Synthetic Ultra-High-Resolution Millimeter-Wave Imaging for Skin Cancer Detection

This work introduces, for the first time, a millimeter-wave imaging system with a “synthetic” ultra-wide imaging bandwidth of 98 GHz to provide the ultra-high resolutions required for early-stage skin cancer detection. The proposed approach consists of splitting the required ultra-wide imaging bandwidth into four sub-bands, and assigning each sub-band to a separate imaging element, i.e., an antenna radiator. Each of the sub-band antennas transmits and receives signals only at its corresponding sub-band. The captured signals are then combined and processed to form the image of the target. For each sub-band, a Vivaldi tapered slot antenna fed with a combination of substrate-integrated waveguide and coplanar waveguide is designed and microfabricated. Design techniques are also provided for the four similarly-shaped sub-band antennas for achieving excellent impedance matches ($S_{11}$ < –10 dB) and nearly constant gains of 10 dBi over the entire 12–110 GHz bandwidth. The design procedure is validated by comparing the simulated results with measurements performed on the fabricated prototypes. Excellent agreements are obtained between simulations and measurements. Finally, the feasibility of detecting early-stage skin tumors in three dimensions is experimentally verified by employing the sub-band antennas in a synthetic ultra-wideband imaging system with a bandwidth of 98 GHz. Two separate setups, each comprising a dispersive skin-mimicking phantom as well as two dispersive spherical tumors, are constructed for imaging experiments. Lateral and axial resolutions of 200 μm are confirmed, and a successful reconstruction of the spherical tumors is achieved in both cases.

[1]  Jens Bornemann,et al.  New substrate-integrated to coplanar waveguide transition , 2011, 2011 41st European Microwave Conference.

[2]  M C Ziskin,et al.  Millimeter wave dosimetry of human skin , 2008, Bioelectromagnetics.

[3]  D. Deslandes Design equations for tapered microstrip-to-Substrate Integrated Waveguide transitions , 2010, 2010 IEEE MTT-S International Microwave Symposium.

[4]  Emanuele Piuzzi,et al.  Quality and anti-adulteration control of vegetable oils through microwave dielectric spectroscopy , 2010 .

[5]  Ke Wu,et al.  Current and Future Research Trends in Substrate Integrated Waveguide Technology , 2009 .

[6]  Pertti Vainikainen,et al.  Wideband Tapered-Slot Antenna with Corrugated Edges for GPR Applications , 2003, 2003 33rd European Microwave Conference, 2003.

[7]  Negar Tavassolian,et al.  Ultra-Wideband Millimeter-Wave Dielectric Characteristics of Freshly Excised Normal and Malignant Human Skin Tissues , 2018, IEEE Transactions on Biomedical Engineering.

[8]  J. Bornemann,et al.  Linear tapered slot antenna with substrate integrated waveguide feed , 2007, 2007 IEEE Antennas and Propagation Society International Symposium.

[9]  R. Majidi-Ahy,et al.  Propagation modes and dispersion characteristics of coplanar waveguides , 1990 .

[10]  Andrea Bevilacqua,et al.  Integrated SFCW Transceivers for UWB Breast Cancer Imaging: Architectures and Circuit Constraints , 2012, IEEE Transactions on Circuits and Systems I: Regular Papers.

[11]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[12]  Ali Pourziad,et al.  Designing Wideband Tapered-Slot Antennas: A novel method using SIW technology. , 2015, IEEE Antennas and Propagation Magazine.

[13]  Negar Tavassolian,et al.  Ultra-high resolution millimeter-wave imaging for biomedical applications: Feasibility study , 2015, 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[14]  R. N. Anderton,et al.  Millimeter-Wave and Submillimeter-Wave Imaging for Security and Surveillance , 2007, Proceedings of the IEEE.

[15]  Mark Coates,et al.  An Early Clinical Study of Time-Domain Microwave Radar for Breast Health Monitoring , 2016, IEEE Transactions on Biomedical Engineering.

