Endoscopic spectral-domain polarization-sensitive optical coherence tomography system

In this paper, we introduced a fiber-based endoscopic Spectral-domain Polarization-sensitive OCT (SD-PS-OCT) experimental scheme for detecting the internal organ disease, which is based on low-coherence interferometer and two spectrometers. The SD-PS-OCT has the advantages of both Spectral-domain OCT (SD-OCT) and Polarization-sensitive OCT (PS-OCT). It is able to get the real-time image of reflectivity and birefringence distribution of tissue at the same time. The usage of SD-PS-OCT in endoscopic diagnosing system provides it the possibility to detect the internal organ disease. Since SD-PS-OCT can image the pathological changes of biological tissue below surface (1-3mm) with high resolution (1-15μm), it is able to help diagnosing early diseases of internal organs, which makes it a biomedical technology with bright future.

[1]  T. Milner,et al.  Review of polarization sensitive optical coherence tomography and Stokes vector determination. , 2002, Journal of biomedical optics.

[2]  Barry Cense,et al.  Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components. , 2004, Optics letters.

[3]  James G. Fujimoto,et al.  Optical coherence tomography: high-resolution imaging in nontransparent tissue , 1999 .

[4]  Daniel J. Kane,et al.  Simultaneous acquisition of the real and imaginary components in Fourier domain optical coherence tomography using harmonic detection , 2006, SPIE Optics East.

[5]  Barry Cense,et al.  Real-time multi-functional optical coherence tomography. , 2003, Optics express.

[6]  M. V. van Gemert,et al.  Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography , 1997, European Conference on Biomedical Optics.

[7]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[8]  Zhongping Chen,et al.  Polarization Effects in Optical Coherence Tomography of Various Biological Tissues. , 1999, IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society.

[9]  A. Fercher,et al.  Polarization–Sensitive Optical Coherence Tomography of Dental Structures , 1999, Caries Research.

[10]  B. Colston,et al.  Birefringence characterization of biological tissue by use of optical coherence tomography. , 1998, Optics letters.

[11]  D. Kane,et al.  Resolving the Complex Conjugate Ambiguity in FD-OCT by Harmonic Lock-In Detection of the Spectral Interferogram , 2006 .

[12]  T. Yatagai,et al.  Fiber-based polarization-sensitive Fourier domain optical coherence tomography using B-scan-oriented polarization modulation method. , 2006, Optics express.

[13]  Toyohiko Yatagai,et al.  Polarization sensitive Fourier domain optical coherence tomography with continuous polarization modulation , 2006, SPIE BiOS.