AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes

[1]  R. Liu-Bryan,et al.  Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice. , 2021, Osteoarthritis and cartilage.

[2]  R. Liu-Bryan,et al.  Metformin limits osteoarthritis development and progression through activation of AMPK signalling , 2020, Annals of the Rheumatic Diseases.

[3]  Di Chen,et al.  Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression , 2020, International journal of biological sciences.

[4]  G. Xiao,et al.  Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR , 2020, Aging.

[5]  S. Indraccolo,et al.  LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective , 2019, Oxidative medicine and cellular longevity.

[6]  E. Rozengurt,et al.  Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells. , 2019, The international journal of biochemistry & cell biology.

[7]  Qing Jiang,et al.  Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth‐plate abnormalities and promotes enchondroma‐like formation , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  Di Chen,et al.  Activation of β‐catenin in Col2‐expressing chondrocytes leads to osteoarthritis‐like defects in hip joint , 2019, Journal of cellular physiology.

[9]  S. Kee,et al.  Metformin-activated AMPK regulates β-catenin to reduce cell proliferation in colon carcinoma RKO cells , 2019, Oncology letters.

[10]  Takla Griss,et al.  The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting , 2018, EMBO molecular medicine.

[11]  Di Chen,et al.  Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects , 2018, International Journal of Oral Science.

[12]  Di Chen,et al.  Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice , 2017, Scientific Reports.

[13]  Di Chen,et al.  Osteoarthritis: toward a comprehensive understanding of pathological mechanism , 2017, Bone Research.

[14]  F. Luyten,et al.  Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis. , 2015, Osteoarthritis and cartilage.

[15]  B. Viollet,et al.  Metformin: from mechanisms of action to therapies. , 2014, Cell metabolism.

[16]  H. Im,et al.  MMP13 is a critical target gene during the progression of osteoarthritis , 2013, Arthritis Research & Therapy.

[17]  E. Schwarz,et al.  Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. , 2012, Arthritis and rheumatism.

[18]  J. B. Kim,et al.  Berberine suppresses proinflammatory responses through AMPK activation in macrophages. , 2009, American journal of physiology. Endocrinology and metabolism.

[19]  R. O’Keefe,et al.  Activation of β‐Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis‐Like Phenotype in Adult β‐Catenin Conditional Activation Mice , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  Francis Berenbaum,et al.  Primary culture and phenotyping of murine chondrocytes , 2008, Nature Protocols.

[21]  N. Lane,et al.  FRZB: a bone and joint connection. , 2007, Arthritis and rheumatism.

[22]  J. Schrooten,et al.  Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. , 2007, Arthritis and rheumatism.

[23]  D. James,et al.  Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States , 2006, Diabetes.

[24]  M. Nevitt,et al.  Frizzled-related protein variants are risk factors for hip osteoarthritis. , 2006, Arthritis and rheumatism.

[25]  J. Loughlin The genetic epidemiology of human primary osteoarthritis: current status , 2005, Expert Reviews in Molecular Medicine.

[26]  J. Houwing-Duistermaat,et al.  Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. , 2005, Arthritis and rheumatism.