[16]  T. L. Korzeniowski,et al.  Endfire tapered slot antennas on dielectric substrates , 1985 .

[17]  Y. Jiao,et al.  A Microstrip-Fed Logarithmically Tapered Slot Antenna for Wideband Applications , 2009 .

[18]  Amin M. Abbosh,et al.  Lung cancer detection using frequency-domain microwave imaging , 2015 .

[19]  Peng Fei,et al.  A Miniaturized Antipodal Vivaldi Antenna With Improved Radiation Characteristics , 2011, IEEE Antennas and Wireless Propagation Letters.

[20]  R. Judaschke Millimeter-wave twin tapered-slot antenna , 2005, IEEE Microwave and Wireless Components Letters.

[21]  Aly E. Fathy,et al.  Ultra-wide band vivaldi antenna array using low loss SIW power divider and GCPW wide band transition , 2012, 2012 IEEE Radio and Wireless Symposium.

[22]  S. Kharkovsky,et al.  Microwave and Millimeter Wave Nondestructive Evaluation of the Space Shuttle External Tank Insulating Foam , 2005 .

[23]  Justin L. Fernandes,et al.  Wide-bandwidth, wide-beamwidth, high-resolution, millimeter-wave imaging for concealed weapon detection , 2013, Defense, Security, and Sensing.

[24]  Paul M. Meaney,et al.  Enhancing breast tumor detection with near-field imaging , 2002 .

[25]  Adriaan van den Bos,et al.  Resolution: a survey , 1997 .

[26]  Anna N Yaroslavsky,et al.  Continuous wave terahertz transmission imaging of nonmelanoma skin cancers , 2011, Lasers in surgery and medicine.

[27]  L. Perregrini,et al.  Dispersion characteristics of substrate integrated rectangular waveguide , 2002, IEEE Microwave and Wireless Components Letters.

[28]  T. Mikulasek,et al.  Compact wideband Vivaldi antenna array for microwave imaging applications , 2013, 2013 7th European Conference on Antennas and Propagation (EuCAP).

[29]  Weng Cho Chew,et al.  Experimental verification of super resolution in nonlinear inverse scattering , 1998 .

[30]  D. W. van der Weide,et al.  Microwave imaging via space-time beamforming: experimental investigation of tumor detection in multilayer breast phantoms , 2004, IEEE Transactions on Microwave Theory and Techniques.

[31]  E. Madsen,et al.  Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications , 2005, Physics in medicine and biology.

[32]  S. Semenov Microwave tomography: review of the progress towards clinical applications , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[33]  Shouyuan Shi,et al.  Modified Compact Antipodal Vivaldi Antenna for 4–50-GHz UWB Application , 2011, IEEE Transactions on Microwave Theory and Techniques.

[34]  Negar Tavassolian,et al.  Synthetic ultra-wideband antenna for high-resolution millimeter-wave imaging , 2015, 2015 IEEE International Symposium on Antennas and Propagation & USNC/URSI National Radio Science Meeting.

[35]  Ke Wu,et al.  Guided-wave and leakage characteristics of substrate integrated waveguide , 2005, IMS 2005.

[36]  L. Zon,et al.  Melanocytes in development and cancer , 2010, Journal of cellular physiology.

[37]  Sergey Kharkovsky,et al.  Microwave and Millimeter Wave Nondestructive Testing of the Space Shuttle External Tank Insulating Foam , 2005 .

[38]  Thomas E. Hall,et al.  Three-dimensional millimeter-wave imaging for concealed weapon detection , 2001 .

[39]  Ke Wu,et al.  Design Consideration and Performance Analysis of Substrate Integrated Waveguide Components , 2002, 2002 32nd European Microwave Conference.

[40]  D. Schaubert,et al.  Parameter study and design of wide-band widescan dual-polarized tapered slot antenna arrays , 2000 .

[41]  Anna N Yaroslavsky,et al.  Demarcation of nonmelanoma skin cancer margins in thick excisions using multispectral polarized light imaging. , 2003, The Journal of investigative dermatology.