Frailty in elderly people

[1]  G. Langer,et al.  Nutritional interventions for preventing and treating pressure ulcers. , 2014, The Cochrane database of systematic reviews.

[2]  R. Gobbens,et al.  The predictive validity of the Tilburg Frailty Indicator: disability, health care utilization, and quality of life in a population at risk. , 2012, The Gerontologist.

[3]  Sarah E Lamb,et al.  Interventions for preventing falls in older people living in the community. , 2012, The Cochrane database of systematic reviews.

[4]  A. Mitnitski,et al.  Disability and co-morbidity in relation to frailty: how much do they overlap? , 2012, Archives of gerontology and geriatrics.

[5]  H. Boter,et al.  Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review , 2012, Journal of the American Geriatrics Society.

[6]  M. Catt,et al.  Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study , 2012, Mechanisms of Ageing and Development.

[7]  A. Bayer,et al.  The impact of frailty and delirium on mortality in older inpatients. , 2012, Age and ageing.

[8]  A. Newman,et al.  Decline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study. , 2012, The Journal of clinical endocrinology and metabolism.

[9]  M. Tinetti,et al.  Goal-oriented patient care--an alternative health outcomes paradigm. , 2012, The New England journal of medicine.

[10]  A. Forster,et al.  Do home-based exercise interventions improve outcomes for frail older people? Findings from a systematic review. , 2012, Reviews in clinical gerontology.

[11]  J. Staal,et al.  Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: A meta-analysis , 2012, Ageing Research Reviews.

[12]  T. Gill,et al.  Frailty and respiratory impairment in older persons. , 2012, The American journal of medicine.

[13]  Todd M Manini,et al.  Dynapenia and aging: an update. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  John B. Young,et al.  Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment? , 2012, Age and ageing.

[15]  Sathya Karunananthan,et al.  The Identification of Frailty: A Systematic Literature Review , 2011, Journal of the American Geriatrics Society.

[16]  Peter Langhorne,et al.  Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials , 2011, BMJ : British Medical Journal.

[17]  L. Fried,et al.  Measurement of Organ Structure and Function Enhances Understanding of the Physiological Basis of Frailty: The Cardiovascular Health Study , 2011, Journal of the American Geriatrics Society.

[18]  A. Mitnitski,et al.  Nontraditional risk factors combine to predict Alzheimer disease and dementia , 2011, BDJ.

[19]  L. Fried,et al.  Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. , 2011, Vaccine.

[20]  A. Silman,et al.  Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study , 2011, Journal of the American Geriatrics Society.

[21]  Anthony A. Vandervoort,et al.  The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review , 2011, Journal of aging research.

[22]  P. Abadir The frail renin-angiotensin system. , 2011, Clinics in geriatric medicine.

[23]  M.W.G. Nijhuis-van der Sanden,et al.  Outcome instruments to measure frailty: A systematic review , 2011, Ageing Research Reviews.

[24]  S. Studenski,et al.  Gait speed and survival in older adults. , 2011, JAMA.

[25]  G. B. Phillips Adverse events associated with testosterone administration. , 2010, The New England journal of medicine.

[26]  Paul Stolee,et al.  Examining three frailty conceptualizations in their ability to predict negative outcomes for home-care clients. , 2010, Age and ageing.

[27]  Marten Scheffer,et al.  Complex systems: Foreseeing tipping points , 2010, Nature.

[28]  Patrick O. McGowan,et al.  Environmental epigenomics: understanding the effects of parental care on the epigenome. , 2010, Essays in biochemistry.

[29]  L. Ferrucci,et al.  Does accumulation of advanced glycation end products contribute to the aging phenotype? , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[30]  François Béland,et al.  A correspondence analysis revealed frailty deficits aggregate and are multidimensional. , 2010, Journal of clinical epidemiology.

[31]  J. Baeyens,et al.  Sarcopenia: European consensus on definition and diagnosis , 2010, Age and ageing.

[32]  Thomas M Gill,et al.  Trajectories of disability in the last year of life. , 2010, The New England journal of medicine.

[33]  Kenneth Rockwood,et al.  Prevalence and 10‐Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation , 2010, Journal of the American Geriatrics Society.

