Toward Feedback Controlled Anesthesia: Automated Flow Analytical System for Electrochemical Monitoring of Propofol in Serum Solutions

For monitoring of the popular anesthetic drug propofol an automatic flow analytical system (AFAS) has been built that allows the quantitative measurement of electrochemically active compounds in continuous flow, stopped flow and flow injection analysis (FIA) modes. The performance characteristics of the AFAS is demon- strated using a microfabricated planar electrochemical cells in combination with a ~ 15 mL volume flow cell. To perform continuous monitoring experiments and the anal- ysis of individual propofol samples an organic membrane- coated voltammetric sensor has been implemented into the AFAS. The membrane coating prevents electrode fouling, provides outstanding detection limit and selectivi- ty for the voltammetric working electrode.

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