The transport of antiepileptic drugs by P-glycoprotein.
暂无分享,去创建一个
P. Kwan | Z. Zuo | L. Baum | Chunbo Zhang
[1] P. Kwan,et al. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P‐glycoprotein , 2011, Epilepsia.
[2] W. Löscher,et al. Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected. , 2011, Current pharmaceutical design.
[3] Gary W. Mathern,et al. Erratum: Definition of drug resistant epilepsy. Consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies (Epilepsia (2010) 51 (1069-77)) , 2010 .
[4] G. Böning,et al. Imaging of P‐glycoprotein–mediated pharmacoresistance in the hippocampus: Proof‐of‐concept in a chronic rat model of temporal lobe epilepsy , 2010, Epilepsia.
[5] A. Kaye,et al. Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy , 2010, Neurobiology of Disease.
[6] P. Kwan,et al. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. , 2010, Life sciences.
[7] J. H. Cross,et al. Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 , 2010, Epilepsia.
[8] M. Niemi,et al. Membrane transporters in drug development , 2010, Nature Reviews Drug Discovery.
[9] G. Mathern,et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies , 2009, Epilepsia.
[10] W. Löscher,et al. The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins , 2009, Pharmaceutical Research.
[11] Wolfgang Löscher,et al. Several major antiepileptic drugs are substrates for human P-glycoprotein , 2008, Neuropharmacology.
[12] Asako Nishimura,et al. Evaluation of carbamazepine pharmacokinetic profiles in mice with kainic acid-induced acute seizures. , 2008, Biological & pharmaceutical bulletin.
[13] Shiew-Mei Huang,et al. A regulatory viewpoint on transporter-based drug interactions , 2008 .
[14] Xiao-dong Liu,et al. Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain , 2008, Journal of the Neurological Sciences.
[15] F. H. Lopes da Silva,et al. Development of tolerance to levetiracetam in rats with chronic epilepsy , 2008, Epilepsia.
[16] S. Bates,et al. P-Glycoprotein—a Clinical Target in Drug-Refractory Epilepsy? , 2008, Molecular Pharmacology.
[17] V. Cardile,et al. Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. , 2008, Current neurovascular research.
[18] Chih-Chuan Chen,et al. Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs , 2008, Pharmacogenetics and genomics.
[19] Xiao-dong Liu,et al. Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro , 2008, Neuroscience Letters.
[20] Xiao-dong Liu,et al. P-glycoprotein-mediated efflux of phenobarbital at the blood-brain barrier evidence from transport experiments in vitro , 2008, Epilepsy Research.
[21] Wolfgang Löscher,et al. Drug resistance in epilepsy: Why is a simple explanation not enough? , 2007, Epilepsia.
[22] K. Mealey,et al. Assessment of antiepileptic drugs as substrates for canine P-glycoprotein. , 2007, American journal of veterinary research.
[23] Xiao-dong Liu,et al. Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats , 2007, Neuropharmacology.
[24] Adorjan Aszalos,et al. Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects. , 2007, Drug discovery today.
[25] M. Iş,et al. Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia , 2007, Seizure.
[26] Alexander Hammers,et al. Pharmacoresistance in Epilepsy : A Pilot PET Study with the P-Glycoprotein Substrate R-[ 11 C ] verapamil ∗ † , 2007 .
[27] Kimura Yasuhisa,et al. Mechanism of multidrug recognition by MDR1/ABCB1 , 2007 .
[28] P. Kwan,et al. Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese , 2007, Epilepsy & Behavior.
[29] E. Aronica,et al. Region-Specific Overexpression of P-glycoprotein at the Blood-Brain Barrier Affects Brain Uptake of Phenytoin in Epileptic Rats , 2007, Journal of Pharmacology and Experimental Therapeutics.
[30] M. Pirmohamed,et al. ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research , 2007, The Pharmacogenomics Journal.
[31] W. Löscher,et al. Upregulation of Brain Expression of P‐Glycoprotein in MRP2‐deficient TR‐ Rats Resembles Seizure‐induced Up‐regulation of This Drug Efflux Transporter in Normal Rats , 2007, Epilepsia.
