ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

[1]  R. Elkon,et al.  The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration , 2023, PLoS biology.

[2]  M. Fontana,et al.  Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine , 2021, International journal of molecular sciences.

[3]  T. Paull,et al.  Cellular functions of the protein kinase ATM and their relevance to human disease , 2021, Nature Reviews Molecular Cell Biology.

[4]  N. Shomron,et al.  Slow transcription of the 99a/let-7c/125b-2 cluster results in differential miRNA expression and promotes melanoma phenotypic plasticity. , 2021, The Journal of investigative dermatology.

[5]  L. Montoliu,et al.  Genetics of non‐syndromic and syndromic oculocutaneous albinism in human and mouse , 2021, Pigment cell & melanoma research.

[6]  Javad Zahiri,et al.  Post-translational modifications in proteins: resources, tools and prediction methods , 2021, Database J. Biol. Databases Curation.

[7]  G. Juhász,et al.  Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress , 2020, Redox biology.

[8]  Tamio Suzuki,et al.  Current landscape of Oculocutaneous Albinism in Japan , 2020, Pigment cell & melanoma research.

[9]  M. Antal,et al.  PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes—Implications for UV-Induced DNA Repair and Photocarcinogenesis , 2019, Cancers.

[10]  D. Brash,et al.  Genomic sites hypersensitive to ultraviolet radiation , 2019, Proceedings of the National Academy of Sciences.

[11]  Eui-Hwan Choi,et al.  E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors , 2019, Experimental & Molecular Medicine.

[12]  T. Soga,et al.  MITF controls the TCA cycle to modulate the melanoma hypoxia response , 2019, Pigment cell & melanoma research.

[13]  Nicola D. Roberts,et al.  BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma , 2019, Genes & development.

[14]  Carmit Levy,et al.  Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling , 2019, International journal of molecular sciences.

[15]  A. Barzilai,et al.  Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype. , 2018, DNA repair.

[16]  S. Shen-Orr,et al.  UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems , 2018, Molecular cell.

[17]  Mauro A. A. Castro,et al.  The chromatin accessibility landscape of primary human cancers , 2018, Science.

[18]  S. Knapp,et al.  BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export , 2018, Proceedings of the National Academy of Sciences.

[19]  So Min Kim,et al.  Repigmentation in a Vitiligo Universalis Patient: Chemotherapy-Induced or Spontaneous? , 2017, Annals of dermatology.

[20]  J. Hanna,et al.  OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs , 2017, Nature Communications.

[21]  Yang Shi,et al.  m6A RNA methylation regulates the UV-induced DNA damage response , 2016, Nature.

[22]  Philip R. Cohen.  Paclitaxel-associated reticulate hyperpigmentation: Report and review of chemotherapy-induced reticulate hyperpigmentation , 2016, World journal of clinical cases.

[23]  T. Crawford,et al.  Ataxia telangiectasia: a review , 2016, Orphanet Journal of Rare Diseases.

[24]  T. Kipps,et al.  ATM Mutations in Cancer: Therapeutic Implications , 2016, Molecular Cancer Therapeutics.

[25]  Asha A. Nair,et al.  Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins. , 2016, Cell reports.

[26]  P. Cole,et al.  Synthetic approaches to protein phosphorylation. , 2015, Current opinion in chemical biology.

[27]  D. Sprinzak,et al.  Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. , 2015, Molecular cell.

[28]  M. Martinka,et al.  Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma , 2015, PloS one.

[29]  Marko Hočevar,et al.  Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma , 2015, Nature Genetics.

[30]  R. Halaban,et al.  Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure , 2015, Science.

[31]  Roland Zengerle,et al.  Analysis of fast protein phosphorylation kinetics in single cells on a microfluidic chip. , 2015, Lab on a chip.

[32]  Björn Titz,et al.  MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells , 2015, Proceedings of the National Academy of Sciences.

[33]  A. Behrens,et al.  ATM signalling and cancer , 2014, Oncogene.

[34]  Alexander A. Alemi,et al.  Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma , 2014, PloS one.

[35]  T. Ikejima,et al.  Silibinin protects murine fibroblast L929 cells from UVB‐induced apoptosis through the simultaneous inhibition of ATM‐p53 pathway and autophagy , 2013, The FEBS journal.

[36]  M. Löbrich,et al.  ATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination , 2013, PLoS genetics.

