Intrathecal Gadolinium Use for the Chronic Pain Physician

The approach to intrathecal (IT) drug delivery malfunction is complicated, particularly for iodine‐allergic patients. In these situations, the current literature has not addressed the use of IT gadolinium. Case reports exist showing severe neurotoxic manifestations with IT gadolinium use. We sought to provide a resource for chronic pain physicians treating an iodine‐allergic patient and considering the use of IT gadolinium.

[1]  D. Provenzano,et al.  Fatal gadolinium-induced encephalopathy following accidental intrathecal administration: a case report and a comprehensive evidence-based review , 2019, Regional Anesthesia & Pain Medicine.

[2]  A. Popescu,et al.  Fact Finders for Patient Safety: Are Gadolinium-Based Contrast Media Safe Alternatives to Iodinated Contrast Agents for the Safe Performance of Spinal Injection Procedures? , 2018, Pain medicine.

[3]  N. Kocer,et al.  Intrathecal gadolinium-enhanced MR cisternography in patients with otorhinorrhea: 10-year experience of a tertiary referral center , 2018, Neuroradiology.

[4]  Fernando Calamante,et al.  Gadolinium deposition in the brain: summary of evidence and recommendations , 2017, The Lancet Neurology.

[5]  M. Saulino,et al.  The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines , 2017, Neuromodulation : journal of the International Neuromodulation Society.

[6]  D. Padalia,et al.  Intrathecal Injection of Gadobutrol: A Tale of Caution , 2017, Journal of pain & palliative care pharmacotherapy.

[7]  M. Saulino,et al.  The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines , 2017, Neuromodulation : journal of the International Neuromodulation Society.

[8]  M. Stelzner,et al.  Misconnections in the Critically Ill: Injection of High-Dose Gadolinium into an External Ventricular Drain. , 2016, A & A case reports.

[9]  K. Thamburaj,et al.  Magnetic Resonance Characteristics and Susceptibility Weighted Imaging of the Brain in Gadolinium Encephalopathy , 2015, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[10]  T. Thongngarm,et al.  Adverse reactions to iodinated contrast media: prevalence, risk factors and outcome-the results of a 3-year period. , 2013, Asian Pacific journal of allergy and immunology.

[11]  S. El-Saden,et al.  Complex imaging features of accidental cerebral intraventricular gadolinium administration. , 2013, Journal of neurosurgery.

[12]  B. Turkbey,et al.  Intrathecal Gadolinium-Enhanced MR Cisternography: A Comprehensive Review , 2013, American Journal of Neuroradiology.

[13]  M. Dighe,et al.  Allergic reactions to iodinated contrast media: premedication considerations for patients at risk , 2013, Emergency Radiology.

[14]  S. Mukherji,et al.  Imaging Evaluation of Intrathecal Baclofen Pump-Catheter Systems , 2011, American Journal of Neuroradiology.

[15]  O. Algın,et al.  Phase-contrast MRI and 3D-CISS versus contrast-enhanced MR cisternography for the detection of spontaneous third ventriculostomy. , 2011, Journal of neuroradiology. Journal de neuroradiologie.

[16]  Jiabin Liu,et al.  Gadolinium encephalopathy after intrathecal gadolinium injection. , 2010, Pain physician.

[17]  Sun-Chul Hwang,et al.  Neurotoxic Manifestations of an Overdose Intrathecal Injection of Gadopentetate Dimeglumine , 2010, Journal of Korean medical science.

[18]  C. Islak,et al.  Intrathecal Gadolinium-Enhanced MR Cisternography in the Evaluation of CSF Leakage , 2010, American Journal of Neuroradiology.

[19]  O. Algın,et al.  Phase-contrast MRI and 3D-CISS versus contrast-enhanced MR cisternography on the evaluation of the aqueductal stenosis , 2010, Neuroradiology.

[20]  J. Zhao,et al.  Overdosage of intrathecal gadolinium and neurological response. , 2008, Clinical radiology.

[21]  A. Sencer,et al.  LOCALIZATION OF CEREBROSPINAL FLUID LEAKS BY GADOLINIUM‐ENHANCED MAGNETIC RESONANCE CISTERNOGRAPHY: A 5‐YEAR SINGLE‐CENTER EXPERIENCE , 2008, Neurosurgery.

[22]  N. Kocer,et al.  Gadolinium-Enhanced MR Cisternography to Evaluate Dural Leaks in Intracranial Hypotension Syndrome , 2008, American Journal of Neuroradiology.

[23]  G. Goel,et al.  Intrathecal gadolinium-enhanced magnetic resonance cisternography in cerebrospinal fluid rhinorrhea: road ahead? , 2007, Journal of neurotrauma.

[24]  A. Muñoz,et al.  Cisternography and ventriculography gadopentate dimeglumine-enhanced MR imaging in pediatric patients: preliminary report. , 2007, AJNR. American journal of neuroradiology.

[25]  S. Arlt,et al.  Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine , 2007, Journal of Neurology.

[26]  E. von Elm,et al.  Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review , 2006, BMJ : British Medical Journal.

[27]  N. Ercan,et al.  Intrathecal gadolinium (gadopentetate dimeglumine)—enhanced MR cisternography used to determine potential communication between the cerebrospinal fluid pathways and intracranial arachnoid cysts , 2004, Neuroradiology.

[28]  A. Mironov,et al.  Intrathecal Gadolinium (Gadopentetate Dimeglumine) Enhanced Magnetic Resonance Myelography and Cisternography: Results of a Multicenter Study , 2002, Investigative radiology.

[29]  J. Jinkins,et al.  Intrathecal gadolinium-enhanced MR cisternography in the evaluation of clinically suspected cerebrospinal fluid rhinorrhea in humans: early experience. , 2002, Radiology.

[30]  J. Klisch,et al.  Intrathecal gadolinium-enhanced MR-cisternography: depiction of the subarachnoidal space and evaluation of gadobenat-dimeglumin-(Gd-BOPTA, "Multihance") toxicity in an animal model and a clinical case. , 2002, Academic radiology.

[31]  J. Jinkins,et al.  Intrathecal gadolinium-enhanced MR myelography and cisternography: a pilot study in human patients. , 1999, AJR. American journal of roentgenology.

[32]  H. Siebner,et al.  Magnetic resonance ventriculography with gadolinium DTPA: report of two cases , 1997, Neuroradiology.