Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

[1]  E. Mazzon,et al.  Effects of glycogen synthase kinase-3β inhibition on the development of cerulein-induced acute pancreatitis in mice , 2007 .

[2]  Chia-Hsin Liao,et al.  Urocortin Modulates Inflammatory Response and Neurotoxicity Induced by Microglial Activation1 , 2007, The Journal of Immunology.

[3]  H. Kettenmann,et al.  Microglia: active sensor and versatile effector cells in the normal and pathologic brain , 2007, Nature Neuroscience.

[4]  E. Ling,et al.  Dexamethasone suppresses monocyte chemoattractant protein‐1 production via mitogen activated protein kinase phosphatase‐1 dependent inhibition of Jun N‐terminal kinase and p38 mitogen‐activated protein kinase in activated rat microglia , 2007, Journal of neurochemistry.

[5]  R. Jope,et al.  Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics , 2007, Neurochemical Research.

[6]  T. Giese,et al.  GSK-3 mediates differentiation and activation of proinflammatory dendritic cells. , 2007, Blood.

[7]  P. Moore,et al.  Hydrogen sulfide attenuates lipopolysaccharide‐induced inflammation by inhibition of p38 mitogen‐activated protein kinase in microglia , 2007, Journal of neurochemistry.

[8]  C. Liang,et al.  In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro , 2007, Nature Protocols.

[9]  C. Hoogenraad,et al.  GSK‐3β‐regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome , 2006, The EMBO journal.

[10]  W. Gan,et al.  The P2Y12 receptor regulates microglial activation by extracellular nucleotides , 2006, Nature Neuroscience.

[11]  L. M. Yu,et al.  Preparation of organotypic hippocampal slice cultures: interface method , 2006, Nature Protocols.

[12]  E. Mazzon,et al.  Inhibition of glycogen synthase kinase‐3β attenuates the development of carrageenan‐induced lung injury in mice , 2006 .

[13]  S. Hussain,et al.  Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. , 2006, Cancer research.

[14]  E. Mazzon,et al.  Glycogen Synthase Kinase-3β Inhibition Reduces Secondary Damage in Experimental Spinal Cord Trauma , 2006, Journal of Pharmacology and Experimental Therapeutics.

[15]  R. Jope,et al.  The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways , 2006, Progress in Neurobiology.

[16]  M. Dailey,et al.  Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis , 2006, Glia.

[17]  E. Mazzon,et al.  Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse. , 2006, Clinical immunology.

[18]  R. N. Saha,et al.  Regulation of inducible nitric oxide synthase gene in glial cells. , 2006, Antioxidants & redox signaling.

[19]  K. Pahan,et al.  Up-regulation of Microglial CD11b Expression by Nitric Oxide* , 2006, Journal of Biological Chemistry.

[20]  Rizwan U. Farooqui,et al.  Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. , 2006, Experimental cell research.

[21]  Xinming Cai,et al.  Glycogen Synthase Kinase 3- and Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Paxillin Regulates Cytoskeletal Rearrangement , 2006, Molecular and Cellular Biology.

[22]  C. Haglund,et al.  Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3β in Gastric Cancer Cells* , 2006, Journal of Biological Chemistry.

[23]  T. Asahara,et al.  Glycogen Synthase Kinase 3 and h-prune Regulate Cell Migration by Modulating Focal Adhesions , 2006, Molecular and Cellular Biology.

[24]  J. Ambati,et al.  HIV‐1 Tat and opiate‐induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP‐1 and alternative chemokines , 2006, Glia.

[25]  S. Hanks,et al.  Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. , 2005, The Biochemical journal.

[26]  J. de Vellis,et al.  Microglia in health and disease , 2005, Journal of neuroscience research.

[27]  R. Jope,et al.  Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3 , 2005, Nature Immunology.

[28]  W. Gan,et al.  ATP mediates rapid microglial response to local brain injury in vivo , 2005, Nature Neuroscience.