[34]  L. D. de Witte,et al.  University of Groningen THE PSYCHOMETRIC PROPERTIES OF THREE SELF-REPORT SCREENING INSTRUMENTS FOR IDENTIFYING FRAIL OLDER PEOPLE IN THE COMMUNITY , 2017 .

[35]  B. Yankner,et al.  Neural mechanisms of ageing and cognitive decline , 2010, Nature.

[36]  Ronald A. DePinho,et al.  Linking functional decline of telomeres, mitochondria and stem cells during ageing , 2010, Nature.

[37]  P. Eikelenboom,et al.  Systemic infection and delirium: when cytokines and acetylcholine collide , 2010, The Lancet.

[38]  David A Bennett,et al.  Physical Frailty Is Associated with Incident Mild Cognitive Impairment in Community‐Based Older Persons , 2010, Journal of the American Geriatrics Society.

[39]  A. Meikle Sex Hormones and Frailty in Older Men: The Osteoporotic Fractures in Men (MrOS) Study , 2010 .

[40]  Jianqing Ding,et al.  Microglia in the aging brain: relevance to neurodegeneration , 2010, Molecular Neurodegeneration.

[41]  L. Ferrucci,et al.  Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[42]  A. Kenny,et al.  The association between dehydroepiandosterone and frailty in older men and women. , 2009, Age and ageing.

[43]  C. Szoeke,et al.  Pharmacological Treatment of Frailty in the Elderly , 2009 .

[44]  S. Leng,et al.  Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. , 2009, Cytokine.

[45]  Sathya Karunananthan,et al.  Role of frailty in patients with cardiovascular disease. , 2009, The American journal of cardiology.

[46]  J. Spagnoli,et al.  Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[47]  C. Blaum,et al.  Comparing Models of Frailty: The Health and Retirement Study , 2009, Journal of the American Geriatrics Society.

[48]  G. Savva,et al.  Inflammation and frailty measures in older people , 2009, Journal of cellular and molecular medicine.

[49]  C. Macintyre,et al.  Immunological responses to pneumococcal vaccine in frail older people. , 2009, Vaccine.

[50]  L. Ferrucci,et al.  Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14+ monocytes in frail older adults , 2009, Mechanisms of Ageing and Development.

[51]  M. Fraga,et al.  Epigenetics and aging: status, challenges, and needs for the future. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[52]  Anne Forster,et al.  Rehabilitation for older people in long-term care. , 2009, The Cochrane database of systematic reviews.

[53]  G. Elder,et al.  C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects. , 2008, Age and ageing.

[54]  H. van Praag,et al.  Exercise and the brain: something to chew on. , 2009, Trends in neurosciences.

[55]  Thomas M Gill,et al.  Prognostic Significance of Potential Frailty Criteria , 2008, Journal of the American Geriatrics Society.

[56]  T. Gill,et al.  A standard procedure for creating a frailty index , 2008, BMC geriatrics.

[57]  S. Espinoza,et al.  Frailty in Older Mexican‐American and European‐American Adults: Is There an Ethnic Disparity? , 2008, Journal of the American Geriatrics Society.

[58]  Christoph Handschin,et al.  The role of exercise and PGC1α in inflammation and chronic disease , 2008, Nature.

[59]  A. Berchtold,et al.  Dynamics of Frailty and ADL Dependence in a Five-Year Longitudinal Study of Octogenarians , 2008 .

[60]  Konstantin G Arbeev,et al.  Cumulative Deficits Better Characterize Susceptibility to Death in Elderly People than Phenotypic Frailty: Lessons from the Cardiovascular Health Study , 2008, Journal of the American Geriatrics Society.

[61]  Rachael Gooberman-Hill,et al.  Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis , 2008, The Lancet.

[62]  Brent C Taylor,et al.  Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. , 2008, Archives of internal medicine.

[63]  R. Varadhan,et al.  Higher levels and blunted diurnal variation of cortisol in frail older women. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[64]  C. Jankowski Oxidative protein damage is associated with poor grip strength among older women living in the community , 2008 .

[65]  M. Mcmurdo,et al.  Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial , 2007, Canadian Medical Association Journal.

[66]  B. Graubard,et al.  Insulin-like growth factors and subsequent risk of mortality in the United States. , 2007, American journal of epidemiology.

