Cerebrospinal Fluid Digoxin Concentrations in Humans

ma ‘t’he #{149}tuotnalof (‘lhh’n1 PIttttttttteologsN itiet’easing body of evidence stig csts that certaiti therapeutic and toxie effects of digitalis glycoshlos may be niediated through the central nervous sys= tem.’’9 A great deal is known about the pharmnokinctics of digitalis glycosides In human blood and pIasma, but factors hm flueiwing the rate and extent of their entry into the human ectitral nervous sys tern are largely unknown. We therefore studied concentrations of tllgoxin In serum and reln’ospinal fluid In a series of patients receiving spinal anesthesia for surgical procedures.

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