Improved pregnancy outcomes of cyclosporine A on patients with unexplained repeated implantation failure in IVF/ICSI cycles: A retrospective cohort study

Repeated implantation failure (RIF) is a daunting obstacle restricting the further improvement of embryo implantation rate (IR) and live birth rate (LBR). The beneficial effect of cyclosporine A (CsA) on reproductive outcomes of unexplained RIF(URIF) was explored after de novo embryo transfer (ET).

[1]  P. Leung,et al.  A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China , 2021, The Lancet.

[2]  J. Byeon,et al.  Comparison of outcomes of cyclosporine A and infliximab for steroid‐refractory acute severe ulcerative colitis , 2021, Journal of gastroenterology and hepatology.

[3]  Wenhui Zhou,et al.  Impacts of Cyclosporin A on clinical pregnancy outcomes of patients with a history of unexplained transfer failure: a retrospective cohort study , 2021, Reproductive Biology and Endocrinology.

[4]  Jiangfeng Ye,et al.  Th17/Treg-cell balance in the peripheral blood of pregnant females with a history of recurrent spontaneous abortion receiving progesterone or cyclosporine A. , 2020, Experimental and therapeutic medicine.

[5]  D. Cimadomo,et al.  Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists. , 2020, Human reproduction.

[6]  Qi Li,et al.  Effects of cyclosporine A on proliferation, invasion and migration of HTR-8/SVneo human extravillous trophoblasts. , 2020, Biochemical and biophysical research communications.

[7]  A. Gilman‐Sachs,et al.  T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells , 2020, Frontiers in Immunology.

[8]  J. Ayoubi,et al.  Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. , 2019, Fertility and sterility.

[9]  H. Kurahashi,et al.  Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure. , 2019, Human reproduction.

[10]  Dajin Li,et al.  Cyclosporin A protects trophoblasts from H2O2-induced oxidative injury via FAK-Src pathway. , 2019, Biochemical and biophysical research communications.

[11]  M. Yousefi,et al.  Cyclosporine A improves pregnancy outcomes in women with recurrent pregnancy loss and elevated Th1/Th2 ratio , 2019, Journal of cellular physiology.

[12]  J. Kwak‐Kim,et al.  Obstetric and perinatal outcome of the women with repeated implantation failures or recurrent pregnancy losses who received pre‐ and post‐conception tacrolimus treatment , 2019, American journal of reproductive immunology.

[13]  Wenshan Lin,et al.  Efficacy and safety of cyclosporine A in the treatment of idiopathic membranous nephropathy in an Asian population , 2019, Drug design, development and therapy.

[14]  M. Nouri,et al.  Sirolimus as a new drug to treat RIF patients with elevated Th17/Treg ratio: A double-blind, phase II randomized clinical trial. , 2019, International immunopharmacology.

[15]  Guoning Huang,et al.  Frozen blastocyst embryo transfer vs. frozen cleavage-stage embryo transfer in couples with recurrent implantation failure: a cohort study , 2019, Human fertility.

[16]  F. Staud,et al.  Trophoblast: The central unit of fetal growth, protection and programming. , 2018, The international journal of biochemistry & cell biology.

[17]  B. Huppertz.  The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia , 2018, Current pharmaceutical biotechnology.

[18]  P. Sebastián-León,et al.  Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure† , 2018, Human reproduction.

[19]  J. Kwak‐Kim,et al.  Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures , 2017, American journal of reproductive immunology.

[20]  Hong Zhu,et al.  CsA Promotes XIST Expression to Regulate Human Trophoblast Cells Proliferation and Invasion Through miR‐144/Titin Axis , 2017, Journal of cellular biochemistry.

[21]  Z. Fazlıoğulları,et al.  Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone. , 2016, Regulatory toxicology and pharmacology : RTP.

[22]  N. Raine-Fenning,et al.  What exactly do we mean by 'recurrent implantation failure'? A systematic review and opinion. , 2014, Reproductive biomedicine online.

[23]  Dajin Li,et al.  Cyclosporine A improves adhesion and invasion of mouse preimplantation embryos via upregulating integrin β3 and matrix metalloproteinase-9. , 2014, International journal of clinical and experimental pathology.

[24]  T. Gurgan,et al.  Recurrent implantation failure: definition and management. , 2014, Reproductive biomedicine online.

[25]  Qi Chen,et al.  Cyclosporin A enhances the ability of trophoblasts to displace the activated human umbilical vein endothelial cell monolayers. , 2013, International journal of clinical and experimental pathology.

[26]  Wen-Jie Zhou,et al.  Cyclosporin A promotes crosstalk between human cytotrophoblast and decidual stromal cell through up-regulating CXCL12/CXCR4 interaction. , 2012, Human reproduction.

[27]  Dajin Li,et al.  CsA improves the trophoblasts invasiveness through strengthening the cross-talk of trophoblasts and decidual stromal cells mediated by CXCL12 and CD82 in early pregnancy. , 2012, International journal of clinical and experimental pathology.

[28]  S. Constantinescu,et al.  Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. , 2003, Clinical transplants.

[29]  Wen-hui Zhou,et al.  Cyclosporin A promotes growth and invasiveness in vitro of human first-trimester trophoblast cells via MAPK3/MAPK1-mediated AP1 and Ca2+/calcineurin/NFAT signaling pathways. , 2008, Biology of reproduction.

[30]  Wen-hui Zhou,et al.  Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4. , 2008, Reproduction.

[31]  Wen-hui Zhou,et al.  Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse1 , 2007, Biology of reproduction.

[32]  E. Margalioth,et al.  Investigation and treatment of repeated implantation failure following IVF-ET. , 2006, Human reproduction.

[33]  程海东,et al.  Cyclosporin A induces peripheral maternal-fetal immumo-tolerance of the abortion-prone murine model , 2006 .

[34]  J. Ernerudh,et al.  Immunology of preeclampsia. , 2005, Chemical immunology and allergy.

[35]  E. Staun-ram,et al.  Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion , 2004, Reproductive biology and endocrinology : RB&E.

[36]  Dajin Li,et al.  [Effect of cyclosporin A on the growth of human first trimester cytotrophoblasts in vitro]. , 2002, Zhonghua fu chan ke za zhi.

[37]  M. Moritz,et al.  Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. , 2003, Clinical transplants.

[38]  J. Bach.  The contribution of cyclosporine A to the understanding and treatment of autoimmune diseases. , 1999, Transplantation proceedings.

[39]  T. Strom,et al.  Cyclosporine: a new immunosuppressive agent for organ transplantation. , 1984, Annals of internal medicine.