Neuropsychological effects of industrial toxins: a review.

Quantitative assessment of nervous system function is essential in characterizing the nature and extent of impairment in individuals experiencing symptoms following workplace exposure. In recent years, the application of standardized neuropsychological tests to the evaluation of exposure to toxic industrial substances has significantly increased the understanding of the effects of these compounds. Within this review, the specific toxic neuropsychological effects of lead, carbon disulfide, trichloroethylene, perchloroethylene, mercury, styrene, and pesticides are discussed in detail. These discussions draw on our clinical experience with patients exposed to these substances as well as material from the medical literature. Factors affecting the utilization of these tests in occupational settings are also considered.

[1]  Randolph K. Byers,et al.  LATE EFFECTS OF LEAD POISONING ON MENTAL DEVELOPMENT , 1943 .

[2]  L. Kurland,et al.  Minamata disease. The outbreak of a neurologic disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds. , 1960, World neurology.

[3]  G. Stopps,et al.  Psychophysiological testing of human subjects exposed to solvent vapors. , 1967, American Industrial Hygiene Association journal.

[4]  J. Holmes,et al.  EEG, PSYCHOLOGICAL, AND NEUROLOGICAL ALTERATIONS IN HUMANS WITH ORGANOPHOSPHORUS EXPOSURE * , 1969, Annals of the New York Academy of Sciences.

[5]  B. B. Morgan,et al.  Behavioral effects of occupational exposure to lead , 1975 .

[6]  D. Chaffin,et al.  Subclinical psychomotor and neuromuscular changes in workers exposed to inorganic mercury. , 1975, American Industrial Hygiene Association journal.

[7]  B. Chalupa,et al.  The Assessment of Electroencephalographic Changes and Memory Disturbances in Acute Intoxications with Industrial Poisons , 1960, British journal of industrial medicine.

[8]  R. Lilis,et al.  Clinical studies of styrene workers: initial findings. , 1976, Environmental health perspectives.

[9]  O. Axelson,et al.  A case-referent study on neuropsychiatric disorders among workers exposed to solvents. , 1976, Scandinavian journal of work, environment & health.

[10]  H. Härkönen Relationship of symptoms to occupational styrene exposure and to the findings of electroencephalographic and psychological examinations , 1977, International archives of occupational and environmental health.

[11]  R. Feldman,et al.  Evidence for peripheral neurotoxic effect of trichloroethylene , 1970, Neurology.

[12]  H. Hänninen Psychological picture of manifest and latent carbon disulphide poisoning , 1971, British journal of industrial medicine.

[13]  Y. Takeuchi,et al.  Polyneuropathy caused by petroleum benzine , 1975, Internationales Archiv fur Arbeitsmedizin.

[14]  R. D. Stewart,et al.  Human exposure to styrene vapor. , 1968, Archives of environmental health.

[15]  H B Gerstner,et al.  Selected case histories and epidemiologic examples of human mercury poisoning. , 1977, Clinical toxicology.

[16]  S. Hernberg,et al.  Disturbances in psychological functions of workers occupationally exposed to styrene. , 1976, Scandinavian journal of work, environment & health.

[17]  M. Salvini,et al.  Evaluation of the psychophysiological functions in humans exposed to trichloroethylene , 1971, British journal of industrial medicine.

[18]  M. L. Choate,et al.  Early asymptomatic lead exposure and development at school age. , 1975, The Journal of pediatrics.

[19]  A. Seppäläinen,et al.  Exposure-response relationship between styrene exposure and central nervous functions. , 1978, Scandinavian journal of work, environment & health.

[20]  I J Selikoff,et al.  Central nervous system dysfunction due to lead exposure. , 1978, Science.

[21]  J. Shepherd,et al.  Blood-lead levels, behaviour, and intelligence. A population study. , 1974, Lancet.

[22]  Ansford Aj,et al.  Letter: "e" antigen. , 1976 .

[23]  P. Grandjean,et al.  Psychological dysfunctions in lead-exposed workers. Relation to biological parameters of exposure. , 1978, Scandinavian journal of work, environment & health.

[24]  C. Corum,et al.  Effects of inorganic lead on behavioral and neurologic function. Final report , 1977 .

[25]  A. Leviton,et al.  Deficits in psychologic and classroom performance of children with elevated dentine lead levels. , 1979, The New England journal of medicine.

[26]  D. Chaffin,et al.  Evaluation of workers exposed to elemental mercury using quantitative tests of tremor and neuromuscular functions. , 1978, American Industrial Hygiene Association journal.