[32] Luca Cucullo,et al. Development of a Humanized In Vitro Blood–Brain Barrier Model to Screen for Brain Penetration of Antiepileptic Drugs , 2007, Epilepsia.
[33] W. Löscher. Drug Transporters in the Epileptic Brain , 2007, Epilepsia.
[34] X. Chang. A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1 , 2007, Cancer and Metastasis Reviews.
[35] W. Löscher,et al. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein , 2007, Neuropharmacology.
[36] Lippincott-Schwartz,et al. Supporting Online Material Materials and Methods Som Text Figs. S1 to S8 Table S1 Movies S1 to S3 a " Silent " Polymorphism in the Mdr1 Gene Changes Substrate Specificity Corrected 30 November 2007; See Last Page , 2022 .
[37] W. Löscher,et al. Valproic Acid Is Not a Substrate for P-glycoprotein or Multidrug Resistance Proteins 1 and 2 in a Number of in Vitro and in Vivo Transport Assays , 2007, Journal of Pharmacology and Experimental Therapeutics.
[38] A. Vezzani,et al. Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development , 2006, Neurobiology of Disease.
[39] Wolfgang Löscher,et al. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy , 2006, Neurobiology of Disease.
[40] M. Bialer,et al. The antiepileptic and anticancer agent, valproic acid, induces P‐glycoprotein in human tumour cell lines and in rat liver , 2006, British journal of pharmacology.
[41] Yuichi Sugiyama,et al. Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[42] W. Löscher,et al. Comparison of Brain Extracellular Fluid, Brain Tissue, Cerebrospinal Fluid, and Serum Concentrations of Antiepileptic Drugs Measured Intraoperatively in Patients with Intractable Epilepsy , 2006, Epilepsia.
[43] In-Wha Kim,et al. The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[44] E. Aronica,et al. Inhibition of the Multidrug Transporter P‐Glycoprotein Improves Seizure Control in Phenytoin‐treated Chronic Epileptic Rats , 2006, Epilepsia.
[45] Y. Yonekawa,et al. Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis , 2006, Epilepsy Research.
[46] M. Klein,et al. Insight in eukaryotic ABC transporter function by mutation analysis , 2006, FEBS letters.
[47] H. Stefan,et al. Influence of Lamotrigine and Topiramate on MDR1 Expression in Difficult‐to‐Treat Temporal Lobe Epilepsy , 2006, Epilepsia.
[48] A. Crowe,et al. Limited P-glycoprotein mediated efflux for anti-epileptic drugs , 2006, Journal of drug targeting.
[49] C. Baumgartner,et al. A Pilot Study on Brain‐to‐Plasma Partition of 10,11‐Dyhydro‐10‐hydroxy‐5H‐dibenzo(b,f)azepine‐5‐carboxamide and MDR1 Brain Expression in Epilepsy Patients Not Responding to Oxcarbazepine , 2005, Epilepsia.
[50] Ellen B. Wolpert,et al. Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells , 2005, Neuropharmacology.
[51] R. Sun,et al. [Expression of multidrug resistance gene and topiramate affect expression of multidrug resistance gene in the hippocampus of spontaneous epileptic rats]. , 2005, Zhonghua er ke za zhi = Chinese journal of pediatrics.
[52] Wolfgang Löscher,et al. Drug resistance in brain diseases and the role of drug efflux transporters , 2005, Nature Reviews Neuroscience.
[53] C. Baumgartner,et al. Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans , 2005, Clinical pharmacology and therapeutics.
[54] W. Löscher,et al. Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures. , 2005, Brain : a journal of neurology.
[55] Dieter Schmidt,et al. Drug Resistance in Epilepsy: Putative Neurobiologic and Clinical Mechanisms , 2005, Epilepsia.
[56] P. Kwan,et al. Potential Role of Drug Transporters in the Pathogenesis of Medically Intractable Epilepsy , 2005, Epilepsia.
[57] W. Löscher,et al. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures , 2004, Neuroscience.
[58] Xue-feng Wang,et al. Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes cultured from rat brains. , 2004, Chinese medical journal.
[59] A. Vezzani,et al. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain , 2004 .
