Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data

The International Neonatal Consortium recently published a proposed retinopathy of prematurity (ROP) activity scale intended for use in clinical trials after validation. The aim of this study was to validate the ROP activity scale (ROP‐ActS) in a ROP screened cohort with protocol based collected data by evaluating the ability of the ROP‐Act scores to predict ROP treatment. In addition, we aimed to evaluate the scale’s sensitivity characteristic of disease severity by studying association with gestational age (GA) in comparison with conventionally used ROP stage and zone.

[1]  Chien-Chou Hsiao,et al.  Effects of fish oil-containing lipid emulsions on retinopathy of prematurity in very low birth weight infants. , 2019, Pediatrics and neonatology.

[2]  A. Hellström,et al.  New modifications of Swedish ROP guidelines based on 10-year data from the SWEDROP register , 2019, British Journal of Ophthalmology.

[3]  N. Marlow,et al.  Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial , 2019, The Lancet.

[4]  Lois E. H. Smith,et al.  Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials , 2019, JAMA ophthalmology.

[5]  A. Hellström,et al.  Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age , 2018, Acta paediatrica.

[6]  Lois E. H. Smith,et al.  Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical Trial , 2018, JAMA pediatrics.

[7]  C. Gilbert,et al.  Limitations in ROP Programs in 32 Neonatal Intensive Care Units in Five States in Mexico , 2015, BioMed research international.

[8]  A. Hellström,et al.  Evaluation of new guidelines for ROP screening in Sweden using SWEDROP – a national quality register , 2015, Acta ophthalmologica.

[9]  Kerstin Albertsson-Wikland,et al.  Continuous growth reference from 24th week of gestation to 24 months by gender , 2008, BMC pediatrics.

[10]  Anna L. Ells,et al.  The International Classification of Retinopathy of Prematurity revisited. , 2005, Archives of ophthalmology.

[11]  W. Tasman,et al.  Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. , 2004, Archives of ophthalmology.

[12]  T. Chan-Ling,et al.  Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. , 2000, Investigative ophthalmology & visual science.