Vigabatrin-associated retinal cone system dysfunction
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To the Editor: Krauss et al.1 reported visual disturbances in adult patients treated with vigabatrin for epilepsy. Visual field constriction, in particular, was concluded to be associated with retinal cone system dysfunction. However, such symptoms have not been described in children undergoing vigabatrin therapy. The mechanisms underlying this phenomenon are unknown. Nevertheless, we hypothesize a particular age-dependent biochemical pathway involved in vigabatrin-associated retinal dysfunction.
The efficacy of vigabatrin relies on its irreversible …
[1] A. Doria. Genetic Markers of Increased Susceptibility to Diabetic Nephropathy , 1998, Hormone Research in Paediatrics.
[2] R. Ruff. Why do patients with McArdle's disease have decreased exercise capacity? , 1998, Neurology.