Visual Perception Based Assistance for Fundus Image

Diabetic Retinopathy (DR) is a condition where individuals with diabetes develop a disease in the inner wall of eye known as retina. DR is a major cause of visual impairments and early detection can prevent vision loss. Use of automatic systems for DR diagnosis is limited due to their lower accuracy. As an alternative, reading-centers are becoming popular in real-world scenarios. Reading center is a facility where retinal images coming from various sources are stored and trained personals(who might not be experts) analyze them. In this thesis we look at techniques to increase efficiency of DR image-readers working in reading centers. The first half of this thesis aims at identifying efficient image-reading technique which is both fast and accurate. Towards this end we have conducted an eye-tracking study with medical experts while they were reading images for DR diagnosis. The analysis shows that experts employ mainly two types of reading strategies: dwelling and tracing. Dwelling strategy appears to be accurate and faster than tracing strategy. Eye movements of all the experts are combined in a novel way to extract an optimal image scanning strategy, which can be recommended to image-readers for efficient diagnosis. In order to increase the efficiency further, we propose a technique where saliency of lesions can be boosted for better visibility of lesions. This is named as an Assistive Lesion Emphasis System(ALES) and demonstrated in the second half of the thesis. ALES is developed as a two stage system: saliency detection and lesion emphasis. Two biologically inspired saliency models, which mimic human visual system, are designed using unsupervised and supervised techniques. Unsupervised saliency model is inspired from human visual system and achieved 10% higher recall than other existing saliency models when compared with average gazemap of 15 retinal experts. Supervised saliency model developed as deep learning based implementation of biologically inspired saliency model proposed by IttiKoch(Itti, L., Koch, C. and Niebur, E., 1998) and achieves 10% to 20% higher AUC compared