[60] Michael Zschiesche,et al. Carbamazepine regulates intestinal P‐glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans , 2004, Clinical pharmacology and therapeutics.
[61] W. Löscher,et al. Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats , 2004, Neuroreport.
[62] E. Aronica,et al. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats , 2004, Epilepsy Research.
[63] M. Nedergaard,et al. The blood–brain barrier: an overview Structure, regulation, and clinical implications , 2004, Neurobiology of Disease.
[64] J. Beijnen,et al. Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein. , 2004, European journal of cancer.
[65] J. C. Baayen,et al. Expression and Cellular Distribution of Multidrug Resistance–related Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy , 2004, Epilepsia.
[66] D. Begley,et al. ABC transporters and the blood-brain barrier. , 2004, Current pharmaceutical design.
[67] G. Sevlever,et al. Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy. , 2004, Pediatric neurology.
[68] W. Löscher,et al. Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats , 2004, Epilepsy Research.
[69] Chava Kimchi-Sarfaty,et al. P-glycoprotein: from genomics to mechanism , 2003, Oncogene.
[70] W. Haefeli,et al. Interaction of Antiepileptic Drugs with Human P-Glycoprotein in Vitro , 2003, Journal of Pharmacology and Experimental Therapeutics.
[71] Yuichi Sugiyama,et al. Impact of Drug Transporter Studies on Drug Discovery and Development , 2003, Pharmacological Reviews.
[72] Willem Boogerd,et al. Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[73] E. Aronica,et al. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors , 2003, Neuroscience.
[74] H. Stefan,et al. A Kindling Model of Pharmacoresistant Temporal Lobe Epilepsy in Sprague–Dawley Rats Induced by Coriaria Lactone and Its Possible Mechanism , 2003, Epilepsia.
[75] Stephen A. Wring,et al. Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs , 2002, Journal of Pharmacology and Experimental Therapeutics.
[76] Armin Buschauer,et al. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. , 2002, The Journal of clinical investigation.
[77] S. Moshé,et al. Models for Epilepsy and Epileptogenesis: Report from the NIH Workshop, Bethesda, Maryland , 2002, Epilepsia.
[78] Wolfgang Löscher,et al. Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy , 2002, Epilepsy Research.
[79] Graeme J. Sills,et al. P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice , 2002, Epilepsy & Behavior.
[80] W. Löscher,et al. Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions. , 2002, European journal of pharmacology.
[81] W. Löscher,et al. P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood–brain barrier: evidence from microdialysis experiments in rats , 2002, Neuroscience Letters.
[82] E. Aronica,et al. Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance , 2002, The Journal of Neuroscience.
[83] W. Löscher,et al. Expression of the Multidrug Transporter P‐glycoprotein in Brain Capillary Endothelial Cells and Brain Parenchyma of Amygdala‐kindled Rats , 2002, Epilepsia.
[84] R. Béliveau,et al. Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier. , 2002, Vascular pharmacology.
[85] R. Bendayan,et al. Functional expression and localization of P‐glycoprotein at the blood brain barrier , 2002, Microscopy research and technique.
[86] Terry R Stouch,et al. Progress in understanding the structure-activity relationships of P-glycoprotein. , 2002, Advanced drug delivery reviews.
[87] M. Mayberg,et al. Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy , 2001, Epilepsia.
[88] R. Bendayan,et al. Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations. , 2001, Pharmacological reviews.
[89] W. Löscher,et al. P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain , 2001, Neuroreport.
[90] W. Löscher,et al. In Vivo Evidence for P‐Glycoprotein–Mediated Transport of Phenytoin at the Blood–Brain Barrier of Rats , 2001, Epilepsia.
[91] M. Pirmohamed,et al. Carbamazepine is not a substrate for P-glycoprotein. , 2001, British journal of clinical pharmacology.
[92] J. Hochman,et al. In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. , 2001, The Journal of pharmacology and experimental therapeutics.
[93] M. Thom,et al. Multidrug-resistance protein 1 in focal cortical dysplasia , 2001, The Lancet.
[94] S. Aiken,et al. Treatment of epilepsy: existing therapies and future developments. , 2000, Frontiers in bioscience : a journal and virtual library.
