α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapy

[1]  Xiaohua Li,et al.  Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin , 2012, Neuropharmacology.

[2]  L. Hein,et al.  Are the pharmacology and physiology of α2adrenoceptors determined by α2‐heteroreceptors and autoreceptors respectively? , 2012, British journal of pharmacology.

[3]  S. Avissar,et al.  Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway. , 2011, The international journal of neuropsychopharmacology.

[4]  R. Lefkowitz,et al.  β-Arrestin-mediated receptor trafficking and signal transduction. , 2011, Trends in pharmacological sciences.

[5]  Yunjia Chen,et al.  The Antidepressant Desipramine Is an Arrestin-biased Ligand at the α2A-Adrenergic Receptor Driving Receptor Down-regulation in Vitro and in Vivo* , 2011, The Journal of Biological Chemistry.

[6]  D. Quartermain,et al.  Antidepressant-like action of intracerebral 6-fluoronorepinephrine, a selective full α-adrenoceptor agonist. , 2011, The international journal of neuropsychopharmacology.

[7]  D. Gurwitz,et al.  Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. , 2011, Pharmacogenomics.

[8]  F. Pilar-Cuéllar,et al.  α2-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims , 2010, Biological Psychiatry.

[9]  D. Puigdemont,et al.  Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: Antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients , 2010, European Neuropsychopharmacology.

[10]  L. Leventhal,et al.  Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. , 2010, The international journal of neuropsychopharmacology.

[11]  S. Hyman,et al.  Animal models of neuropsychiatric disorders , 2010, Nature Neuroscience.

[12]  Yunjia Chen,et al.  Enhanced Hypotensive, Bradycardic, and Hypnotic Responses to α2-Adrenergic Agonists in Spinophilin-Null Mice Are Accompanied by Increased G Protein Coupling to the α2A-Adrenergic Receptor , 2010, Molecular Pharmacology.

[13]  R. Parsey,et al.  Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors. , 2010, Bioorganic & medicinal chemistry letters.

[14]  S. Leurgans,et al.  Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. , 2010, Archives of general psychiatry.

[15]  S. Avissar,et al.  Normalization of GRK2 protein and mRNA measures in patients with depression predict response to antidepressants. , 2010, The international journal of neuropsychopharmacology.

[16]  Lutz Hein,et al.  α2-Adrenoceptor Blockade Accelerates the Neurogenic, Neurotrophic, and Behavioral Effects of Chronic Antidepressant Treatment , 2010, The Journal of Neuroscience.

[17]  D. Winder,et al.  α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis , 2009, Neuroscience.

[18]  Paul J. Harrison,et al.  Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy. , 2009, The international journal of neuropsychopharmacology.

[19]  J. Weiss,et al.  Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons. , 2009, The international journal of neuropsychopharmacology.

[20]  S. Avissar,et al.  Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions. , 2009, Current pharmaceutical design.

[21]  M. Brede,et al.  Genetic Dissection of α2-Adrenoceptor Functions in Adrenergic versus Nonadrenergic Cells , 2009, Molecular Pharmacology.

[22]  S. Sara.  The locus coeruleus and noradrenergic modulation of cognition , 2009, Nature Reviews Neuroscience.

[23]  C. Léránth,et al.  Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression , 2009, Biological Psychiatry.

[24]  J. O'Donnell,et al.  Postsynaptic α-2 Adrenergic Receptors are Critical for the Antidepressant-Like Effects of Desipramine on Behavior , 2009, Neuropsychopharmacology.

[25]  D. Giuliani,et al.  Effects of chronic desipramine treatment on α2-adrenoceptors and μ-opioid receptors in the guinea pig cortex and hippocampus , 2008 .

[26]  R. Belmaker,et al.  Major depressive disorder. , 2008, The New England journal of medicine.

[27]  S. Andersen,et al.  Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model , 2008, Synapse.

[28]  L. Hein,et al.  α2-Adrenoceptor subtypes—Unexpected functions for receptors and ligands derived from gene-targeted mouse models , 2007, Neurochemistry International.

[29]  J. Micó,et al.  In Vivo Effect of Venlafaxine on Locus Coeruleus Neurons: Role of Opioid, α2-Adrenergic, and 5-Hydroxytryptamine1A Receptors , 2007, Journal of Pharmacology and Experimental Therapeutics.