[37]  S. Greenberger,et al.  Dermatologic manifestations of ataxia-telangiectasia syndrome. , 2013, Journal of the American Academy of Dermatology.

[38]  Y. Shiloh,et al.  The ATM protein kinase: regulating the cellular response to genotoxic stress, and more , 2013, Nature Reviews Molecular Cell Biology.

[39]  Baoyan Bai,et al.  Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM , 2013, PloS one.

[40]  S. Thiyagarajan,et al.  MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. , 2013, The Journal of investigative dermatology.

[41]  N. Bowden,et al.  The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis , 2013, International journal of molecular sciences.

[42]  Majd Alfreijat.  Tongue hyperpigmentation associated with chemotherapy , 2013, Journal of community hospital internal medicine perspectives.

[43]  Hee‐Young Park,et al.  Tyrosinase: a central regulatory protein for cutaneous pigmentation. , 2012, The Journal of investigative dermatology.

[44]  G. Oakley,et al.  Deficient DNA Damage Signaling Leads to Chemoresistance to Cisplatin in Oral Cancer , 2012, Molecular Cancer Therapeutics.

[45]  K. Brown,et al.  Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ Light Chain Enhancer of Activated B Cells (NFκB) Signaling Controls Basal and DNA Damage-induced Transglutaminase 2 Expression* , 2012, The Journal of Biological Chemistry.

[46]  Seon-Hee Oh,et al.  Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. , 2012, Biochemical pharmacology.

[47]  K. Brown,et al.  A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma , 2011, Nature.

[48]  Libing Song,et al.  miR-18a Impairs DNA Damage Response through Downregulation of Ataxia Telangiectasia Mutated (ATM) Kinase , 2011, PloS one.

[49]  N. Saba,et al.  Images in clinical medicine. Chemotherapy-induced hyperpigmentation of the tongue. , 2011, The New England journal of medicine.

[50]  Laurent Beuret,et al.  BRCA1 is a new MITF target gene , 2011, Pigment Cell & Melanoma Research.

[51]  C. Bertolotto,et al.  Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma , 2011, Oncogene.

[52]  T. M. Rünger,et al.  No formation of DNA double-strand breaks and no activation of recombination repair with UVA. , 2011, The Journal of investigative dermatology.

[53]  Jie Chen,et al.  E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks , 2011, Cell cycle.

[54]  Jun S. Song,et al.  Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. , 2010, Molecular cell.

[55]  David J. Chen,et al.  ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage , 2010, Science Signaling.

[56]  K. Hoek,et al.  Cancer stem cells versus phenotype‐switching in melanoma , 2010, Pigment cell & melanoma research.

[57]  Jun S. Song,et al.  Lineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes , 2010, Cell.

[58]  O. Toussaint,et al.  Proteomic Profiling of Human Keratinocytes Undergoing UVB-Induced Alternative Differentiation Reveals TRIpartite Motif Protein 29 as a Survival Factor , 2010, PloS one.

[59]  Jie Chen,et al.  E2F1 Localizes to Sites of UV-induced DNA Damage to Enhance Nucleotide Excision Repair* , 2010, The Journal of Biological Chemistry.

[60]  Z. Darżynkiewicz,et al.  Kinetics of the UV‐induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication , 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[61]  K. Wakamatsu,et al.  Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice , 2009, Pigment cell & melanoma research.

[62]  K. Valerie,et al.  Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion , 2009, Molecular Cancer Therapeutics.

[63]  D. Jukic,et al.  Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation , 2009, Cancer biology & therapy.

[64]  K. Wakamatsu,et al.  Short- and long-term effects of UV radiation on the pigmentation of human skin. , 2009, The journal of investigative dermatology. Symposium proceedings.

[65]  T. Heffernan,et al.  ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. , 2009, The Journal of investigative dermatology.

[66]  J. Munoz-Munoz,et al.  Generation of hydrogen peroxide in the melanin biosynthesis pathway. , 2009, Biochimica et biophysica acta.

[67]  T. Hei,et al.  Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. , 2009, Cancer research.

[68]  B. Kaina,et al.  How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. , 2009, Mutation research.

[69]  S. Kozubek,et al.  Chromatin structure influences the sensitivity of DNA to gamma-radiation. , 2008, Biochimica et biophysica acta.

