In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model.
暂无分享,去创建一个
Sven Frokjaer | Birger Brodin | S. Frokjaer | B. Brodin | C. Nielsen | Silvina A Bravo | J. Amstrup | Carsten Uhd Nielsen | Jan Amstrup
[1] V. Ganapathy,et al. Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP. , 1996, Biochemical and biophysical research communications.
[2] I. Alferiev,et al. A peptide prodrug approach for improving bisphosphonate oral absorption. , 2000, Journal of medicinal chemistry.
[3] B. Rothen‐Rutishauser,et al. Formation of Multilayers in the Caco-2 Cell Culture Model: A Confocal Laser Scanning Microscopy Study , 2000, Pharmaceutical Research.
[4] M. Hediger,et al. Differential Recognition of ACE Inhibitors in Xenopus Laevis Oocytes Expressing Rat PEPT1 and PEPT2 , 2000, Pharmaceutical Research.
[5] C. Tse,et al. Nucleoside transport in human colonic epithelial cell lines: evidence for two Na+-independent transport systems in T84 and Caco-2 cells. , 1999, Biochimica et biophysica acta.
[6] T. Tsuruo,et al. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. , 1993, The Journal of biological chemistry.
[7] A. Blais,et al. Common characteristics for Na+-dependent sugar transport in Caco-2 cells and human fetal colon , 2005, The Journal of Membrane Biology.
[8] S. Frokjaer,et al. Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line. , 2001, Journal of controlled release : official journal of the Controlled Release Society.
[9] V. Ganapathy,et al. Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. , 1998, Biochemical and biophysical research communications.
[10] G. Amidon,et al. Intestinal absorption mechanism of dipeptide angiotensin converting enzyme inhibitors of the lysyl-proline type: lisinopril and SQ 29,852. , 1989, Journal of pharmaceutical sciences.
[11] G. Amidon,et al. Cellular Uptake Mechanism of Amino Acid Ester Prodrugs in Caco-2/hPEPT1 Cells Overexpressing a Human Peptide Transporter , 1998, Pharmaceutical Research.
[12] Hongshi Yu,et al. Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages , 1997, Pharmaceutical Research.
[13] Keisuke Konishi,et al. New and better protocols for a short-term Caco-2 cell culture system. , 2002, Journal of pharmaceutical sciences.
[14] H. Saito,et al. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. , 1993, The American journal of physiology.
[15] S. Frokjaer,et al. Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[16] J. Beaulieu,et al. Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line. , 1992, Gastroenterology.
[17] É. Brot-Laroche,et al. Expression and localization of GLUT-5 in Caco-2 cells, human small intestine, and colon. , 1992, The American journal of physiology.
[18] J. Moberly,et al. Transepithelial transport of cholyltaurine by Caco-2 cell monolayers is sodium dependent. , 1993, American Journal of Physiology.
[19] V. Ganapathy,et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. , 2000, Journal of pharmaceutical sciences.
[20] S. Frokjaer,et al. Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells. , 2003, Acta physiologica Scandinavica.
[21] W. Kramer,et al. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics. , 1990, Biochimica et biophysica acta.
[22] S. Adibi,et al. Characterization of an oligopeptide transporter in renal lysosomes. , 2000, Biochimica et biophysica acta.
[23] D. Thwaites,et al. Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco‐2): identification of substrates that undergo H+‐coupled absorption , 1994, British journal of pharmacology.
[24] J. Finley,et al. The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[25] A. Guo,et al. Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. , 1998, Biochemical and biophysical research communications.
[26] D. Thwaites,et al. Na(+)-independent, H(+)-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers. , 1993, The Journal of biological chemistry.
[27] R Hori,et al. H+ coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes. , 1992, The Journal of pharmacology and experimental therapeutics.
[28] F. Hirche,et al. Decisive structural determinants for the interaction of proline derivatives with the intestinal H+/peptide symporter. , 1999, European journal of biochemistry.
[29] R. Neubert,et al. Intestinal Transport of β-Lactam Antibiotics: Analysis of the Affinity at the H+/Peptide Symporter (PEPT1), the Uptake into Caco-2 Cell Monolayers and the Transepithelial Flux , 2004, Pharmaceutical Research.
[30] H. Saito,et al. Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2. , 1999, American journal of physiology. Gastrointestinal and liver physiology.
[31] B. H. Stewart,et al. Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes. , 1996, Journal of pharmaceutical sciences.
[32] I. Hidalgo,et al. Transport of bile acids in a human intestinal epithelial cell line, Caco-2. , 1990, Biochimica et biophysica acta.
[33] H. Saito,et al. Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes. , 1992, The Journal of pharmacology and experimental therapeutics.
[34] S. Adibi,et al. Hormonal regulation of oligopeptide transporter Pept-1 in a human intestinal cell line. , 1999, American journal of physiology. Cell physiology.
[35] S. Frokjaer,et al. Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[36] Thomas J. Raub,et al. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. , 1989, Gastroenterology.
[37] G. Amidon,et al. Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and Fosinopril , 1989, Pharmaceutical Research.
[38] H. Takeda,et al. Effect of Lipopolysaccharide on Peptide Transporter 1 Expression in Rat Small Intestine and Its Attenuation by Dexamethasone , 2002, Digestion.
[39] V Ganapathy,et al. Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. , 1998, Journal of pharmaceutical sciences.
[40] Claude Roques,et al. Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line , 1998, Pharmaceutical Research.
[41] M. Hediger,et al. Human Intestinal H+/Peptide Cotransporter , 1995, The Journal of Biological Chemistry.
[42] J. Polli,et al. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. , 2000, International journal of pharmaceutics.
[43] T. Kissel,et al. Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo Data , 1995, Pharmaceutical Research.