[30]  D. Bylund,et al.  Differential Effects of the Tricyclic Antidepressant Desipramine on the Density of Adrenergic Receptors in Juvenile and Adult Rats , 2007, Journal of Pharmacology and Experimental Therapeutics.

[31]  D. McCormick,et al.  α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex , 2007, Cell.

[32]  Qin Wang,et al.  Regulation of α2AR trafficking and signaling by interacting proteins , 2007 .

[33]  R. Gainetdinov,et al.  Physiological roles of G protein-coupled receptor kinases and arrestins. , 2007, Annual review of physiology.

[34]  D. Giuliani,et al.  Functional interaction between α2-adrenoceptors, μ- and κ-opioid receptors in the guinea pig myenteric plexus: Effect of chronic desipramine treatment , 2006 .

[35]  Donald F. Smith,et al.  Detection of α2-Adrenergic Receptors in Brain of Living Pig with 11C-Yohimbine , 2006 .

[36]  B. Kobilka,et al.  Differential targeting and function of α2A and α2C adrenergic receptor subtypes in cultured sympathetic neurons , 2006, Neuropharmacology.

[37]  V. Ladevèze,et al.  Spinophilin: from partners to functions. , 2006, Biochimie.

[38]  J. González-Maeso,et al.  Heterotrimeric g proteins: insights into the neurobiology of mood disorders. , 2006, Current neuropharmacology.

[39]  Qin Wang,et al.  Arrestin Serves as a Molecular Switch, Linking Endogenous α2-Adrenergic Receptor to SRC-dependent, but Not SRC-independent, ERK Activation* , 2006, Journal of Biological Chemistry.

[40]  W. Drevets,et al.  Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression , 2006, Neuropsychopharmacology.

[41]  S. Avissar,et al.  Dynamics of beta-arrestin1 protein and mRNA levels elevation by antidepressants in mononuclear leukocytes of patients with depression. , 2005, Journal of affective disorders.

[42]  J. Pineda,et al.  α2-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons , 2005 .

[43]  R. Invernizzi,et al.  Chronic Reboxetine Desensitizes Terminal but not Somatodendritic α2-Adrenoceptors Controlling Noradrenaline Release in the Rat Dorsal Hippocampus , 2005, Neuropsychopharmacology.

[44]  C. Belzung,et al.  Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol. , 2005, European journal of pharmacology.

[45]  M. Stern,et al.  α2-Adrenergic Receptors Are Present in Normal Human Conjunctiva , 2005, Current eye research.

[46]  D. Bylund,et al.  Alpha‐2 adrenoceptor subtypes: are more better? , 2005, British journal of pharmacology.

[47]  S. Avissar,et al.  Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. , 2004, The American journal of psychiatry.

[48]  Paul J. Harrison,et al.  Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. , 2004, The American journal of psychiatry.

[49]  P. Escribá,et al.  Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims , 2004, Neuropsychopharmacology.

[50]  P. Greengard,et al.  Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors , 2004, Science.

[51]  M. Brede,et al.  alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. , 2004, Biology of the cell.

[52]  J. Guimón,et al.  Regulation of Platelet α2A-Adrenoceptors, Gi Proteins and Receptor Kinases in Major Depression: Effects of Mirtazapine Treatment , 2004, Neuropsychopharmacology.

[53]  A. Desautels,et al.  Alpha 2A adrenergic receptor gene and suicide , 2004, Psychiatry Research.

[54]  Donald F. Smith,et al.  [N-methyl-11C]Mirtazapine for positron emission tomography neuroimaging of antidepressant actions in humans , 2004, Psychopharmacology.

[55]  K. Vinod,et al.  Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain , 2003, Neurochemistry International.

[56]  J. Sweatt,et al.  Mechanisms of memory. , 2003, Journal of geriatric psychiatry and neurology.

[57]  J. Guimón,et al.  Regulation of GRK 2 and 6, beta-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression. , 2003, Brain research. Molecular brain research.

[58]  W. May,et al.  Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression , 2003, Biological Psychiatry.

[59]  Brian K. Kobilka,et al.  Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine , 2002, The Journal of Neuroscience.

[60]  E. Gould,et al.  Preclinical models: status of basic research in depression , 2002, Biological Psychiatry.