[70]  H. Krokan,et al.  The rate of base excision repair of uracil is controlled by the initiating glycosylase. , 2008, DNA repair.

[71]  S. Bojesen,et al.  Risk of cancer by ATM missense mutations in the general population. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[72]  David E. Fisher,et al.  Central Role of p53 in the Suntan Response and Pathologic Hyperpigmentation , 2007, Cell.

[73]  D. Fisher,et al.  Melanocyte biology and skin pigmentation , 2007, Nature.

[74]  M. Ramoni,et al.  Expression profiling of UVB response in melanocytes identifies a set of p53-target genes. , 2006, The Journal of investigative dermatology.

[75]  D. Alexandrescu,et al.  Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma. , 2006, Dermatology online journal.

[76]  D. Fisher,et al.  Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning , 2006, Nature.

[77]  Y. Shiloh,et al.  Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway , 2006, Nature Cell Biology.

[78]  J. Lieberman,et al.  A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery , 2006, Nature.

[79]  T. Golub,et al.  Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.

[80]  A. Yasui,et al.  The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. , 2005, DNA repair.

[81]  T. R. Berton,et al.  Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation , 2005, Oncogene.

[82]  L. Larue,et al.  Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression , 2005, Nature.

[83]  R. Delston,et al.  MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A , 2005, The Journal of cell biology.

[84]  Shosuke Ito,et al.  Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[85]  D. Fisher,et al.  Transcriptional Regulation of the Melanoma Prognostic Marker Melastatin (TRPM1) by MITF in Melanocytes and Melanoma , 2004, Cancer Research.

[86]  Carmit Levy,et al.  Role Played by Microphthalmia Transcription Factor Phosphorylation and Its Zip Domain in Its Transcriptional Inhibition by PIAS3 , 2003, Molecular and Cellular Biology.

[87]  Jeffrey D Laskin,et al.  UVB Light Stimulates Production of Reactive Oxygen Species , 2003, Journal of Biological Chemistry.

[88]  M. Kastan,et al.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.

[89]  Michael C. Ostrowski,et al.  Microphthalmia Transcription Factor Is a Target of the p38 MAPK Pathway in Response to Receptor Activator of NF-κB Ligand Signaling* , 2002, The Journal of Biological Chemistry.

[90]  H. Muller,et al.  Ultraviolet light induced injury: Immunological and inflammatory effects , 2001, Immunology and cell biology.

[91]  G. Ghanem,et al.  Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor. , 2001, The Journal of investigative dermatology.

[92]  S. Nakajima,et al.  Cyclobutane Pyrimidine Dimers Are Responsible for the Vast Majority of Mutations Induced by UVB Irradiation in Mammalian Cells* , 2001, The Journal of Biological Chemistry.

[93]  M. J. Moné,et al.  Local UV‐induced DNA damage in cell nuclei results in local transcription inhibition , 2001, EMBO reports.

[94]  M. Barton,et al.  UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[95]  A. Yasui,et al.  The DNA damage spectrum produced by simulated sunlight. , 2000, Journal of molecular biology.

[96]  E. Price,et al.  c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. , 2000, Genes & development.

[97]  W. Sessa,et al.  Regulation of endothelium-derived nitric oxide production by the protein kinase Akt , 1999, Nature.

[98]  Y Taya,et al.  A role for ATR in the DNA damage-induced phosphorylation of p53. , 1999, Genes & development.

[99]  Y Taya,et al.  Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.

[100]  S. Bhattacharya,et al.  Lineage-specific Signaling in Melanocytes , 1998, The Journal of Biological Chemistry.

[101]  R. Drouin,et al.  UVB‐induced Cyclobutane Pyrimidine Dimer Frequency Correlates with Skin Cancer Mutational Hotspots in p53 , 1997, Photochemistry and photobiology.

[102]  B. Gilchrest,et al.  DNA damage enhances melanogenesis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[103]  H. Schulman,et al.  Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies. , 1990, Biochemistry.

[104]  A. Pokora,et al.  Photodestruction of pheomelanin: role of oxygen. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[105]  V. Hearing,et al.  Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis. , 2009, The Journal of investigative dermatology.

[106]  B. Gilchrest,et al.  Tyrosinase gene expression is regulated by p53. , 2002, The Journal of investigative dermatology.

[107]  D. Fisher,et al.  Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. , 2000, Human molecular genetics.

[108]  Y Taya,et al.  Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.