Brain somatostatin concentrations do not decrease in progressive supranuclear palsy.

The concentrations of somatostatin and choline acetyl transferase (CAT) were measured in nine brains from patients with progressive supranuclear palsy (PSP) and compared with those obtained from 19 matched control brains. In PSP, CAT activity was reduced in the caudate nucleus and limbic areas (amygdala, hippocampus and cingulate cortex) but was not different from controls in neocortical areas (frontal and temporal). Somatostatin concentrations were not different from controls in any region tested. In contrast to Alzheimer's disease and Parkinson's disease, intellectual deterioration in PSP is not associated with a deficit in neocortical somatostatin and CAT levels.

[1]  Y. Agid,et al.  Progressive supranuclear palsy: anatomoclinical and biochemical considerations. , 1987, Advances in neurology.

[2]  Benson Df.  Subcortical dementia: a clinical approach. , 1983, Advances in neurology.

[3]  P. R. Kerr.  Consultants at the Periphery , 1966 .

[4]  E K Perry,et al.  Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. , 1978, British medical journal.

[5]  Yves Agid,et al.  A subcortico-cortical cholinergic system is affected in Parkinson's disease , 1983, Brain Research.

[6]  U. Roessmann,et al.  Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations , 1980, Annals of neurology.

[7]  E. Perry,et al.  Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. , 1985, Journal of neurology, neurosurgery, and psychiatry.

[8]  E. Hirsch,et al.  Dopaminergic and cholinergic lesions in progressive supranuclear palsy , 1985, Annals of neurology.

[9]  D. Benson,et al.  Subcortical dementia: a clinical approach. , 1983, Advances in neurology.

[10]  P. Davies.  An update on the neurochemistry of Alzheimer disease. , 1983, Advances in neurology.

[11]  Y. Agid,et al.  Somatostatin and dementia in Parkinson's disease , 1983, Brain Research.

[12]  Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase , 1984, Neurochemistry International.

[13]  Bowen Dm,et al.  Neurochemistry of Alzheimer's disease: an update. , 1982 .

[14]  S. Kish,et al.  Progressive supranuclear palsy: Relationship between extrapyramidal disturbances, dementia, and brain neurotransmitter markers , 1985, Annals of neurology.