Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system.

[1]  Dale L Boger,et al.  Discovering potent and selective reversible inhibitors of enzymes in complex proteomes , 2003, Nature Biotechnology.

[2]  B. Cravatt,et al.  Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase , 2003, The Journal of Neuroscience.

[3]  T. Freund,et al.  A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. , 2002, Chemistry and physics of lipids.

[4]  Raymond C Stevens,et al.  Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling , 2002, Science.

[5]  T. Sotnikova,et al.  Monoamine transporter pharmacology and mutant mice. , 2002, Trends in pharmacological sciences.

[6]  B. Cravatt,et al.  Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. , 2002, The Journal of pharmacology and experimental therapeutics.

[7]  Rowland Rs.  Using X-ray crystallography in drug discovery. , 2002 .

[8]  B. Cravatt,et al.  A missense mutation in human fatty acid amide hydrolase associated with problem drug use , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Nicoll,et al.  Endocannabinoid Signaling in the Brain , 2002, Science.

[10]  K. Waku,et al.  Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. , 2002, Prostaglandins, leukotrienes, and essential fatty acids.

[11]  S. Gaetani,et al.  An anorexic lipid mediator regulated by feeding , 2001, Nature.

[12]  W. A. Chambers,et al.  Pharmacological actions and therapeutic uses of cannabis and cannabinoids , 2001, Anaesthesia.

[13]  M. Zimmermann,et al.  Pathobiology of neuropathic pain. , 2001, European journal of pharmacology.

[14]  B. Cravatt,et al.  Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  K. Waku,et al.  2-Arachidonoylglycerol and the cannabinoid receptors. , 2000, Chemistry and physics of lipids.

[16]  D. Boger,et al.  Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  B. Cravatt,et al.  Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism. , 1999, Biochemistry.

[18]  B. Cravatt,et al.  Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties. , 1999, Biochemistry.

[19]  C. Breivogel,et al.  The Functional Neuroanatomy of Brain Cannabinoid Receptors , 1998, Neurobiology of Disease.

[20]  D. Piomelli,et al.  Control of pain initiation by endogenous cannabinoids , 1998, Nature.

[21]  A. Rice,et al.  The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain , 1998, Pain.

[22]  D. R. Compton,et al.  Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain. , 1998, The Journal of pharmacology and experimental therapeutics.

[23]  E. Ellis,et al.  The biodisposition and metabolism of anandamide in mice. , 1997, The Journal of pharmacology and experimental therapeutics.

[24]  D. Deutsch,et al.  Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. , 1997, Biochemical pharmacology.

[25]  W. A. Hill,et al.  Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. , 1997, Biochemical and biophysical research communications.

[26]  Stephen P. Mayfield,et al.  Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides , 1996, Nature.

[27]  I. Ollmann,et al.  Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide , 1996 .

[28]  A. Yamashita,et al.  2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. , 1995, Biochemical and biophysical research communications.

[29]  Z. Vogel,et al.  Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. , 1995, Biochemical pharmacology.

[30]  R. Lerner,et al.  Chemical characterization of a family of brain lipids that induce sleep. , 1995, Science.

[31]  J. Schwartz,et al.  Formation and inactivation of endogenous cannabinoid anandamide in central neurons , 1994, Nature.

[32]  S. Munro,et al.  Molecular characterization of a peripheral receptor for cannabinoids , 1993, Nature.

[33]  D. Deutsch,et al.  Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. , 1993, Biochemical pharmacology.

[34]  D. Gibson,et al.  Isolation and structure of a brain constituent that binds to the cannabinoid receptor. , 1992, Science.

[35]  T. Bonner,et al.  Structure of a cannabinoid receptor and functional expression of the cloned cDNA , 1990, Nature.

[36]  H. Schmid,et al.  Properties of rat liver N-acylethanolamine amidohydrolase. , 1985, The Journal of biological chemistry.

[37]  P. C. Schmid,et al.  Catabolism of N‐Acylethanolamine Phospholipids by Dog Brain Preparations , 1984, Journal of neurochemistry.

[38]  H. Schmid,et al.  Biosynthesis of N‐Acylethanolamine Phospholipids by Dog Brain Preparations , 1983, Journal of neurochemistry.

[39]  S. Gaetani,et al.  Modulation of anxiety through blockade of anandamide hydrolysis , 2003, Nature Medicine.

[40]  R. Rowland.  Using X-ray crystallography in drug discovery. , 2002, Current opinion in drug discovery & development.

[41]  J. Weiner,et al.  Lysophospholipid receptors. , 2001, Annual review of pharmacology and toxicology.

[42]  B. Cravatt,et al.  Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides. , 2001, Vitamins and hormones.