITATION WITH A SMALL VOLUME OF A SOLUTION CONTAINING A DRAG-REDUCING POLYMER DERIVED FROM ALOE VERA , 2004, Shock.

[62]  S. Suresh,et al.  Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyte. , 2005, Biophysical journal.

[63]  E. J. Hinch,et al.  Shear-induced dispersion in a dilute suspension of rough spheres , 1996, Journal of Fluid Mechanics.

[64]  Sai K. Doddi,et al.  Three-dimensional computational modeling of multiple deformable cells flowing in microvessels. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[65]  A. Acrivos,et al.  The shear-induced migration of particles in concentrated suspensions , 1987, Journal of Fluid Mechanics.

[66]  Sai K. Doddi,et al.  Effect of inertia on the hydrodynamic interaction between two liquid capsules in simple shear flow , 2008 .

[67]  D. Barthès-Biesel Theoretical modelling of the motion and deformation of capsules in shear flows. , 1993, Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.

[68]  A. Pries,et al.  Transient rheological behavior of blood in low-shear tube flow: velocity profiles and effective viscosity. , 1995, The American journal of physiology.

[69]  C. Peskin The immersed boundary method , 2002, Acta Numerica.