[61]  M. Brede,et al.  Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[62]  J. Mendlewicz,et al.  Mirtazapine, but not fluvoxamine, normalizes the blunted REM sleep response to clonidine in depressed patients: implications for subsensitivity of alpha2-adrenergic receptors in depression , 2002, Psychiatry Research.

[63]  D. Marazziti,et al.  Correlation between Platelet α2-Adrenoreceptors and Symptom Severity in Major Depression , 2001, Neuropsychobiology.

[64]  C. Stefanis,et al.  Melatonin response to clonidine administration in depression: indication of presynaptic alpha2-adrenoceptor dysfunction. , 2001, Journal of affective disorders.

[65]  Y. Mateo,et al.  Acute and chronic effects of desipramine and clorgyline on α2‐adrenoceptors regulating noradrenergic transmission in the rat brain: a dual‐probe microdialysis study , 2001, British journal of pharmacology.

[66]  M. P. McDonald,et al.  The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety , 2001, The Journal of Neuroscience.

[67]  I. Hindmarch.  Expanding the horizons of depression: beyond the monoamine hypothesis , 2001, Human psychopharmacology.

[68]  L. Stinus,et al.  Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test , 2001, Neuropsychopharmacology.

[69]  J. Weiss,et al.  Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity , 2001, Biological Psychiatry.

[70]  S. Liggett,et al.  An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human α2A-Adrenergic Receptor Imparts Enhanced Agonist-promoted Gi Coupling* , 2000, The Journal of Biological Chemistry.

[71]  P. Greengard,et al.  Spinophilin regulates the formation and function of dendritic spines. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[72]  S. Liggett,et al.  A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α2C-Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors* , 2000, The Journal of Biological Chemistry.

[73]  Abraham Weizman,et al.  Unaltered α2-noradrenergic/imidazoline receptors in suicide victims: a postmortem brain autoradiographic analysis , 2000, European Neuropsychopharmacology.

[74]  J. Kable,et al.  In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors. , 2000, The Journal of pharmacology and experimental therapeutics.

[75]  A. Rush,et al.  Platelet alpha2A-adrenoceptor function in major depression: Gi coupling, effects of imipramine and relationship to treatment outcome , 1999, Psychiatry Research.

[76]  B. Kobilka,et al.  Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission , 1999, Nature.

[77]  J. Haycock,et al.  Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression , 1999, Biological Psychiatry.

[78]  T. Svensson,et al.  Locus coeruleus neuronal activity and noradrenaline availability in the frontal cortex of rats chronically treated with imipramine: effect of α2-adrenoceptor blockade , 1999, Biological Psychiatry.

[79]  M. Scheinin,et al.  Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels , 1999, Molecular Psychiatry.

[80]  S. Esteban,et al.  Activation and desensitization by cyclic antidepressant drugs of α2-autoreceptors, α2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

[81]  G. Rajkowska,et al.  Brain Noradrenergic Receptors in Major Depression and Schizophrenia , 1999, Neuropsychopharmacology.

[82]  D. Bernstein,et al.  Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. , 1999, Molecular pharmacology.

[83]  J. Guimón,et al.  Up‐Regulation of Immunolabeled α2A‐Adrenoceptors, Gi Coupling Proteins, and Regulatory Receptor Kinases in the Prefrontal Cortex of Depressed Suicides , 1999, Journal of neurochemistry.

[84]  J. McNamara,et al.  Evaluation of the α2A-adrenergic receptor gene in a heritable form of temporal lobe epilepsy , 1998, Neurology.

[85]  Y. Mateo,et al.  Somatodendritic α2‐Adrenoceptors in the Locus Coeruleus Are Involved in the In Vivo Modulation of Cortical Noradrenaline Release by the Antidepressant Desipramine , 1998, Journal of neurochemistry.

[86]  E. Werstiuk,et al.  Effects of electroconvulsive therapy and desipramine on neuroendocrine responses to the clonidine challenge test. , 1998, Journal of psychiatry & neuroscience : JPN.

[87]  Jeremy G Richman,et al.  α2-Adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. , 1998, American journal of physiology. Cell physiology.

[88]  Á. Pazos,et al.  Selective Increase of α2A‐Adrenoceptor Agonist Binding Sites in Brains of Depressed Suicide Victims , 1998, Journal of neurochemistry.

