Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity.

[1]  Y. Reiter,et al.  Recombinant antibodies with T-cell receptor-like specificity: novel tools to study MHC class I presentation. , 2006, Autoimmunity reviews.

[2]  S. Grinstein,et al.  Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation , 2005, Cell.

[3]  D. Palliser,et al.  Multiple Intracellular Routes in the Cross-Presentation of a Soluble Protein by Murine Dendritic Cells1 , 2005, The Journal of Immunology.

[4]  Matthew R. Clutter,et al.  High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. , 2005, Journal of molecular biology.

[5]  S. Russell,et al.  Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor , 2004, Gene Therapy.

[6]  A. Goldberg,et al.  Post-proteasomal antigen processing for major histocompatibility complex class I presentation , 2004, Nature Immunology.

[7]  P. Cresswell,et al.  Cellular mechanisms governing cross-presentation of exogenous antigens , 2004, Nature Immunology.

[8]  E. Unanue,et al.  T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM. , 2004, Immunity.

[9]  H. Schreiber,et al.  Bystander elimination of antigen loss variants in established tumors , 2004, Nature Medicine.

[10]  Mark M Davis,et al.  Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. , 2003, Molecular cell.

[11]  R. Zinkernagel,et al.  Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Davoust,et al.  ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells , 2003, Nature.

[13]  Etienne Gagnon,et al.  Phagosomes are competent organelles for antigen cross-presentation , 2003, Nature.

[14]  A. G. Grandea,et al.  Tapasin−/− and TAP1−/− Macrophages Are Deficient in Vacuolar Alternate Class I MHC (MHC-I) Processing due to Decreased MHC-I Stability at Phagolysosomal pH1 , 2003, The Journal of Immunology.

[15]  T. Hornell,et al.  Homology Between an Alloantigen and a Self MHC Allele Calibrates the Avidity of the Alloreactive T Cell Repertoire Independent of TCR Affinity1 , 2003, The Journal of Immunology.

[16]  S. Jacobson,et al.  Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-Restricted Human Recombinant Antibodies1 , 2003, The Journal of Immunology.

[17]  David M Kranz,et al.  Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. , 2003, Immunity.

[18]  C. Harding,et al.  Processing of Exogenous Antigens for Presentation by Class I MHC Molecules Involves Post-Golgi Peptide Exchange Influenced by Peptide-MHC Complex Stability and Acidic pH , 2003, The Journal of Immunology.

[19]  T. Hornell,et al.  Peptide Length Variants p2Ca and QL9 Present Distinct Conformations to Ld-Specific T Cells1 , 2001, The Journal of Immunology.

[20]  D. Kranz,et al.  Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation , 2001, The Journal of experimental medicine.

[21]  G Capitani,et al.  Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides. , 2001, Journal of molecular biology.

[22]  J. Yewdell,et al.  Multiple Antigen-Specific Processing Pathways for Activating Naive CD8+ T Cells In Vivo , 2001, The Journal of Immunology.

[23]  M R Jackson,et al.  The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity. , 2001, Immunity.

[24]  I. Papayannopoulos,et al.  Potent Cytolytic Response by a CD8+ CTL Clone to Multiple Peptides from the Same Protein in Association with an Allogeneic Class I MHC Molecule1 , 2001, The Journal of Immunology.

[25]  D. Wiley,et al.  Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling. , 2000, Immunity.

[26]  G. Schuler,et al.  Formation and kinetics of MHC class I-ovalbumin peptide complexes on immature and mature murine dendritic cells. , 2000, The Journal of investigative dermatology.

[27]  K D Wittrup,et al.  In vitro evolution of a T cell receptor with high affinity for peptide/MHC. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Jan Engberg,et al.  Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex , 2000, The Journal of experimental medicine.

[29]  K. Garcia,et al.  A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. , 2000, Immunity.

[30]  G. Balendiran,et al.  Structural features of MHC class I molecules that might facilitate alternative pathways of presentation. , 2000, Immunology today.

[31]  J. Neefjes,et al.  Recycling MHC class I molecules and endosomal peptide loading. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[32]  H. Ploegh,et al.  Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. , 1998, Immunity.

[33]  J. Allison,et al.  Secondary but not primary T cell responses are enhanced in CTLA‐4‐deficient CD8+ T cells , 1998, European journal of immunology.

[34]  L. Pease,et al.  Degenerate recognition of alloantigenic peptides on a positive-selecting class I molecule. , 1998, Journal of immunology.

[35]  J. Yewdell,et al.  Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J. Yewdell,et al.  Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. , 1997, Immunity.

[37]  E. Unanue,et al.  Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody. , 1997, Immunity.

[38]  M. Jackson,et al.  Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells , 1997, The Journal of experimental medicine.

[39]  D. Kranz,et al.  A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor. , 1996, Journal of immunology.

[40]  L. Pease,et al.  A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity , 1996, The Journal of experimental medicine.

[41]  S. Kienle,et al.  Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone. , 1996, Journal of immunology.

[42]  H. Eisen,et al.  Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. , 1996, Immunity.

[43]  P. S. Andersen,et al.  A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Jackson,et al.  High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[45]  R. J. Cohen,et al.  Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. , 1994, Immunity.

[46]  R. Steinman,et al.  Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.

[47]  P. A. Peterson,et al.  Emerging principles for the recognition of peptide antigens by MHC class I molecules. , 1992, Science.

[48]  H. Eisen,et al.  A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein , 1992, Cell.

[49]  M. Bevan Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay , 1976, The Journal of experimental medicine.

[50]  R. Tampé,et al.  Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells , 2005, Nature Immunology.

[51]  P. Cresswell,et al.  Differential transport requirements of HLA and H-2 class I glycoproteins , 2004, Immunogenetics.

[52]  David M. Kranz,et al.  TCRs with high affinity for foreign pMHC show self-reactivity , 2003, Nature Immunology.

[53]  Kees Jalink,et al.  Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. , 2003, Immunity.

[54]  A. Goldberg,et al.  Degradation of cell proteins and the generation of MHC class I-presented peptides. , 1999, Annual review of immunology.

[55]  L R Pease,et al.  Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. , 1997, Proceedings of the National Academy of Sciences of the United States of America.