[29]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[30]  M. Wirenfeldt,et al.  Microglial cell population dynamics in the injured adult central nervous system , 2005, Brain Research Reviews.

[31]  K. Kaibuchi,et al.  GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity , 2005, Cell.

[32]  A. Pautz,et al.  Regulation of the expression of inducible nitric oxide synthase. , 2004, European journal of pharmacology.

[33]  B. Aggarwal,et al.  Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor* , 2004, Journal of Biological Chemistry.

[34]  Kirk W. Johnson,et al.  Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. , 2004, Current pharmaceutical design.

[35]  P. Cohen,et al.  D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a , 2004, EMBO reports.

[36]  J. Cho,et al.  Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3β (GSK3β) plays a critical role in regulating tau's ability to bind and stabilize microtubules , 2003, Journal of neurochemistry.

[37]  C. Hao,et al.  Hypertonic Stress Activates Glycogen Synthase Kinase 3β-mediated Apoptosis of Renal Medullary Interstitial Cells, Suppressing an NFκB-driven Cyclooxygenase-2-dependent Survival Pathway* , 2003, Journal of Biological Chemistry.

[38]  R. Owen,et al.  Inhibition of glycogen synthase kinase 3β in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones , 2003, Molecular and Cellular Neuroscience.

[39]  K. Mackie,et al.  Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration , 2003, The Journal of Neuroscience.

[40]  A. Hall,et al.  Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity , 2003, Nature.

[41]  M. Dragunow,et al.  Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. , 2003, Brain research. Molecular brain research.

[42]  Sang-Gu Hwang,et al.  Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes. , 2002, Biochemical and biophysical research communications.

[43]  P. Marconi,et al.  Effects of Microenvironment on Morphology and Function of the Microglial Cell Line BV-2 , 2001, Neurochemical Research.

[44]  R. Jope,et al.  The multifaceted roles of glycogen synthase kinase 3β in cellular signaling , 2001, Progress in Neurobiology.

[45]  H. Inoue,et al.  Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. , 2001, Cancer research.

[46]  K. Jeng,et al.  Dehydroepiandrosterone inhibits lipopolysaccharide‐induced nitric oxide production in BV‐2 microglia , 2001, Journal of neurochemistry.

[47]  G L Snyder,et al.  Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? , 2001, The Journal of biological chemistry.

[48]  W. Fantl,et al.  Regulation of Cyclooxygenase-2 and Periostin by Wnt-3 in Mouse Mammary Epithelial Cells* , 2000, The Journal of Biological Chemistry.

[49]  G L Snyder,et al.  Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. , 2000, European journal of biochemistry.

[50]  J W Yates,et al.  Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. , 2000, Chemistry & biology.

[51]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[52]  S. Vogel,et al.  Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 21 , 2000, The Journal of Immunology.

[53]  J. Woodgett,et al.  Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation , 2000, Nature.

[54]  D. Feinstein.  Potentiation of Astroglial Nitric Oxide Synthase Type‐2 Expression by Lithium Chloride , 1998, Journal of neurochemistry.

[55]  Philip R. Cohen,et al.  SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1 , 1995, FEBS letters.

[56]  R. J. Mullen,et al.  NeuN, a neuronal specific nuclear protein in vertebrates. , 1992, Development.

[57]  H. Kettenmann,et al.  An immortalized cell line expresses properties of activated microglial cells , 1992, Journal of neuroscience research.

[58]  F. Bistoni,et al.  Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus , 1990, Journal of Neuroimmunology.

[59]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[60]  B. Kristensen,et al.  Markers for neuronal degeneration in organotypic slice cultures. , 1999, Brain research. Brain research protocols.

[61]  M. Woodroofe,et al.  Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro , 1999, Journal of neuroscience research.

[62]  L Meijer,et al.  Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. , 1997, European journal of biochemistry.