[89]  Y. Hata,et al.  Neurabin-II/Spinophilin , 1998, The Journal of Biological Chemistry.

[90]  H. Meltzer,et al.  Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression , 1997, The Journal of Neuroscience.

[91]  L. Balant,et al.  Density of Guanine Nucleotide-Binding Proteins in Platelets of Patients with Major Depression: Increased Abundance of the Gαi2 Subunit and Down-Regulation by Antidepressant Drug Treatment , 1997, Biological Psychiatry.

[92]  L. Stone,et al.  The α2a Adrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α2 Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy , 1997, The Journal of Neuroscience.

[93]  P. Greengard,et al.  Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[94]  C. Katona,et al.  Brain α-adrenoceptors in depressed suicides , 1997, Brain Research.

[95]  M. Sastre,et al.  Densities of I2-imidazoline receptors, α 2-adrenoceptors and monoamine oxidase B in brains of suicide victims , 1997, Neurochemistry International.

[96]  H. Shannon,et al.  Effects of Electroconvulsive Therapy on Peripheral Adrenoceptors, Plasma, Noradrenaline, MHPG and Cortisol in Depressed Patients , 1996, British Journal of Psychiatry.

[97]  R. Fremeau,et al.  EXPRESSION OF α2-ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS , 1996, Neuroscience.

[98]  T. Kenakin,et al.  The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. , 1996, Journal of theoretical biology.

[99]  L. Macmillan,et al.  Central Hypotensive Effects of the α2a-Adrenergic Receptor Subtype , 1996, Science.

[100]  M. Sastre,et al.  α2‐Adrenoceptor Subtypes Identified by [3H]RX821002 Binding in the Human Brain: The Agonist Guanoxabenz Does Not Discriminate Different Forms of the Predominant α2A Subtype , 1994 .

[101]  G. Ordway,et al.  Agonist Binding to α2‐Adrenoceptors Is Elevated in the Locus Coeruleus from Victims of Suicide , 1994 .

[102]  Á. Pazos,et al.  Autoradiographic Demonstration of Increased α2‐Adrenoceptor Agonist Binding Sites in the Hippocampus and Frontal Cortex of Depressed Suicide Victims , 1994, Journal of neurochemistry.

[103]  P. Molinoff,et al.  International Union of Pharmacology nomenclature of adrenoceptors. , 1994, Pharmacological reviews.

[104]  J. Haycock,et al.  Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims , 1994, Journal of neurochemistry.

[105]  V. Arango,et al.  Quantitative autoradiography of α 1- and α 2-adrenergic receptors in the cerebral cortex of controls and suicide victims , 1993, Brain Research.

[106]  J. Piletz,et al.  Delayed Desensitization of α2-Adrenoceptor-Mediated Platelet Aggregation in Depressed Patients , 1993, Neuropsychopharmacology.

[107]  R. Lefkowitz,et al.  A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.

[108]  J. García-Sevilla,et al.  Long term treatment with desipramine increases the turnover of alpha 2-adrenoceptors in the rat brain. , 1992, Molecular pharmacology.

[109]  J. Gaillard,et al.  Platelet membrane alpha2-adrenergic receptors in depression , 1992, Psychiatry Research.

[110]  Philip D. Harvey,et al.  Noradrenergic responses to clonidine in acute and remitted depressed male patients , 1992, Psychiatry Research.

[111]  E. Werstiuk,et al.  Platelet alpha 2-adrenergic receptors in depressed patients and healthy volunteers: the effects of desipramine. , 1992, Pharmacopsychiatry.

[112]  G. Vauquelin,et al.  Regional Distribution of α2A‐and α2B‐Adrenoceptor Subtypes in Postmortem Human Brain , 1992 .

[113]  J. Balldin,et al.  Neuroendocrine evidence for decreased function of alpha2-adrenergic receptor after electroconvulsive therapy , 1992, Psychiatry Research.

[114]  B. Kobilka,et al.  Adrenergic receptors as models for G protein-coupled receptors. , 1992, Annual review of neuroscience.

[115]  W. White,et al.  Platelet alpha 2-adrenoceptors, defined with agonist and antagonist ligands, in depressed patients, prior to and following treatment. , 1991, Journal of affective disorders.

