Summary In this paper we demonstrated that the overall simulation throughput of full-GPU reservoir simulators can be further improved significantly without any modifications to the software, using NVIDIA’s Multi-Processing-Service and Multi-Instance-GPU infrastructure. For models with just a few thousand cells, a throughput increase of 7x is achieved while for problems with a million cells a 60% improvement is achieved using MPS. Furthermore, when using either MPS or MIG, the smaller models can achieve 80% of the peak achievable performance of larger models. In the context of uncertainty quantification workflows, these performance improvements are significant.