[67]  A. Mitnitski,et al.  A comparison of two approaches to measuring frailty in elderly people. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[68]  A. Mitnitski,et al.  Frailty in relation to the accumulation of deficits. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[69]  David A Bennett,et al.  Frailty is Associated With Incident Alzheimer’s Disease and Cognitive Decline in the Elderly , 2007, Psychosomatic medicine.

[70]  D. Knol,et al.  Vitamin D status predicts physical performance and its decline in older persons. , 2007, The Journal of clinical endocrinology and metabolism.

[71]  L. Fried,et al.  Inflammation and Frailty in Older Women , 2007, Journal of the American Geriatrics Society.

[72]  L. Fried,et al.  Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. , 2007, Archives of internal medicine.

[73]  F. Martin,et al.  Proactive care of older people undergoing surgery ('POPS'): designing, embedding, evaluating and funding a comprehensive geriatric assessment service for older elective surgical patients. , 2007, Age and ageing.

[74]  L. Ferrucci,et al.  DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[75]  W. Streit Microglial senescence: does the brain's immune system have an expiration date? , 2006, Trends in Neurosciences.

[76]  Ross T Tsuyuki,et al.  Validity and reliability of the Edmonton Frail Scale , 2006, Age and ageing.

[77]  S. Studenski,et al.  Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults , 2006, Journal of the American Geriatrics Society.

[78]  M. Visser,et al.  Inflammatory markers and loss of muscle mass (sarcopenia) and strength. , 2006, The American journal of medicine.

[79]  Kenneth Rockwood,et al.  Long‐Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70 , 2006, Journal of the American Geriatrics Society.

[80]  A. Mitnitski,et al.  Limits to deficit accumulation in elderly people , 2006, Mechanisms of Ageing and Development.

[81]  L. Ferrucci,et al.  Phenotype of frailty: characterization in the women's health and aging studies. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[82]  Thomas M Gill,et al.  Transitions between frailty states among community-living older persons. , 2006, Archives of internal medicine.

[83]  M. Gleeson,et al.  Exercise and Toll-like receptors. , 2006, Exercise immunology review.

[84]  A. Avenell,et al.  Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. , 2009, The Cochrane database of systematic reviews.

[85]  J. Cox,et al.  Relative Fitness and Frailty of Elderly Men and Women in Developed Countries and Their Relationship with Mortality , 2005, Journal of the American Geriatrics Society.

[86]  V. Perry,et al.  Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration , 2005, The Journal of Neuroscience.

[87]  V Demicheli,et al.  Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review , 2005, The Lancet.

[88]  D. Attaix,et al.  Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. , 2005, The international journal of biochemistry & cell biology.

[89]  M. Visser,et al.  Endocrine and inflammatory markers as predictors of frailty , 2005, Clinical endocrinology.

[90]  H. Cohen,et al.  Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). , 2005, Critical reviews in oncology/hematology.

[91]  Kenneth Rockwood,et al.  What would make a definition of frailty successful? , 2005, Age and ageing.

[92]  I. McDowell,et al.  A global clinical measure of fitness and frailty in elderly people , 2005, Canadian Medical Association Journal.

[93]  L. Ferrucci,et al.  Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and II. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[94]  J. O'Callaghan,et al.  Aging, stress and the hippocampus , 2005, Ageing Research Reviews.

[95]  K. Kinsella,et al.  Global aging : the challenge of success , 2005 .

[96]  T. Kirkwood,et al.  Understanding the Odd Science of Aging , 2005, Cell.

[97]  Kenneth Rockwood,et al.  Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[98]  Kenneth Rockwood,et al.  Operationalizing a Frailty Index from a Standardized Comprehensive Geriatric Assessment , 2004, Journal of the American Geriatrics Society.

[99]  K. Rockwood,et al.  Frailty and the geriatrician. , 2004, Age and ageing.

[100]  Siegwart Lindenberg,et al.  Old or frail: what tells us more? , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[101]  P. Panegyres The contribution of the study of neurodegenerative disorders to the understanding of human memory. , 2004, QJM : monthly journal of the Association of Physicians.

[102]  S. Leng,et al.  Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty , 2004, Aging clinical and experimental research.

[103]  L. Ferrucci,et al.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[104]  E. Barrett-Connor,et al.  The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. , 2004, The Journal of clinical endocrinology and metabolism.