[95] Patrick Kwan,et al. Epilepsy after the first drug fails: substitution or add-on? , 2000, Seizure.
[96] S. Sisodiya,et al. Over-expression of P-glycoprotein in malformations of cortical development. , 1999, Neuroreport.
[97] A. Rabinowicz,et al. Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. , 1999, Pediatric neurology.
[98] Josemir W Sander,et al. Classification of the Epilepsies: Time for a Change? , 1999, European Neurology.
[99] G. Regesta,et al. Clinical aspects and biological bases of drug-resistant epilepsies , 1999, Epilepsy Research.
[100] D. Roden,et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. , 1998, The Journal of clinical investigation.
[101] R. Béliveau,et al. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. , 1997, The Biochemical journal.
[102] K. Ueda,et al. How does P-glycoprotein recognize its substrates? , 1997, Seminars in cancer biology.
[103] A. Schinkel,et al. The physiological function of drug-transporting P-glycoproteins. , 1997, Seminars in cancer biology.
[104] P. Borst. Introduction: multidrug resistant proteins , 1997 .
[105] U. Bickel,et al. Brain Microvascular and Astrocyte Localization of P‐Glycoprotein , 1997, Journal of neurochemistry.
[106] A. Schinkel,et al. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. , 1996, The Journal of clinical investigation.
[107] I. Roninson,et al. Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. , 1995, Biochemistry.
[108] N. Barbaro,et al. MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy , 1995, Epilepsia.
[109] J. H. Beijnen,et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs , 1994, Cell.
[110] W. Hauser,et al. Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984 , 1993, Epilepsia.
[111] M. Melamed,et al. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[112] S. Shorvon. Epidemiology, classification, natural history, and genetics of epilepsy , 1990, The Lancet.
[113] P Delorme,et al. An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro , 1990, Journal of neurochemistry.
[114] I. Pastan,et al. The multidrug transporter, a double-edged sword. , 1988, The Journal of biological chemistry.
[115] T. Tsuruo,et al. Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. , 1988, Cancer research.
[116] I. Roninson,et al. Localization of the human multiple drug resistance gene, MDR1, to 7q21.1 , 1987, Human Genetics.
[117] D. Housman,et al. Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins , 1986, Cell.
[118] Michael M. Gottesman,et al. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells , 1986, Cell.
[119] R L Juliano,et al. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. , 1976, Biochimica et biophysica acta.
[120] W. Pardridge,et al. Blood-brain barrier delivery. , 2007, Drug discovery today.
[121] S. Jóźwiak. [Contemporary opinions on classification, pathogenesis and treatment of drug-resistant epilepsy]. , 2007, Wiadomosci lekarskie.
[122] M. Hennessy,et al. A primer on the mechanics of P-glycoprotein the multidrug transporter. , 2007, Pharmacological research.
[123] Thomas J. Raub,et al. P-glycoprotein recognition of substrates and circumvention through rational drug design. , 2006, Molecular pharmaceutics.
[124] W. Hait,et al. Pharmacologic circumvention of multidrug resistance , 2004, Cytotechnology.
[125] M Thom,et al. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. , 2002, Brain : a journal of neurology.
[126] C. Avendaño,et al. Inhibitors of multidrug resistance to antitumor agents (MDR). , 2002, Current medicinal chemistry.
[127] B. McEwen,et al. Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications. , 2001, Annual review of pharmacology and toxicology.
[128] A. Ghose,et al. A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. , 1999, Journal of combinatorial chemistry.
[129] J. Silverman. Multidrug-resistance transporters. , 1999, Pharmaceutical biotechnology.
[130] A. Seelig. A general pattern for substrate recognition by P-glycoprotein. , 1998, European journal of biochemistry.
[131] W. Hait,et al. P-glycoprotein-mediated multidrug resistance: experimental and clinical strategies for its reversal. , 1996, Cancer treatment and research.
[132] M. Melamed,et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[133] I. Pastan,et al. Expression of a multidrug-resistance gene in human tumors and tissues. , 1987, Proceedings of the National Academy of Sciences of the United States of America.