An experiment was conducted to study the effect of oral feeding of lead acetate (in saline) at two levels viz. 15mg / day / rat (group A) and 30 mg / day / rat (group B) in albino rats for 90 days. The study revealed highest lead content of 6.84 ppm in the spleen of rats fed with 30 mg of lead acetate daily. The albino rats fed with lead acetate at the level of 30 mg per animal / day also showed nervous symptoms like hemiplegia and edema in muscle, hyperaemia in liver and necrosis of convoluted tubules in the kidneys. Whereas the groups A rats fed on 15 mg of lead acetate did not have lead in detectable level in other muscle and organs. It is noticed that lead acetate in using large doses could produce symptoms of lead toxicity though not very characteristics and brought about changes in the concentration of other toxic metals in body tissues. Further, sometimes may even alter the storage point of these metals.
[1]
F. Shaw,et al.
Chemical residues in meat
,
1993
.
[2]
A. Hamir,et al.
Acid-fast inclusions in osteoclasts of a lead poisoned dog
,
1983,
Veterinary Record.
[3]
R. Wignall.
Lead poisoning in dogs from eating soil
,
1982,
Veterinary Record.
[4]
R. K. Somers.
Chemical residues in meat.
,
1958,
Journal of the American Veterinary Medical Association.
[5]
D. Dodd,et al.
Clinical Lead-Poisoning in the Dog
,
1956
.
[6]
T. Luckey,et al.
Physiologic and Chemical Basis for Metal Toxicity
,
1977,
Springer US.