G proteins in signal transduction.

The last five years have seen major advances in our understanding of the central and generalized role of G-proteins as transducers of receptor signals into effector responses as outlined in Scheme 1. Signal-transducing G pro­ teins, in contrast to other GTP-binding proteins, are heterotrimers formed of one GTP-binding (and hydrolyzing) a subunit, one {3 subunit, and one 'Y subunit. I This increase in knowledge is perhaps best illustrated by the fact that

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