[116]  S. Weiss,et al.  Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia. , 1991, Research communications in chemical pathology and pharmacology.

[117]  M. Marler,et al.  Desipramine lowers tritiated para-aminoclonidine binding in platelets of depressed patients. , 1991, Archives of general psychiatry.

[118]  L. Cervo,et al.  Clonidine causes antidepressant-like effects in rats by activating alpha 2-adrenoceptors outside the locus coeruleus. , 1991, European journal of pharmacology.

[119]  J. Piletz,et al.  Elevated 3H-para-aminoclonidine binding to platelet purified plasma membranes from depressed patients. , 1990, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[120]  L. Cervo,et al.  α2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test , 1990 .

[121]  C. Katona,et al.  [3H]Yohimbine binding to platelet α2-adrenoceptors in depression , 1989 .

[122]  J. García-Sevilla,et al.  Acute and long-term regulation of brain alpha 2-adrenoceptors after manipulation of noradrenergic transmission in the rat. , 1989, European journal of pharmacology.

[123]  P. Janicak,et al.  Increased 3H-Clonidine binding in the platelets of patients with depressive and Schizophrenic disorders , 1989, Psychiatry Research.

[124]  武田 俊彦.  Platelet 3H-clonidine and 3H-imipramine binding and plasma cortisol level in depression. , 1989 .

[125]  J. McGrath.  Alpha2-adrenergic receptors: Edited by Lee E. Limbird, Humana Press, 1988. $69.50 in USA ($79.50 elsewhere) (xi + 367 pages) ISBN 0 89603 135 7 , 1989 .

[126]  A. Gelenberg,et al.  Alpha2-adrenergic receptor sensitivity in depressed patients: Relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension , 1989, Biological Psychiatry.

[127]  D. Charney,et al.  alpha 2-Adrenergic receptor sensitivity in depression. The plasma MHPG, behavioral, and cardiovascular responses to yohimbine. , 1988, Archives of general psychiatry.

[128]  L. Limbird.  Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[129]  R. Duman,et al.  In vivo or in vitro exposure to imipramine reduces α 2-adrenoceptor-mediated inhibition of cyclic AMP production in rat brain cerebral cortical slices , 1987, Brain Research.

[130]  C. Udina,et al.  Enhanced binding of [3H] (‐) adrenaline to platelets of depressed patients with melancholia: Effect of long‐term clomipramine treatment , 1987, Acta psychiatrica Scandinavica.

[131]  B. Cohen,et al.  Alpha2-adrenergic receptors in platelet membranes of depressed patients: Increased affinity for 3H-yohimbine , 1987, Psychiatry Research.

[132]  V. Russell,et al.  Alpha2-adrenoceptor levels on platelets of patients with major depressive disorders , 1986, Psychiatry Research.

[133]  B. Leonard,et al.  Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. , 1985, Journal of affective disorders.

[134]  S. Cooper,et al.  Adrenergic Receptors in Depression , 1985, British Journal of Psychiatry.

[135]  C. Thompson,et al.  Effects of Desipramine Treatment upon Central Adrenoceptor Function in Normal Subjects , 1984, British Journal of Psychiatry.

[136]  A. Zis,et al.  Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy , 1983, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[137]  S. Stahl,et al.  Platelet alpha2-adrenergic receptor sensitivity in major depressive disorder , 1983, Psychiatry Research.

[138]  S. Checkley,et al.  The Effect of Desipramine upon Central Adrenergic Function in Depressed Patients , 1982, British Journal of Psychiatry.

[139]  R. Roth,et al.  Presynaptic adrenergic receptor sensitivity in depression. The effect of long-term desipramine treatment. , 1981, Archives of general psychiatry.

[140]  A. Zis,et al.  Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment. , 1981, Archives of general psychiatry.

[141]  J. García-Sevilla,et al.  α2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment , 1981, Brain Research.

[142]  R. Lefkowitz,et al.  A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. , 1980, The Journal of biological chemistry.

[143]  R. Porsolt,et al.  Depression: a new animal model sensitive to antidepressant treatments , 1977, Nature.

[144]  J. Schildkraut,et al.  The catecholamine hypothesis of affective disorders: a review of supporting evidence. , 1965, The American journal of psychiatry.

