A Real-time Sorting Algorithm for In-Beam PET of Heavy-Ion Cancer Therapy Device

Abstract: A real-time digital time-stamp sorting algorithm used in the In-Beam positron emission tomography (In-Beam PET) is presented. The algorithm is operated in the field programmable gate array (FPGA) and a small amount of registers, MUX and memory cells are used. It is developed for sorting the data of annihilation event from front-end circuits, so as to identify the coincidence events efficiently in a large amount of data. In the In-Beam PET, each annihilation event is detected by the detector array and digitized by the analog to digital converter (ADC) in Data Acquisition Unit (DAQU), with a resolution of 14 bits and sampling rate of 50 MS/s. Test and preliminary operation have been implemented, it can perform a sorting operation under the event count rate up to 1 MHz per channel, and support four channels in total, count rate up to 4 MHz. The performance of this algorithm has been verified by pulse generator and 22Na radiation source, which can sort the events with chaotic order into chronological order completely. The application of this algorithm provides not only an efficient solution for selection of coincidence events, but also a design of electronic circuit with a small-scale structure.

[1]  Jian Song,et al.  A high-resolution time-to-digital converter implemented in field-programmable-gate-arrays , 2006, IEEE Transactions on Nuclear Science.

[2]  翁是强,et al.  AN AUTOMATIC SEGMENTATION METHOD FOR FAST IMAGING IN PET , 1993 .

[3]  J. Kong,et al.  Prototype design of readout electronics for In-Beam TOF-PET of Heavy-Ion Cancer Therapy Device , 2020 .

[4]  Claudia Feregrino Uribe,et al.  Author ' s personal copy A versatile linear insertion sorter based on an FIFO scheme , 2009 .

[5]  W. Moses.  Time of flight in PET revisited , 2003 .

[6]  Zheng-guo Hu,et al.  Development of a position sensitive CsI(Tl) crystal array , 2020 .

[7]  Youngjin Lee,et al.  Comparison of PET image quality using simultaneous PET/MR by attenuation correction with various MR pulse sequences , 2019, Nuclear Engineering and Technology.

[8]  David L. Andrews,et al.  A configurable high-throughput linear sorter system , 2010, 2010 IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum (IPDPSW).

[9]  G Baroni,et al.  Monte Carlo simulation tool for online treatment monitoring in hadrontherapy with in-beam PET: A patient study. , 2018, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[10]  Yong Hyun Chung,et al.  Feasibility study of multiplexing method using digital signal encoding technique , 2020 .

[11]  Volkmar Schulz,et al.  Software-Based Real-Time Acquisition and Processing of PET Detector Raw Data , 2016, IEEE Transactions on Biomedical Engineering.

[12]  J. Kong,et al.  A TOF-PET prototype with position sensitive PMT readout , 2011 .

[13]  C. J. Borkowski,et al.  Some Applications and Properties of One- and Two-Dimensional Position-Sensitive Proportional Counters , 1970 .

[14]  Yuxuan Zhang,et al.  A Real Time Coincidence System for High Count-Rate TOF or Non-TOF PET Cameras Using Hybrid Method Combining AND-Logic and Time-Mark Technology , 2009, IEEE Transactions on Nuclear Science.

[15]  W. Zhan,et al.  Progresses of heavy-ion cancer therapy , 2008 .

[16]  Hong Su,et al.  Evaluation of energy correction algorithm for signals of PET in heavy-ion cancer therapy device , 2020 .

[17]  R. Fontaine,et al.  Real Time Coincidence Detection Engine for High Count Rate Timestamp Based PET , 2010, IEEE Transactions on Nuclear Science.

[18]  Wolfgang Enghardt,et al.  In-beam PET at clinical proton beams with pile-up rejection. , 2017, Zeitschrift fur medizinische Physik.

[19]  Shubin Liu,et al.  A fully fledged TDC implemented in field-programmable-gate-arrays , 2009, 2009 16th IEEE-NPSS Real Time Conference.

[20]  G. Muehllehner,et al.  Time of flight coincidence timing calibration techniques using radioactive sources , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.