Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway.

[1]  C. Giordano,et al.  Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. , 2012, Journal of ethnopharmacology.

[2]  M. Cascante,et al.  New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells. , 2011, Biochimie.

[3]  Helmut Viernstein,et al.  Comprehensive evaluation of natural antioxidants and antioxidant potentials in Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou fruits based on geographical origin by TOPSIS method , 2011 .

[4]  Eunhye Kim,et al.  Inhibition of cell growth and potentiation of tumor necrosis factor-α (TNF-α)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. , 2010, Biochemical pharmacology.

[5]  Qipeng Yuan,et al.  Preparation and stability investigation of the inclusion complex of sulforaphane with hydroxypropyl-β-cyclodextrin , 2010 .

[6]  Ruihua Lu,et al.  Studies on a novel modified β-cyclodextrin inclusion complex , 2010 .

[7]  S. Kavitha,et al.  Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells. , 2010, International immunopharmacology.

[8]  G. Kroemer,et al.  Targeting mitochondrial apoptosis by betulinic acid in human cancers. , 2009, Drug discovery today.

[9]  Fernando J. Reyes-Zurita,et al.  Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. , 2009, Cancer letters.

[10]  Thorsteinn Loftsson,et al.  Cyclodextrins as pharmaceutical solubilizers. , 2007, Advanced drug delivery reviews.

[11]  J. Medema,et al.  Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. , 2007, Cancer letters.

[12]  W. Tiyaboonchai,et al.  Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. , 2007, International journal of pharmaceutics.

[13]  G. Sledge.  Breast cancer as a world challenge. , 2004, Clinical breast cancer.

[14]  A. Mitra,et al.  Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats , 1994, Pharmaceutical Research.

[15]  D. Green,et al.  A Matter of Life and Death , 2008, Science.

[16]  R. Supino,et al.  Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells. , 2002, Cancer letters.

[17]  Elias S. J. Arnér,et al.  Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. , 2001, Free radical biology & medicine.

[18]  Y. Ohta,et al.  Kinetic and Thermodynamic Analyses of the Cyclodextrin-Allyl Isothiocyanate Inclusion Complex in an Aqueous Solution , 2000, Bioscience, biotechnology, and biochemistry.

[19]  A. Hedges.  Industrial Applications of Cyclodextrins. , 1998, Chemical reviews.

[20]  M. Rieber,et al.  Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma. , 1998, DNA and cell biology.

[21]  M. Peter,et al.  Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. , 1997, Cancer research.

[22]  James B. Mitchell,et al.  Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. , 1987, Cancer research.

[23]  T. Higuchi,et al.  Phase solubility techniques , 1965 .