Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells.

[1]  G. Berchem,et al.  The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model , 2018, Haematologica.

[2]  Sudharsana Rao Ande,et al.  Prohibitin: a potential therapeutic target in tyrosine kinase signaling , 2017, Signal Transduction and Targeted Therapy.

[3]  P. Sarma,et al.  PHB in Cardiovascular and Other Diseases: Present Knowledge and Implications. , 2017, Current drug targets.

[4]  L. Penalva,et al.  MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1 , 2017, BMC Cancer.

[5]  E. González-Barca,et al.  The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax , 2017, Haematologica.

[6]  T. Pulinilkunnil,et al.  The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation , 2017, Molecular Cancer Research.

[7]  D. Bonatto,et al.  Accumulation of prohibitin is a common cellular response to different stressing stimuli and protects melanoma cells from ER stress and chemotherapy-induced cell death , 2017, Oncotarget.

[8]  K. David,et al.  Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours , 2017, Oncogene.

[9]  N. Doudican,et al.  Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib , 2017, Oncogene.

[10]  Prashant Mishra,et al.  Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor , 2017, Cell.

[11]  E. González-Barca,et al.  Targeting prohibitins induces apoptosis in acute myeloid leukemia cells , 2016, Oncotarget.

[12]  Shuai Zhao,et al.  Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer , 2016, Journal of experimental & clinical cancer research : CR.

[13]  Eun-Young Kim,et al.  Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes , 2016, Scientific Reports.

[14]  L. Désaubry,et al.  Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction , 2016, Inflammatory bowel diseases.

[15]  W. Jiang,et al.  Unveiling the potential of prohibitin in cancer. , 2015, Cancer letters.

[16]  Tan Lu,et al.  Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling , 2015, Molecules and cells.

[17]  L. Désaubry,et al.  FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity , 2015, PloS one.

[18]  T. Langer,et al.  A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation , 2015, Oncotarget.

[19]  R. Ouyang,et al.  Multifaceted role of prohibitin in cell survival and apoptosis , 2015, Apoptosis.

[20]  J. Hoenderop,et al.  Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity , 2015, PloS one.

[21]  Duncan R. Smith,et al.  Assessment of flavaglines as potential chikungunya virus entry inhibitors , 2015, Microbiology and immunology.

[22]  F. Zhou,et al.  Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells , 2015, Cell Death and Disease.

[23]  S. Liang,et al.  MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis , 2014, Oncotarget.

[24]  H. Handa,et al.  A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins. , 2014, Angewandte Chemie.

[25]  A. Eggermont,et al.  eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies , 2014, Nature.

[26]  G. Ghanem,et al.  Prominent role of cyclic adenosine monophosphate signalling pathway in the sensitivity of (WT)BRAF/(WT)NRAS melanoma cells to vemurafenib. , 2014, European journal of cancer.

[27]  J. Eluf-Neto,et al.  Polymorphisms in the p27kip-1 and prohibitin genes denote novel genes associated with melanoma risk in Brazil, a high ultraviolet index region , 2013, Melanoma research.

[28]  Xin Zhang,et al.  A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas , 2013, Diagnostic Pathology.

[29]  N. Ribeiro,et al.  Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential , 2013, Chemistry & Biology.

[30]  M. Leippe,et al.  The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. , 2012, Chemistry & biology.

[31]  M. Uesugi,et al.  Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. , 2011, Chemistry & biology.

[32]  S. Baek,et al.  Chemical affinity matrix-based identification of prohibitin as a binding protein to anti-resorptive sulfonyl amidine compounds. , 2011, Bioorganic & medicinal chemistry letters.

[33]  S. Filetti,et al.  Prohibitin is overexpressed in papillary thyroid carcinomas bearing the BRAF(V600E) mutation. , 2009, Thyroid : official journal of the American Thyroid Association.

[34]  S. Kang,et al.  Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways , 2008, Oncogene.

[35]  Ting-feng Wu,et al.  Prohibitin in the pathogenesis of transitional cell bladder cancer. , 2007, Anticancer research.

[36]  T. Rudel,et al.  Ras-Raf Signaling Needs Prohibitin , 2005, Cell cycle.

[37]  Volker Brinkmann,et al.  Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration , 2005, Nature Cell Biology.

[38]  Young-Tae Chang,et al.  Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. , 2005, Chemistry & biology.

[39]  Tae-Wook Kang,et al.  Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening. , 2003, Journal of the American Chemical Society.

[40]  J. Padmanabhan,et al.  Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression , 2002, Oncogene.

[41]  M. Khaled,et al.  Glycogen Synthase Kinase 3β Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis* , 2002, The Journal of Biological Chemistry.

[42]  S. Chellappan,et al.  Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis , 2002, Oncogene.

[43]  D. Faller,et al.  Prohibitin requires Brg‐1 and Brm for the repression of E2F and cell growth , 2002, The EMBO journal.

[44]  E. Price,et al.  c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. , 2000, Genes & development.

[45]  Niharika Nath,et al.  Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals , 1999, Molecular and Cellular Biology.

[46]  N. Nath,et al.  Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function , 1999, Oncogene.

[47]  E. Seto,et al.  Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites. , 2007, The Biochemical journal.