[105]  C. Cooper,et al.  Is grip strength a useful single marker of frailty? , 2003, Age and ageing.

[106]  T. Harris,et al.  Insulin‐Like Growth Factor‐1 and Interleukin 6 Predict Sarcopenia in Very Old Community‐Living Men and Women: The Framingham Heart Study , 2003, Journal of the American Geriatrics Society.

[107]  L. Ferrucci,et al.  Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. , 2003, The Journal of clinical endocrinology and metabolism.

[108]  John P Hirdes,et al.  The MDS‐CHESS Scale: A New Measure to Predict Mortality in Institutionalized Older People , 2003, Journal of the American Geriatrics Society.

[109]  George E. Taffett Physiology of Aging , 2003 .

[110]  L. Fried,et al.  Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. , 2002, Archives of internal medicine.

[111]  S. Lamberts,et al.  The endocrinology of aging and the brain. , 2002, Archives of neurology.

[112]  H. Allore,et al.  A program to prevent functional decline in physically frail, elderly persons who live at home. , 2002, The New England journal of medicine.

[113]  J. Williamson,et al.  Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study , 2002, The Lancet.

[114]  L. Lipsitz Dynamics of stability: the physiologic basis of functional health and frailty. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[115]  Matthias Egger,et al.  Home visits to prevent nursing home admission and functional decline in elderly people: systematic review and meta-regression analysis. , 2002, JAMA.

[116]  S. Bandinelli,et al.  Biomarkers of frailty in older persons. , 2002, Journal of endocrinological investigation.

[117]  L. Fried,et al.  Weight Change in Old Age and its Association with Mortality , 2001, Journal of the American Geriatrics Society.

[118]  Kenneth Rockwood,et al.  Accumulation of Deficits as a Proxy Measure of Aging , 2001, TheScientificWorldJournal.

[119]  J. Yesavage,et al.  One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women. , 2001, The Journal of clinical endocrinology and metabolism.

[120]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[121]  H. Payette,et al.  Nutrition risk factors for institutionalization in a free-living functionally dependent elderly population. , 2000, Journal of clinical epidemiology.

[122]  S. Shah,et al.  The Frail Elderly Functional Assessment questionnaire: its responsiveness and validity in alternative settings. , 1999, Archives of physical medicine and rehabilitation.

[123]  H. Cohen,et al.  Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. , 1999, The American journal of medicine.

[124]  J. Kehayias,et al.  Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. , 1999, The American journal of physiology.

[125]  D M Buchner,et al.  Unstable disability and the fluctuations of frailty. , 1997, Age and ageing.

[126]  K. Swedberg,et al.  Skeletal muscle changes in patients with chronic heart failure before and after treatment with enalapril. , 1996, European heart journal.

[127]  Richard A. Miller The Aging Immune System: Primer and Prospectus , 1996, Science.

[128]  J. Walston,et al.  RELIABILITY AND VALIDITY OF THE FRAIL ELDERLY FUNCTIONAL ASSESSMENT QUESTIONNAIRE , 1995, American journal of physical medicine & rehabilitation.

[129]  A. Goldberg,et al.  Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[130]  S B Roberts,et al.  Exercise training and nutritional supplementation for physical frailty in very elderly people. , 1994, The New England journal of medicine.

[131]  L. Moldawer,et al.  Cachexia and the acute‐phase protein response in inflammation are regulated by interleukin‐6 , 1993, European journal of immunology.

[132]  L. Rubenstein,et al.  Impacts of Geriatric Evaluation and Management Programs on Defined Outcomes: Overview of the Evidence , 1991, Journal of the American Geriatrics Society.

[133]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.

[134]  Diane Podsiadlo,et al.  The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons , 1991, Journal of the American Geriatrics Society.

[135]  J. Florini,et al.  Hormones, growth factors, and myogenic differentiation. , 1991, Annual review of physiology.

[136]  R. Walls,et al.  Impact of nutrition status on morbidity and mortality in a select population of geriatric rehabilitation patients. , 1990, The American journal of clinical nutrition.

[137]  J. Morley,et al.  Endocrinology in aging. , 1988, Disease-a-month : DM.

[138]  C. Gryfe,et al.  Physiology of Aging , 1986 .

[139]  L. Radloff The CES-D Scale , 1977 .