Elastophagocytosis in Juvenile Xanthogranuloma: A Case Report.

To the Editor: Juvenile xanthogranuloma (JXG) is the most common type of nonLangerhans cell histiocytosis occurring in childhood. This entity is rare in adults. Clinically, it typically presents as asymptomatic solitary or multiple yellow-orange-brown firm papules or nodules, most commonly affecting the face, neck, and upper trunk. Most often, cutaneous JXG spontaneously involutes over several years. Extracutaneous sites have also been described, including oral, ocular, and lung lesions.1 Cutaneous JXG has only rarely been associated with dermal elastic fiber abnormalities, with only rare reports describing secondary anetoderma occurring after JXG resolution.2,3 In this article, we present a case of JXG exhibiting prominent elastophagocytosis on microscopy. The patient was a 9-year-old girl, with no significant medical history.

[1]  M. Hogeling,et al.  Juvenile xanthogranulomas: Examining single, multiple, and extracutaneous presentations , 2020, Pediatric dermatology.

[2]  M. Mahalingam,et al.  Cutaneous Rosai-Dorfman Disease With Linear Lesions and Monoclonal Gammopathy. , 2017, The American Journal of dermatopathology.

[3]  O. Abbas,et al.  Elastophagocytosis: underlying mechanisms and associated cutaneous entities. , 2014, Journal of the American Academy of Dermatology.

[4]  L. Goldberg,et al.  Elastophagocytosis in extragenital lichen sclerosus , 2010, Journal of cutaneous pathology.

[5]  J. Rodríguez-Peralto,et al.  Anetoderma developing in Juvenile Xanthogranuloma , 2004, International journal of dermatology.

[6]  Tay,et al.  Anetoderma in a patient with juvenile xanthogranuloma , 1999, The British journal of dermatology.

[7]  I. Zaki,et al.  Primary anetoderma: phagocytosis of elastic fibres by macrophages , 1994, Clinical and experimental dermatology.

[8]  Y. Miura,et al.  Xanthoma disseminatum: Report of a case, with histological and ultrastructural studies of skin lesions , 1981 .