[145]  A. Short.  CELL SURFACE RECEPTORS : A Short Course on Theory and Methods , 2013 .

[146]  A. Mushegian,et al.  G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. , 2012, Pharmacology & therapeutics.

[147]  Yunjia Chen,et al.  Genetic variations of α(2)-adrenergic receptors illuminate the diversity of receptor functions. , 2011, Current topics in membranes.

[148]  L. Hein,et al.  Pre- versus postsynaptic signaling by α(2)-adrenoceptors. , 2011, Current topics in membranes.

[149]  D. Giuliani,et al.  Effects of chronic desipramine treatment on alpha2-adrenoceptors and mu-opioid receptors in the guinea pig cortex and hippocampus. , 2008, European journal of pharmacology.

[150]  L. Limbird,et al.  Regulation of alpha2AR trafficking and signaling by interacting proteins. , 2007, Biochemical pharmacology.

[151]  J. Pineda,et al.  alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons. , 2005, European journal of pharmacology.

[152]  J. García-Sevilla,et al.  Increasedα 2;-adrenoceptor density in the frontal cortex of depressed suicide victims , 2005, Journal of Neural Transmission.

[153]  J. García-Sevilla,et al.  Modulation by antidepressant drugs of CNS postsynaptic α2-adrenoceptors mediating mydriasis in the rat , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[154]  P. Escribá,et al.  Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. , 2004, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[155]  Michel Bourin,et al.  Forced swimming test in mice: a review of antidepressant activity , 2004, Psychopharmacology.

[156]  J. Guimón,et al.  Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of α2A-adrenoceptors , 2002, Molecular Psychiatry.

[157]  M. P. McDonald,et al.  The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. , 2001, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[158]  G. Cassano,et al.  Correlation between platelet alpha(2)-adrenoreceptors and symptom severity in major depression. , 2001, Neuropsychobiology.

[159]  R. Lefkowitz,et al.  G protein-coupled receptor kinases. , 1998, Annual review of biochemistry.

[160]  J. McNamara,et al.  Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. , 1998, Neurology.

[161]  L. Stone,et al.  The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. , 1997, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[162]  L. Macmillan,et al.  Central hypotensive effects of the alpha2a-adrenergic receptor subtype. , 1996, Science.

[163]  L. Limbird.  Cell Surface Receptors: A Short Course on Theory and Methods , 1996, Springer US.

[164]  M. Sastre,et al.  Alpha 2-adrenoceptor subtypes identified by [3H]RX821002 binding in the human brain: the agonist guanoxabenz does not discriminate different forms of the predominant alpha 2A subtype. , 1994, Journal of neurochemistry.

[165]  G. Ordway,et al.  Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. , 1994, Journal of neurochemistry.

[166]  J. Piletz,et al.  Delayed desensitization of alpha 2-adrenoceptor-mediated platelet aggregation in depressed patients. , 1993, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[167]  V. Arango,et al.  Quantitative autoradiography of alpha 1- and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. , 1993, Brain research.

[168]  M. Kaneko,et al.  Platelet alpha-2 adrenergic receptor binding and plasma free 3-methoxy-4-hydroxyphenylethylene glycol in depressed patients before and after treatment with mianserin. , 1992, Neuropsychobiology.

[169]  Á. Pazos,et al.  Alpha 2-adrenoceptors in the brain of depressed suicide victims. , 1992, Clinical neuropharmacology.

[170]  J. De Keyser,et al.  Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain. , 1992, Journal of neurochemistry.

[171]  L. Cervo,et al.  Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test. , 1990, European journal of pharmacology.

[172]  M. Giralt,et al.  Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment. , 1990, Archives of general psychiatry.

[173]  C. Katona,et al.  [3H]yohimbine binding to platelet alpha 2-adrenoceptors in depression. , 1989, Journal of affective disorders.

[174]  J. García-Sevilla,et al.  Increased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victims. , 1987, Journal of neural transmission.

[175]  V. Russell,et al.  Alpha 2-adrenoceptor levels on platelets of patients with major depressive disorders. , 1986, Psychiatry research.

[176]  J. Guimón,et al.  Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment. , 1986, Archives of general psychiatry.

[177]  S. Stahl,et al.  Platelet alpha 2-adrenergic receptor sensitivity in major depressive disorder. , 1983, Psychiatry research.